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February-2018 Volume 15 Issue 2

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Review

Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)

  • Authors:
    • Zhong‑Tian Bai
    • Bing Bai
    • Jun Zhu
    • Cui‑Xia Di
    • Xun Li
    • Wen‑Ce Zhou
  • View Affiliations / Copyright

    Affiliations: The Second Department of General Surgery, Key Laboratory of Biotherapy and Regenerative Medicine, First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Pathology Department of Donggang Branch Courts, First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, Gansu 730000, P.R. China
  • Pages: 2049-2056
    |
    Published online on: December 13, 2017
       https://doi.org/10.3892/ol.2017.7597
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Abstract

Carcinogenesis is known to be primarily associa­ted with gene mutations. Recently, increasing evidence has suggested that epigenetic events also serve crucial roles in tumor etiology. Environmental factors, including nutrition, toxicants and ethanol, are involved in carcinogenesis through inducing epigenetic modifications, such as DNA methylation, histone deacetylase and miRNA regulation. Studying epigenetic mechanisms has facilitated the development of early diagnostic strategies and potential therapeutic avenues. Modulation at the epigenetic level, including reversing epigenetic modifications using targeted drugs, has demonstrated promise in cancer therapy. Therefore, identifying novel epigenetic biomarkers and therapeutic targets has potential for the future of cancer therapy. The present review discusses the environmental factors involved in epigenetic modifications and potential drug candidates for cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Bai ZT, Bai B, Zhu J, Di CX, Li X and Zhou WC: Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review). Oncol Lett 15: 2049-2056, 2018.
APA
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., & Zhou, W. (2018). Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review). Oncology Letters, 15, 2049-2056. https://doi.org/10.3892/ol.2017.7597
MLA
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., Zhou, W."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)". Oncology Letters 15.2 (2018): 2049-2056.
Chicago
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., Zhou, W."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)". Oncology Letters 15, no. 2 (2018): 2049-2056. https://doi.org/10.3892/ol.2017.7597
Copy and paste a formatted citation
x
Spandidos Publications style
Bai ZT, Bai B, Zhu J, Di CX, Li X and Zhou WC: Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review). Oncol Lett 15: 2049-2056, 2018.
APA
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., & Zhou, W. (2018). Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review). Oncology Letters, 15, 2049-2056. https://doi.org/10.3892/ol.2017.7597
MLA
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., Zhou, W."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)". Oncology Letters 15.2 (2018): 2049-2056.
Chicago
Bai, Z., Bai, B., Zhu, J., Di, C., Li, X., Zhou, W."Epigenetic actions of environmental factors and promising drugs for cancer therapy (Review)". Oncology Letters 15, no. 2 (2018): 2049-2056. https://doi.org/10.3892/ol.2017.7597
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