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Article Open Access

Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway

  • Authors:
    • Feng Jin
    • Guang Zhu
    • Dan Li
    • Tengyang Ni
    • Xiaojun Dai
    • Haibo Wang
    • Jun Feng
    • Yayun Qian
    • Lin Yang
    • Shiyu Guo
    • Tadashi Hisamitsu
    • Yanqing Liu
  • View Affiliations / Copyright

    Affiliations: Institute of Traditional Chinese Medicine and Western Medicine, School of Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, P.R. China, Department of Physiology, Showa University, Tokyo 142‑8555, Japan
    Copyright: © Jin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1591-1599
    |
    Published online on: November 21, 2017
       https://doi.org/10.3892/ol.2017.7459
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Abstract

Recently, Celastrus orbiculatus ethyl acetate extracts (COE) have been investigated for their anticancer effects on digestive tract tumors. However, the therapeutic effects of COE on esophageal squamous carcinoma cells (ESCC) have not been investigated. In the present study, the effects of COE on the cell cycle and apoptosis of ESCCs were assessed in vitro, and it was revealed that COE treatment triggered G0/G1 cell cycle arrest, and induced DNA damage and apoptosis in a dose‑dependent manner in ESCC. Activation of the phosphatidylinositol 3‑kinase/protein kinase‑B/mechanistic target of rapamycin (mTOR) pathway was also suppressed by COE. Additionally, the combined treatment with COE and rapamycin (an mTOR inhibitor) acted synergistically in ECA‑109 cells compared with the treatment with COE or rapamycin alone. These findings extend the understanding of the action of COE and suggest that COE has potential as a treatment option for ESCC as a single treatment or in combination.
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1 

Zhang Y: Epidemiology of esophageal cancer. World J Gastroenterol. 19:5598–5606. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Roshandel G, Majdzadeh R, Keshtkar A, Aramesh K, Sedaghat SM and Semnani S: Healthcare utilization in patients with esophageal cancer in a high risk area in northeast of Iran. Asian Pac J Cancer Prev. 12:2437–2442. 2011.PubMed/NCBI

3 

Maleki I, Shekarriz R, Nosrati A and Orang E: Simultaneous esophageal squamous cell carcinoma and adenocarcinoma: A case report. Middle East J Dig Dis. 7:257–260. 2015.PubMed/NCBI

4 

Roshandel G, Boreiri M, Sadjadi A and Malekzadeh R: A diversity of cancer incidence and mortality in West Asian populations. Ann Glob Health. 80:346–357. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Lu CL, Lang HC, Luo JC, Liu CC, Lin HC, Chang FY and Lee SD: Increasing trend of the incidence of esophageal squamous cell carcinoma, but not adenocarcinoma, in Taiwan. Cancer Causes Control. 21:269–274. 2010. View Article : Google Scholar : PubMed/NCBI

7 

He YT, Hou J, Chen ZF, Qiao CY, Song GH, Meng FS, Jin HX and Chen C: Trends in incidence of esophageal and gastric cardia cancer in high-risk areas in China. Eur J Cancer Prev. 17:71–76. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Porta C, Paglino C and Mosca A: Targeting PI3K/Akt/mTOR Signaling in Cancer. Front Oncol. 14:642014.

9 

Lee JJ, Loh K and Yap YS: PI3K/Akt/mTOR inhibitors in breast cancer. Cancer Biol Med. 12:342–354. 2015.PubMed/NCBI

10 

Hu A, Sun M, Yan D and Chen K: Clinical significance of mTOR and eIF4E expression in invasive ductalcarcinoma. Tumori. 100:541–546. 2014.PubMed/NCBI

11 

Liu NB, Zhang JH, Liu YF, Li J, Zhang ZZ, Li JW, Liu WY, Huang C, Shen T, Gu CW, et al: High DEPTOR expression correlates with poor prognosis in patients with esophageal squamous cell carcinoma. Onco Targets Ther. 8:3449–3455. 2015.PubMed/NCBI

12 

Burris HA III: Overcoming acquired resistance to anticancer therapy: Focus on the PI3K/AKT/mTOR pathway. Cancer Chemother Pharmacol. 71:829–842. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Wang M: Research progress of a Chinese herb Celastrus on antitumor effect. J Chinese Medicine. 25:1055–1057. 2010.(In Chinese).

14 

Li JJ, Yang J, Lu F, Qi YT, Liu YQ, Sun Y and Wang Q: Chemical constituents from the stems of Celastrus orbiculatus. Chin J Nat Med. 10:279–283. 2012.(In Chinese). View Article : Google Scholar

15 

Zan K, Chen X, Wang Q and Cao L: Chemical constituents in stem of Celastrus orbiculatus. Chin Tradit Herbal Drugs. 38:14552007.(In Chinese).

16 

Qian YY, Zhang H, Hou Y, Yuan L, Li GQ, Guo SY, Hisamits T and Liu YQ: Celastrus orbiculatus extract inhibits tumor angiogenesis by targeting vascular endothelial growth factor signaling pathway and shows potent antitumor activity in hepatocarcinomas in vitro and in vivo. Chin J Integr Med. 18:752–760. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Wang M, Zhang X, Xiong X, Yang Z, Sun Y, Yang Z, Hoffman RM and Liu Y: Efficacy of the Chinese traditional medicinal herb Celastrus orbiculatus Thunb on human hepatocellular carcinoma in an orthothopic fluorescent nude mouse model. Anticancer Res. 32:1–1220. 2012.PubMed/NCBI

18 

Zhang H, Qian Y, Liu Y, Li G, Cui P, Zhu Y, Ma H, Ji X, Guo S and Tadashi H: Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells. J Tradit Chin Med. 32:621–626. 2012. View Article : Google Scholar : PubMed/NCBI

19 

Qian YY and Liu YQ: Inhibition of Celastrus orbiculatus extracts on VEGF expression in hepatoma cells of mice. Chinese Herbal Med. 2:72–76. 2010.

20 

Hui MA, Yayun Q, Hua Z, Xue J, Yaodong Z, Pingfang C and Yanqing L: Celastrus orbiculatus extract could inhibit human colorectal carcinoma HT-29 cells metastasis via suppression of the mTOR signaling pathway. Life Sci J. 10:1704–1710. 2013.

21 

Li G, Liu D, Guo S, Sunagawa M, Hisamitsu T and Liu Y: Anti-invasive effects of Celastrus orbiculatus extract on interleukin-1 betaand tumour necrosis factor-alpha combination-stimulated fibroblast-likesynoviocytes. BMC Complement Altern Med. 14:622014. View Article : Google Scholar : PubMed/NCBI

22 

Zhu Y, Liu Y, Qian Y, Dai X, Yang L, Chen J, Guo S and Hisamitsu T: Antimetastatic effects of Celastrus orbiculatus on human Gastricadenocarcinoma by inhibiting epithelial-mesenchymal transition and NF-κB/snail signaling pathway. Integr Cancer Ther. 14:271–281. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Zhu YD, Liu YQ, Qian YY, Zhang H, Li GQ and Yang L: Extracts of Celastrus orbiculatus exhibit anti-proliferative and anti-invasiveeffects on human gastric adenocarcinoma cells. Chin J Integr Med. Nov 10–2014.(Epub ahead of print). View Article : Google Scholar

24 

Zhu Y, Liu Y, Qian Y, Yang L, Chen J, Guo S and Hisamitsu T: Research on the efficacy of Celastrus orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma. BMC Complement Altern Med. 14:4332014. View Article : Google Scholar : PubMed/NCBI

25 

Tao W, Luo X, Cui B, Liang D, Wang C, Duan Y, Li X, Zhou S, Zhao M and Li Y: Practice of traditional Chinese medicine for psycho-behavioral intervention improves quality of life in cancer patients: A systematic review and meta-analysis. Oncotarget. 6:39725–39739. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Xu H, Zhao X, Liu X, Xu P, Zhang K and Lin X: Antitumor effects of traditional Chinese medicine targeting the cellularapoptotic pathway. Drug Des Devel Ther. 9:2735–2744. 2015.PubMed/NCBI

27 

Zhang YS, Shen Q and Li J: Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy. Acta Pharmacol Sin. 37:295–302. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Liu Z, Ding Y, Ye N, Wild C, Chen H and Zhou J: Direct activation of bax protein for cancer therapy. Med Res Rev. 36:313–341. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Thomas S, Quinn BA, Das SK, Dash R, Emdad L, Dasgupta S, Wang XY, Dent P, Reed JC, Pellecchia M, et al: Targeting the Bcl-2 family for cancer therapy. Expert Opin Ther Targets. 17:61–75. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jin F, Zhu G, Li D, Ni T, Dai X, Wang H, Feng J, Qian Y, Yang L, Guo S, Guo S, et al: Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway. Oncol Lett 15: 1591-1599, 2018.
APA
Jin, F., Zhu, G., Li, D., Ni, T., Dai, X., Wang, H. ... Liu, Y. (2018). Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway. Oncology Letters, 15, 1591-1599. https://doi.org/10.3892/ol.2017.7459
MLA
Jin, F., Zhu, G., Li, D., Ni, T., Dai, X., Wang, H., Feng, J., Qian, Y., Yang, L., Guo, S., Hisamitsu, T., Liu, Y."Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway". Oncology Letters 15.2 (2018): 1591-1599.
Chicago
Jin, F., Zhu, G., Li, D., Ni, T., Dai, X., Wang, H., Feng, J., Qian, Y., Yang, L., Guo, S., Hisamitsu, T., Liu, Y."Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway". Oncology Letters 15, no. 2 (2018): 1591-1599. https://doi.org/10.3892/ol.2017.7459
Copy and paste a formatted citation
x
Spandidos Publications style
Jin F, Zhu G, Li D, Ni T, Dai X, Wang H, Feng J, Qian Y, Yang L, Guo S, Guo S, et al: Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway. Oncol Lett 15: 1591-1599, 2018.
APA
Jin, F., Zhu, G., Li, D., Ni, T., Dai, X., Wang, H. ... Liu, Y. (2018). Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway. Oncology Letters, 15, 1591-1599. https://doi.org/10.3892/ol.2017.7459
MLA
Jin, F., Zhu, G., Li, D., Ni, T., Dai, X., Wang, H., Feng, J., Qian, Y., Yang, L., Guo, S., Hisamitsu, T., Liu, Y."Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway". Oncology Letters 15.2 (2018): 1591-1599.
Chicago
Jin, F., Zhu, G., Li, D., Ni, T., Dai, X., Wang, H., Feng, J., Qian, Y., Yang, L., Guo, S., Hisamitsu, T., Liu, Y."Celastrus orbiculatus extracts induce cell cycle arrest and apoptosis in human esophageal squamous carcinoma ECA-109 cells in vitro via the PI3K/AKT/mTOR signaling pathway". Oncology Letters 15, no. 2 (2018): 1591-1599. https://doi.org/10.3892/ol.2017.7459
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