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High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma

  • Authors:
    • Yushu Ruan
    • Fanjun Zeng
    • Zhiqiang Cheng
    • Xianda Zhao
    • Pin Fu
    • Honglei Chen
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, First College of Clinical Medical Sciences, China Three Gorges University, Yichang, Hubei 443003, P.R. China, Department of Pathology, Shenzhen People's Hospital, Shenzhen, Guangdong 518020, P.R. China, Department of Pathology, School of Basic Medical Science, Wuhan University, Wuhan, Hubei 430071, P.R. China
    Copyright: © Ruan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5727-5734
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    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6964
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Abstract

Monocarboxylate transporter 4 (MCT‑4) serves a key function in transporting lactate across the plasma membrane in various types of human cancer. Evidence indicates that MCT‑4 expression is associated with non‑small cell lung cancer; however, the distribution and clinical significance of MCT‑4 in the lung adenocarcinoma (AC) subtype remain unknown. Thus, the aim of the present study was to explore the clinicopathological significance and prognostic values of MCT‑4 expression in lung AC. Quantum dots‑based immunofluorescence histochemistry was performed to observe the expression of MCT‑4 in 146 specimens of lung AC and corresponding normal lung tissues. MCT‑4 protein and mRNA were detected by western blotting and reverse transcription‑quantitative polymerase chain reaction from 30 fresh samples of lung AC and corresponding normal lung tissues. Of the 146 samples, 25 (17.1%) exhibited high and 121 (82.9%) exhibited low MCT‑4 expression. MCT‑4, at the protein and mRNA level, was significantly increased in tumor specimens compared with corresponding normal lung tissue (P<0.05). MCT‑4 protein expression was significantly associated with depth of invasion (P=0.034). A survival curve analysis indicated that high MCT‑4 expression in lung AC was associated with a decreased overall survival rate (P=0.001). Multivariate analysis demonstrated that high MCT‑4 level was an independent prognostic factor (hazard ratio, 3.192; 95% confidence interval, 1.804‑5.646; P=0.001) for patients with lung AC. The results have demonstrated that high MCT‑4 expression is significantly associated with the poor prognosis and disease progression of patients with lung AC. Therefore, MCT‑4 may be a candidate therapeutic target in lung AC.
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Copy and paste a formatted citation
Spandidos Publications style
Ruan Y, Zeng F, Cheng Z, Zhao X, Fu P and Chen H: High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma. Oncol Lett 14: 5727-5734, 2017.
APA
Ruan, Y., Zeng, F., Cheng, Z., Zhao, X., Fu, P., & Chen, H. (2017). High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma. Oncology Letters, 14, 5727-5734. https://doi.org/10.3892/ol.2017.6964
MLA
Ruan, Y., Zeng, F., Cheng, Z., Zhao, X., Fu, P., Chen, H."High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma". Oncology Letters 14.5 (2017): 5727-5734.
Chicago
Ruan, Y., Zeng, F., Cheng, Z., Zhao, X., Fu, P., Chen, H."High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma". Oncology Letters 14, no. 5 (2017): 5727-5734. https://doi.org/10.3892/ol.2017.6964
Copy and paste a formatted citation
x
Spandidos Publications style
Ruan Y, Zeng F, Cheng Z, Zhao X, Fu P and Chen H: High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma. Oncol Lett 14: 5727-5734, 2017.
APA
Ruan, Y., Zeng, F., Cheng, Z., Zhao, X., Fu, P., & Chen, H. (2017). High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma. Oncology Letters, 14, 5727-5734. https://doi.org/10.3892/ol.2017.6964
MLA
Ruan, Y., Zeng, F., Cheng, Z., Zhao, X., Fu, P., Chen, H."High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma". Oncology Letters 14.5 (2017): 5727-5734.
Chicago
Ruan, Y., Zeng, F., Cheng, Z., Zhao, X., Fu, P., Chen, H."High expression of monocarboxylate transporter 4 predicts poor prognosis in patients with lung adenocarcinoma". Oncology Letters 14, no. 5 (2017): 5727-5734. https://doi.org/10.3892/ol.2017.6964
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