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Article Open Access

Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis

Corrigendum in: /10.3892/ol.2024.14403
  • Authors:
    • Man‑Li Li
    • You‑Zhi Xu
    • Wen‑Jie Lu
    • Yong‑Huai Li
    • Shi‑Sheng Tan
    • Hong‑Jun Lin
    • Tian‑Ming Wu
    • Yan Li
    • Si‑Ying Wang
    • Ying‑Lan Zhao
  • View Affiliations / Copyright

    Affiliations: Cancer Center, West China Hospital, West China Medical School, Sichuan University and Collaborative Innovation Center, Chengdu, Sichuan 610041, P.R. China, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Respiratory Disease, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China, Department of Oncology, Guizhou People's Hospital, Guiyang, Guizhou 510002, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2839-2846
    |
    Published online on: December 19, 2017
       https://doi.org/10.3892/ol.2017.7635
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Abstract

Sunitinib based adjuvant chemotherapy combined with chloroquine (CQ) for the treatment of renal cell carcinoma (RCC) is in clinical trials; however, its anti‑RCC effect and the mechanism remain unclear. In the present study, the anti‑RCC effect of sunitinib with CQ and the underlying mechanism was investigated. An MTT assay demonstrated that CQ enhanced the proliferation inhibitory effect of sunitinib against the OS‑RC‑2 RCC cell line. CQ inhibited sunitinib‑induced autophagy in OS‑RC‑2, which was evidenced by the inhibition of autophagic vacuoles, acidic vesicular organelle formation, light chain 3 (LC3)‑II recruitment to the autophagosomes and the conversion of LC3‑I to LC3‑II, as induced by sunitinib. The inhibition of autophagy by CQ enhanced sunitinib‑induced apoptosis, which was characterized by the activation of caspase‑3, caspase‑9, Bcl‑2 and p53. Additionally, the exposure of OS‑RC‑2 cells to CQ and sunitinib resulted in the inhibition of AKT, tuberous sclerosis complex 2, mechanistic target of rapamycin and p70 ribosomal S6 kinase, which are associated with cell proliferation. In in vivo study, a combination of sunitinib with CQ in mice significantly reduced OS‑RC‑2 cell xenograft growth compared with the sunitinib alone group. In conclusion, the present study demonstrated that CQ may enhance the anti‑RCC effect of sunitinib by inhibiting the autophagy induced by sunitinib, and enhance the rate of apoptosis. Inhibiting cell proliferation may also serve a role in the synergistic antitumor effect of sunitinib and CQ. These data suggest that combination therapy of sunitinib with CQ may be a promising strategy for adjuvant chemotherapy in RCC.
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1 

Chow WH, Dong LM and Devesa SS: Epidemiology and risk factors for kidney cancer. Nat Rev Urol. 7:245–257. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Xu K, Ding Q, Fang Z, Zheng J, Gao P, Lu Y and Zhang Y: Silencing of HIF-1alpha suppresses tumorigenicity of renal cell carcinoma through induction of apoptosis. Cancer Gene Ther. 17:212–222. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Zhao Y, Xue T, Yang X, Zhu H, Ding X, Lou L, Lu W, Yang B and He Q: Autophagy plays an important role in sunitinib-mediated cell death in H9c2 cardiac muscle cells. Toxicol App Pharmacol. 248:20–27. 2010. View Article : Google Scholar

4 

Motzer RJ, Rini BI, Bukowski RM, Curti BD, George DJ, Hudes GR, Redman BG, Margolin KA, Merchan JR, Wilding G, et al: Sunitinib in patients with metastatic renal cell carcinoma. JAMA. 295:2516–2524. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Chairatvit K and Ngamkitidechakul C: Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma. Mol Cell Biochem. 306:163–169. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Bello CL, Sherman L, Zhou J, Verkh L, Smeraglia J, Mount J and Klamerus KJ: Effect of food on the pharmacokinetics of sunitinib malate (SU11248), a multi-targeted receptor tyrosine kinase inhibitor: Results from a phase I study in healthy subjects. Anticancer Drugs. 17:353–358. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Sasaki K, Tsuno NH, Sunami E, Tsurita G, Kawai K, Okaji Y, Nishikawa T, Shuno Y, Hongo K, Hiyoshi M, et al: Chloroquine potentiates the anti-cancer effect of 5-fluorouracil on colon cancer cells. BMC Cancer. 10:3702010. View Article : Google Scholar : PubMed/NCBI

8 

Solomon VR and Lee H: Chloroquine and its analogs: A new promise of an old drug for effective and safe cancer therapies. Euro J Pharmacol. 625:220–233. 2009. View Article : Google Scholar

9 

Flanigan RC, Campbell SC, Clark JI and Picken MM: Metastatic renal cell carcinoma. Curr Trea Option Oncol. 4:385–390. 2003. View Article : Google Scholar

10 

Meijer AJ and Codogno P: Regulation and role of autophagy in mammalian cells. Int J Biochem Cell Biol. 36:2445–2462. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Ng G and Huang J: The significance of autophagy in cancer. Mol Carcinogen. 43:183–187. 2005. View Article : Google Scholar

12 

Notte A, Leclere L and Michiels C: Autophagy as a mediator of chemotherapy-induced cell death in cancer. Biochem Pharmacol. 82:427–434. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Carew JS, Nawrocki ST and Cleveland JL: Modulating autophagy for therapeutic benefit. Autophagy. 3:464–467. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Xu Y, Lu W, Yang P, Peng W, Wang C, Li M, Li Y, Li G, Meng N, Lin H, et al: A small molecular agent YL529 inhibits VEGF-D-induced lymphangiogenesis and metastasis in preclinical tumor models in addition to its known antitumor activities. BMC Cancer. 15:5252015. View Article : Google Scholar : PubMed/NCBI

15 

Asoro MA, Kovar D and Ferreira PJ: In situ transmission electron microscopy observations of sublimation in silver nanoparticles. ACS Nano. 9:7844–7852. 2013. View Article : Google Scholar

16 

Nanus DM, Garino A, Milowsky MI, Larkin M and Dutcher JP: Active chemotherapy for sarcomatoid and rapidly progressing renal cell carcinoma. Cancer. 101:1545–1551. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Sunkara U, Walczak JR, Summerson L, Rogers T, Eisenberger M, Denmeade S, Pili R, Huff CA, Sinibaldi V and Carducci MA: A phase II trial of temozolomide and IFN-alpha in patients with advanced renal cell carcinoma. J Interf Cytok Res. 24:37–41. 2004. View Article : Google Scholar

18 

Czarnecka AM, Szczylik C and Rini B: The use of sunitinib in renal cell carcinoma: Where are we now? Expert Rev Anticancer Ther. 14:983–999. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 27:3584–3590. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Milano V, Piao Y, LaFortune T and de Groot J: Dasatinib-induced autophagy is enhanced in combination with temozolomide in glioma. Mol Cancer ther. 8:394–406. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Li J, Hou N, Faried A, Tsutsumi S and Kuwano H: Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Euro J Cancer. 46:1900–1909. 2010. View Article : Google Scholar

22 

Sui X, Chen R, Wang Z, Huang Z, Kong N, Zhang M, Han W, Lou F, Yang J, Zhang Q, et al: Autophagy and chemotherapy resistance: A promising therapeutic target for cancer treatment. Cell Death Dis. 4:e8382013. View Article : Google Scholar : PubMed/NCBI

23 

Levy JM and Thorburn A: Targeting autophagy during cancer therapy to improve clinical outcomes. Pharmacol Ther. 131:130–141. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Liu J, Fan L, Wang H and Sun G: Autophagy, a double-edged sword in anti-angiogenesis therapy. Med Oncol. 33:102016. View Article : Google Scholar : PubMed/NCBI

25 

Bhutia SK, Dash R, Das SK, Azab B, Su ZZ, Lee SG, Grant S, Yacoub A, Dent P, Curiel DT, et al: Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24. Cancer Res. 70:3667–3676. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Park EJ, Kim SY, Kim SH, Lee CR, Kim IS, Park JK, Lee SW, Kim BJ, Chun JN and Jeon JH: SK&F 96365 induces apoptosis and autophagy by inhibiting Akt-mTOR signaling in A7r5 cells. Biochim Biophys Acta. 1813:2157–2164. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li ML, Xu YZ, Lu WJ, Li YH, Tan SS, Lin HJ, Wu TM, Li Y, Wang SY, Zhao YL, Zhao YL, et al: Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403. Oncol Lett 15: 2839-2846, 2018.
APA
Li, M., Xu, Y., Lu, W., Li, Y., Tan, S., Lin, H. ... Zhao, Y. (2018). Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403. Oncology Letters, 15, 2839-2846. https://doi.org/10.3892/ol.2017.7635
MLA
Li, M., Xu, Y., Lu, W., Li, Y., Tan, S., Lin, H., Wu, T., Li, Y., Wang, S., Zhao, Y."Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403". Oncology Letters 15.3 (2018): 2839-2846.
Chicago
Li, M., Xu, Y., Lu, W., Li, Y., Tan, S., Lin, H., Wu, T., Li, Y., Wang, S., Zhao, Y."Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403". Oncology Letters 15, no. 3 (2018): 2839-2846. https://doi.org/10.3892/ol.2017.7635
Copy and paste a formatted citation
x
Spandidos Publications style
Li ML, Xu YZ, Lu WJ, Li YH, Tan SS, Lin HJ, Wu TM, Li Y, Wang SY, Zhao YL, Zhao YL, et al: Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403. Oncol Lett 15: 2839-2846, 2018.
APA
Li, M., Xu, Y., Lu, W., Li, Y., Tan, S., Lin, H. ... Zhao, Y. (2018). Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403. Oncology Letters, 15, 2839-2846. https://doi.org/10.3892/ol.2017.7635
MLA
Li, M., Xu, Y., Lu, W., Li, Y., Tan, S., Lin, H., Wu, T., Li, Y., Wang, S., Zhao, Y."Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403". Oncology Letters 15.3 (2018): 2839-2846.
Chicago
Li, M., Xu, Y., Lu, W., Li, Y., Tan, S., Lin, H., Wu, T., Li, Y., Wang, S., Zhao, Y."Chloroquine potentiates the anticancer effect of sunitinib on renal cell carcinoma by inhibiting autophagy and inducing apoptosis Corrigendum in /10.3892/ol.2024.14403". Oncology Letters 15, no. 3 (2018): 2839-2846. https://doi.org/10.3892/ol.2017.7635
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