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Article

AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma

  • Authors:
    • Guoan Zhang
    • Xia Kong
    • Meng Wang
    • Hongli Zhao
    • Sha Han
    • Ronghang Hu
    • Jian Huang
    • Wen Cui
  • View Affiliations / Copyright

    Affiliations: Cancer Pathology Research Institute, Jining Medical University, Jining, Shandong 272067, P.R. China, Department of Pharmacy, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, Department of Oncology, Shandong Jining No. 1 People's Hospital, Jining, Shandong 272011, P.R. China, Department of Gastroenterology, Shandong Control Center for Digestive Diseases, Jining, Shandong 272033, P.R. China, Life Science Experimental Center, Jining Medical University, Jining, Shandong 272067, P.R. China, Department of Thoracic Surgery, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China, Central Laboratory, Affiliated Hospital of Jining Medical University, Jining, Shandong 272029, P.R. China
  • Pages: 1900-1906
    |
    Published online on: November 20, 2017
       https://doi.org/10.3892/ol.2017.7443
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a common cancer in China and certain other parts of the world with a dismal prognosis for affected patients. AXL is a member of the TYRO3‑AXL‑MER family of receptor tyrosine kinases, and has been revealed to be an important mediator of epithelial‑mesenchymal transition (EMT) in several types of cancer. However, to the best of our knowledge, its function in EMT in ESCC cells has not yet been examined. The present study employed two independent ESCC mRNA profile datasets and revealed that AXL is associated with several EMT markers. Gene Set Enrichment Analysis indicated that EMT occurs more in ESCC with high AXL expression. Analysis on another dataset demonstrated further that increased expression of AXL in ESCC is associated with increased migratory ability. Collectively, the results of the present study provide evidence that AXL is a marker for EMT in ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang G, Kong X, Wang M, Zhao H, Han S, Hu R, Huang J and Cui W: AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma. Oncol Lett 15: 1900-1906, 2018.
APA
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R. ... Cui, W. (2018). AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma. Oncology Letters, 15, 1900-1906. https://doi.org/10.3892/ol.2017.7443
MLA
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R., Huang, J., Cui, W."AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma". Oncology Letters 15.2 (2018): 1900-1906.
Chicago
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R., Huang, J., Cui, W."AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma". Oncology Letters 15, no. 2 (2018): 1900-1906. https://doi.org/10.3892/ol.2017.7443
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang G, Kong X, Wang M, Zhao H, Han S, Hu R, Huang J and Cui W: AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma. Oncol Lett 15: 1900-1906, 2018.
APA
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R. ... Cui, W. (2018). AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma. Oncology Letters, 15, 1900-1906. https://doi.org/10.3892/ol.2017.7443
MLA
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R., Huang, J., Cui, W."AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma". Oncology Letters 15.2 (2018): 1900-1906.
Chicago
Zhang, G., Kong, X., Wang, M., Zhao, H., Han, S., Hu, R., Huang, J., Cui, W."AXL is a marker for epithelial‑mesenchymal transition in esophageal squamous cell carcinoma". Oncology Letters 15, no. 2 (2018): 1900-1906. https://doi.org/10.3892/ol.2017.7443
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