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Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells

  • Authors:
    • Junlan Qiu
    • Liang Tao
    • Qiang Wei
    • Pingyang Zhang
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Nanjing Drum Tower Hospital Clinical College, Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China, Nanjing Emergency Medical Center, Nanjing, Jiangsu 210003, P.R. China, Department of Cardiovascular Ultrasound, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China
    Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2147-2152
    |
    Published online on: December 8, 2017
       https://doi.org/10.3892/ol.2017.7558
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Abstract

ADP-ribosylation factor 6 (Arf6), a member of the ADP‑ribosylation factor family, is overexpressed in different types of cancer cell and promotes invasion, metastasis and drug resistance. However, the potential functions of Arf6 in gastric cancer (GC), and the molecular mechanism underlying these functions, remain to be fully elucidated. In the present study, the results demonstrated that in vitro knockdown of Arf6 decreased proliferation, colony formation, migration and invasion in SGC‑7901 cells. Arf6 knockdown also markedly decreased the activity of the extracellular signal‑regulated kinase 1/2 (ERK1/2) signaling pathway. Furthermore, knockdown of Arf6 was associated with elevated chemosensitivity of SGC‑7901 cells to 5‑fluorouracil through inactivation of the ERK1/2 signaling pathway. Taken together, these results suggest that Arf6 is involved in regulating proliferation, migration, invasion and drug resistance in GC, and may be a potential therapeutic target for the treatment of GC.
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Copy and paste a formatted citation
Spandidos Publications style
Qiu J, Tao L, Wei Q and Zhang P: Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells. Oncol Lett 15: 2147-2152, 2018.
APA
Qiu, J., Tao, L., Wei, Q., & Zhang, P. (2018). Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells. Oncology Letters, 15, 2147-2152. https://doi.org/10.3892/ol.2017.7558
MLA
Qiu, J., Tao, L., Wei, Q., Zhang, P."Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells". Oncology Letters 15.2 (2018): 2147-2152.
Chicago
Qiu, J., Tao, L., Wei, Q., Zhang, P."Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells". Oncology Letters 15, no. 2 (2018): 2147-2152. https://doi.org/10.3892/ol.2017.7558
Copy and paste a formatted citation
x
Spandidos Publications style
Qiu J, Tao L, Wei Q and Zhang P: Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells. Oncol Lett 15: 2147-2152, 2018.
APA
Qiu, J., Tao, L., Wei, Q., & Zhang, P. (2018). Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells. Oncology Letters, 15, 2147-2152. https://doi.org/10.3892/ol.2017.7558
MLA
Qiu, J., Tao, L., Wei, Q., Zhang, P."Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells". Oncology Letters 15.2 (2018): 2147-2152.
Chicago
Qiu, J., Tao, L., Wei, Q., Zhang, P."Knockdown of Arf6 increases drug sensitivity and inhibits proliferation, migration and invasion in gastric cancer SGC‑7901 cells". Oncology Letters 15, no. 2 (2018): 2147-2152. https://doi.org/10.3892/ol.2017.7558
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