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Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance

  • Authors:
    • Lihua Xu
    • Huo Tan
    • Ruiming Liu
    • Qungai Huang
    • Nana Zhang
    • Xi Li
    • Jiani Wang
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510230, P.R. China, First Affiliated Hospital of Sun Yat‑sen University, Laboratory of Department of Surgery, Guangzhou, Guangdong 510030, P.R. China, Breast Cancer Center, The Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China, Department of Pathology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 6024-6030
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    Published online on: September 15, 2017
       https://doi.org/10.3892/ol.2017.6974
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Abstract

The cytoskeleton regulatory protein Mena is reportedly overexpressed in breast cancer; however, data regarding its expression level and clinical significance in gastric carcinoma (GC) is limited. The aim of the present study was to investigate Mena expression levels and prognostic significance in GC. Mena mRNA expression level was determined by reverse transcription‑quantitative polymerase chain reaction in 10 paired GC and adjacent normal tissues. The Mena protein expression level was analyzed in paraffin‑embedded GC samples and adjacent normal tissues by immunohistochemistry. Statistical analyses were also performed to evaluate the clinicopathological significance of Mena. The results revealed that the mRNA expression level of Mena was significantly higher in G Ct issues compared with in adjacent normal tissues from10 paired samples. In the paraffin‑embedded tissue samples, the protein expression level of Mena was higher in G Ct issues compared with in adjacent normal tissues. Compared with adjacent normal tissues, Mena overexpression was observed in 52.83% (56/106) of patients. The overexpression of Mena was significantly associated with the T stage (P=0.033), tumor‑node‑metastasis (TNM) stage (P<0.001) and decreased overall survival (P<0.001). Based on a multivariate analysis, Mena expression level was an independent prognostic factor for overall survival time. In conclusion, Mena wasoverexpressed in G C tissues and significantly associated with the T stage, TNM stage and overall survival time. Mena may therefore be suitable as a prognostic indicator for patients with GC.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Kim BS, Cho SW, Min SK and Lee BH: Differences in prognostic factors between early and advanced gastric cancer. Hepatogastroenterology. 58:1032–1040. 2011.PubMed/NCBI

3 

Saragoni L: Upgrading the definition of early gastric cancer: Better staging means more appropriate treatment. Cancer Biol Med. 12:355–361. 2015.PubMed/NCBI

4 

Krause M, Dent EW, Bear JE, Loureiro JJ and Gertler FB: Ena/VASP proteins: Regulators of the actin cytoskeleton and cell migration. Annu Rev Cell Dev Biol. 19:541–564. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Tang D, Zhang X, Huang S, Yuan H, Li J and Wang Y: Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking. Mol Biol Cell. 27:137–152. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Chen XJ, Squarr AJ, Stephan R, Chen B, Higgins TE, Barry DJ, Martin MC, Rosen MK, Bogdan S and Way M: Ena/VASP proteins cooperate with the WAVE complex to regulate the actin cytoskeleton. Dev Cell. 30:569–584. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Takahashi K and Suzuki K: WAVE2, N-WASP, and Mena facilitate cell invasion via phosphatidylinositol 3-kinase-dependent local accumulation of actin filaments. J Cell Biochem. 112:3421–3429. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Barzik M, Kotova TI, Higgs HN, Hazelwood L, Hanein D, Gertler FB and Schafer DA: Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. J Biol Chem. 280:28653–28662. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Wang W, Wyckoff JB, Goswami S, Wang Y, Sidani M, Segall JE and Condeelis JS: Coordinated regulation of pathways for enhanced cell motility and chemotaxis is conserved in rat and mouse mammary tumors. Cancer Res. 67:3505–3511. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Du JW, Xu KY, Fang LY and Qi XL: Clinical significance of Mena and Her-2 expression in breast cancer. Eur J Gynaecol Oncol. 33:455–458. 2012.PubMed/NCBI

11 

Hu K, Wang J, Yao Z, Liu B, Lin Y, Liu L and Xu L: Expression of cytoskeleton regulatory protein Mena in human hepatocellular carcinoma and its prognostic significance. Med Oncol. 31:9392014. View Article : Google Scholar : PubMed/NCBI

12 

Toyoda A, Kawana H, Azuhata K, Yu J, Omata A, Kishi H, Higashi M and Harigaya K: Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: Implications for its role in tumor progression. Int J Oncol. 34:53–60. 2009.PubMed/NCBI

13 

Gurzu S, Jung I, Prantner I, Chira L and Ember I: The immunohistochemical aspects of protein Mena in cervical lesions. Rom J Morphol Embryol. 50:213–216. 2009.PubMed/NCBI

14 

Pino MS, Balsamo M, Di Modugno F, Mottolese M, Alessio M, Melucci E, Milella M, McConkey DJ, Philippar U, Gertler FB, et al: Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clin Cancer Res. 14:4943–4950. 2008. View Article : Google Scholar : PubMed/NCBI

15 

Rutkowski P, Wozniak A, Debiec-Rychter M, Kąkol M, Dziewirski W, Zdzienicki M, Ptaszynski K, Jurkowska M, Limon J and Siedlecki JA: Clinical utility of the new American Joint Committee on Cancer staging system for gastrointestinal stromal tumors: Current overall survival after primary tumor resection. Cancer. 117:4916–4924. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Arocho A, Chen B, Ladanyi M and Pan Q: Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol. 15:56–61. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Hamashima C: Current issues and future perspectives of gastric cancer screening. World J Gastroenterol. 20:13767–13774. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Matsuda T, Ajiki W, Marugame T, Ioka A, Tsukuma H and Sobue T; Research Group of Population-Based Cancer Registries of Japan, : Population-based survival of cancer patients diagnosed between 1993 and 1999 in Japan: A chronological and international comparative study. Jpn J Clin Oncol. 41:40–51. 2011. View Article : Google Scholar : PubMed/NCBI

20 

He CZ, Zhang KH, Li Q, Liu XH, Hong Y and Lv NH: Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer. BMC Gastroenterol. 13:872013. View Article : Google Scholar : PubMed/NCBI

21 

Fuchs CS, Tomasek J, Yong CJ, Dumitru F, Passalacqua R, Goswami C, Safran H, dos Santos LV, Aprile G, Ferry DR, et al: Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): An international, randomised, multicentre, placebo-controlled, phase 3 trial. Lancet. 383:31–39. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Yamada Y, Boku N, Nishina T, Yamaguchi K, Denda T, Tsuji A, Hamamoto Y, Konishi K, Tsuji Y, Amagai K, et al: Impact of excision repair cross-complementing gene 1 (ERCC1) on the outcomes of patients with advanced gastric cancer: Correlative study in Japan Clinical Oncology Group Trial JCOG9912. Ann Oncol. 24:2560–2565. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Tewari M, Kumar A, Mishra RR, Kumar M and Shukla HS: HER2 expression in gastric and gastroesophageal cancer: Report from a tertiary care hospital in North India. Indian J Surg. 77 Suppl 2:S447–S451. 2015. View Article : Google Scholar

24 

Ye P, Zhang M, Fan S, Zhang T, Fu H, Su X, Gavine PR, Liu Q and Yin X: Intra-tumoral heterogeneity of HER2, FGFR2, cMET and ATM in gastric cancer: Optimizing personalized healthcare through innovative pathological and statistical analysis. PLoS One. 10:e01432072015. View Article : Google Scholar : PubMed/NCBI

25 

Zhou Y, Li Y, Zheng J, Liu K and Zhang H: Detecting of gastric cancer by Bcl-2 and Ki67. Int J Clin Exp Pathol. 8:7287–7290. 2015.PubMed/NCBI

26 

Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, et al: A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell. 15:813–828. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Kwiatkowski AV, Gertler FB and Loureiro JJ: Function and regulation of Ena/VASP proteins. Trends Cell Biol. 13:386–392. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Di Modugno F, Bronzi G, Scanlan MJ, Del Bello D, Cascioli S, Venturo I, Botti C, Nicotra MR, Mottolese M, Natali PG, et al: Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response. Int J Cancer. 109:909–918. 2004. View Article : Google Scholar : PubMed/NCBI

29 

Gertler FB, Niebuhr K, Reinhard M, Wehland J and Soriano P: Mena, a relative of VASP and drosophila enabled, is implicated in the control of microfilament dynamics. Cell. 87:227–239. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Bear JE, Loureiro JJ, Libova I, Fässler R, Wehland J and Gertler FB: Negative regulation of fibroblast motility by Ena/VASP proteins. Cell. 101:717–728. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Drees F and Gertler FB: Ena/VASP: Proteins at the tip of the nervous system. Curr Opin Neurobiol. 18:53–59. 2008. View Article : Google Scholar : PubMed/NCBI

32 

Neel NF, Barzik M, Raman D, Sobolik-Delmaire T, Sai J, Ham AJ, Mernaugh RL, Gertler FB and Richmond A: VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. J Cell Sci. 122:1882–1894. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Entenberg D, Wyckoff J, Gligorijevic B, Roussos ET, Verkhusha VV, Pollard JW and Condeelis J: Setup and use of a two-laser multiphoton microscope for multichannel intravital fluorescence imaging. Nat Protoc. 6:1500–1520. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Goswami S, Philippar U, Sun D, Patsialou A, Avraham J, Wang W, Di Modugno F, Nistico P, Gertler FB and Condeelis JS: Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis. 26:153–159. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Condeelis J, Singer RH and Segall JE: The great escape: When cancer cells hijack the genes for chemotaxis and motility. Annu Rev Cell Dev Biol. 21:695–718. 2005. View Article : Google Scholar : PubMed/NCBI

36 

Di Modugno F, Mottolese M, Di Benedetto A, Conidi A, Novelli F, Perracchio L, Venturo I, Botti C, Jager E, Santoni A, et al: The cytoskeleton regulatory protein hMena (ENAH) is overexpressed in human benign breast lesions with high risk of transformation and human epidermal growth factor receptor-2-positive/hormonal receptor-negative tumors. Clin Cancer Res. 12:1470–1478. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Gurzu S, Jung I, Prantner I, Ember I, Pávai Z and Mezei T: The expression of cytoskeleton regulatory protein Mena in colorectal lesions. Rom J Morphol Embryol. 49:345–349. 2008.PubMed/NCBI

38 

Di Modugno F, DeMonte L, Balsamo M, Bronzi G, Nicotra MR, Alessio M, Jager E, Condeelis JS, Santoni A, Natali PG and Nisticò P: Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: Epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Cancer Res. 67:2657–2665. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xu L, Tan H, Liu R, Huang Q, Zhang N, Li X and Wang J: Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance. Oncol Lett 14: 6024-6030, 2017.
APA
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., & Wang, J. (2017). Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance. Oncology Letters, 14, 6024-6030. https://doi.org/10.3892/ol.2017.6974
MLA
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., Wang, J."Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance". Oncology Letters 14.5 (2017): 6024-6030.
Chicago
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., Wang, J."Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance". Oncology Letters 14, no. 5 (2017): 6024-6030. https://doi.org/10.3892/ol.2017.6974
Copy and paste a formatted citation
x
Spandidos Publications style
Xu L, Tan H, Liu R, Huang Q, Zhang N, Li X and Wang J: Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance. Oncol Lett 14: 6024-6030, 2017.
APA
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., & Wang, J. (2017). Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance. Oncology Letters, 14, 6024-6030. https://doi.org/10.3892/ol.2017.6974
MLA
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., Wang, J."Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance". Oncology Letters 14.5 (2017): 6024-6030.
Chicago
Xu, L., Tan, H., Liu, R., Huang, Q., Zhang, N., Li, X., Wang, J."Expression of the cytoskeleton regulatory protein Mena in human gastric carcinoma and its prognostic significance". Oncology Letters 14, no. 5 (2017): 6024-6030. https://doi.org/10.3892/ol.2017.6974
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