|
1
|
Global Burden of Disease Cancer
Collaboration, ; Fitzmaurice C, Dicker D, Pain A, Hamavid H,
Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, et
al: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Torre LA, Bray F, Siegel RL, Ferlay J,
Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA
Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ekman S, Dreilich M, Lennartsson J,
Wallner B, Brattström D, Sundbom M and Bergqvist M: Esophageal
cancer: Current and emerging therapy modalities. Expert Rev
Anticancer Ther. 8:1433–1448. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Li LY, Jiang H, Xie YM, Liao LD, Cao HH,
Xu XE, Chen B, Zeng FM, Zhang YL, Du ZP, et al: Macrolide analog
F806 suppresses esophageal squamous cell carcinoma (ESCC) by
blocking β1 integrin activation. Oncotarget. 6:15940–15952.
2015.PubMed/NCBI
|
|
5
|
Zhao H and Gu X: Silencing of insulin-like
growth factor-1 receptor enhances the radiation sensitivity of
human esophageal squamous cell carcinoma in vitro and in vivo.
World J Surg Oncol. 12:3252014. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Miovic M and Block S: Psychiatric
disorders in advanced cancer. Cancer. 110:1665–1676. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Tsai JH, Donaher JL, Murphy DA, Chau S and
Yang J: Spatiotemporal regulation of epithelial-mesenchymal
transition is essential for squamous cell carcinoma metastasis.
Cancer Cell. 22:725–736. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Cui Y, Wang Y, Li H, Li Q, Yu Y, Xu X, Xu
B and Liu T: Asparaginyl endopeptidase promotes the invasion and
metastasis of gastric cancer through modulating
epithelial-to-mesenchymal transition and analysis of their
phosphorylation signaling pathways. Oncotarget. 7:34356–34370.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Fong Y, Shen KH, Chiang TA and Shih YW:
Acacetin inhibits TPA-induced MMP-2 and u-PA expressions of human
lung cancer cells through inactivating JNK signaling pathway and
reducing binding activities of NF-kappaB and AP-1. J Food Sci.
75:H30–H38. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Roy R, Yang J and Moses MA: Matrix
metalloproteinases as novel biomarkers and potential therapeutic
targets in human cancer. J Clin Oncol. 27:5287–5297. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Alizadeh AM, Shiri S and Farsinejad S:
Metastasis review: From bench to bedside. Tumour Biol.
35:8483–8523. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Evans JM, Donnelly LA, Emslie-Smith AM,
Alessi DR and Morris AD: Metformin and reduced risk of cancer in
diabetic patients. BMJ. 330:1304–1305. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Cai X, Hu X, Tan X, Cheng W, Wang Q, Chen
X, Guan Y, Chen C and Jing X: Metformin induced AMPK activation,
G0/G1 phase cell cycle arrest and the inhibition of growth of
esophageal squamous cell carcinomas in vitro and in vivo. PLoS One.
10:e01333492015. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Kobayashi M, Kato K, Iwama H, Fujihara S,
Nishiyama N, Mimura S, Toyota Y, Nomura T, Nomura K, Tani J, et al:
Antitumor effect of metformin in esophageal cancer: In vitro study.
Int J Oncol. 42:517–524. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Feng Y, Ke C, Tang Q, Dong H, Zheng X, Lin
W, Ke J, Huang J, Yeung SC and Zhang H: Metformin promotes
autophagy and apoptosis in esophageal squamous cell carcinoma by
downregulating Stat3 signaling. Cell Death Dis. 5:e10882014.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Wu B, Li S, Sheng L, Zhu J, Gu L, Shen H,
La D, Hambly BD, Bao S and Di W: Metformin inhibits the development
and metastasis of ovarian cancer. Oncol Rep. 28:903–908. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Rattan R, Graham RP, Maguire JL, Giri S
and Shridhar V: Metformin suppresses ovarian cancer growth and
metastasis with enhancement of cisplatin cytotoxicity in vivo.
Neoplasia. 13:483–491. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Bao B, Wang Z, Ali S, Ahmad A, Azmi AS,
Sarkar SH, Banerjee S, Kong D, Li Y, Thakur S and Sarkar FH:
Metformin inhibits cell proliferation, migration and invasion by
attenuating CSC function mediated by deregulating miRNAs in
pancreatic cancer cells. Cancer Prev Res (Phila). 5:355–364. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Cerezo M, Tichet M, Abbe P, Ohanna M,
Lehraiki A, Rouaud F, Allegra M, Giacchero D, Bahadoran P,
Bertolotto C, et al: Metformin blocks melanoma invasion and
metastasis development in AMPK/p53-dependent manner. Mol Cancer
Ther. 12:1605–1615. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Rui X, Yan XI and Zhang K: Baicalein
inhibits the migration and invasion of colorectal cancer cells via
suppression of the AKT signaling pathway. Oncol Lett. 11:685–688.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Xie K, Nian J, Zhu X, Geng X and Liu F:
Modulatory role of garlicin in migration and invasion of
intrahepatic cholangiocarcinoma via PI3K/AKT pathway. Int J Clin
Exp Pathol. 8:14028–14033. 2015.PubMed/NCBI
|
|
23
|
Yoneyama R, Aoshiba K, Furukawa K, Saito
M, Kataba H, Nakamura H and Ikeda N: Nicotine enhances hepatocyte
growth factor-mediated lung cancer cell migration by activating the
α7 nicotine acetylcholine receptor and phosphoinositide
kinase-3-dependent pathway. Oncol Lett. 11:673–677. 2016.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Li J, Song Z, Wang Y, Yin Y, Liu Y, Yuan R
and Nan X: Overexpression of SphK1 enhances cell proliferation and
invasion in triple-negative breast cancer via the PI3K/AKT
signaling pathway. Tumour Biol. 37:10587–10593. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Tantai JC, Zhang Y and Zhao H:
Heterophyllin B inhibits the adhesion and invasion of ECA-109 human
esophageal carcinoma cells by targeting PI3K/AKT/β-catenin
signaling. Mol Med Rep. 13:1097–1104. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Romashkova JA and Makarov SS: NF-kappaB is
a target of AKT in anti-apoptotic PDGF signalling. Nature.
401:86–90. 1999. View
Article : Google Scholar : PubMed/NCBI
|
|
27
|
Li Z, Yang Z, Passaniti A, Lapidus RG, Liu
X, Cullen KJ and Dan HC: A positive feedback loop involving
EGFR/Akt/mTORC1 and IKK/NF-κB regulates head and neck squamous cell
carcinoma proliferation. Oncotarget. 7:31892–31906. 2016.PubMed/NCBI
|
|
28
|
Qin LX and Tang ZY: The prognostic
molecular markers in hepatocellular carcinoma. World J
Gastroenterol. 8:385–392. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Hsieh SC, Tsai JP, Yang SF, Tang MJ and
Hsieh YH: Metformin inhibits the invasion of human hepatocellular
carcinoma cells and enhances the chemosensitivity to sorafenib
through a downregulation of the ERK/JNK-mediated NF-κB-dependent
pathway that reduces uPA and MMP-9 expression. Amino Acids.
46:2809–2822. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Peng M, Su Q, Zeng Q, Li L, Liu Z, Xue L,
Cheng Y, Huang Y, Tao T, Lv H, et al: High efficacy of intravesical
treatment of metformin on bladder cancer in preclinical model.
Oncotarget. 7:9102–9117. 2016.PubMed/NCBI
|
|
31
|
Vujic I, Sanlorenzo M, Posch C,
Esteve-Puig R, Yen AJ, Kwong A, Tsumura A, Murphy R, Rappersberger
K and Ortiz-Urda S: Metformin and trametinib have synergistic
effects on cell viability and tumor growth in NRAS mutant cancer.
Oncotarget. 6:969–978. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Liu Y, Zhang Y, Jia K, Dong Y and Ma W:
Metformin inhibits the proliferation of A431 cells by modulating
the PI3K/Akt signaling pathway. Exp Ther Med. 9:1401–1406. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Liao H, Zhou Q, Gu Y, Duan T and Feng Y:
Luteinizing hormone facilitates angiogenesis in ovarian epithelial
tumor cells and metformin inhibits the effect through the mTOR
signaling pathway. Oncol Rep. 27:1873–1878. 2012.PubMed/NCBI
|
|
34
|
Tan BK, Adya R, Chen J, Lehnert H, Sant
Cassia LJ and Randeva HS: Metformin treatment exerts antiinvasive
and antimetastatic effects in human endometrial carcinoma cells. J
Clin Endocrinol Metab. 96:808–816. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Wu D, Wu P, Zhao L, Huang L, Zhang Z, Zhao
S and Huang J: NF-κB expression and outcomes in solid tumors: A
systematic review and meta-analysis. Medicine (Baltimore).
94:e16872015. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Chen Z and Li Z, Chang Y, Ma L, Xu W, Li
M, Li J, Zhang W, Sun Q, An X and Li Z: Relationship between NF-κB,
MMP9, and MICA expression in pituitary adenomas reveals a new
mechanism of pituitary adenomas immune escape. Neurosci Lett.
597:77–83. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Maier HJ, Schmidt-Strassburger U, Huber
MA, Wiedemann EM, Beug H and Wirth T: NF-kappaB promotes
epithelial-mesenchymal transition, migration and invasion of
pancreatic carcinoma cells. Cancer Lett. 295:214–228. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Ozes ON, Mayo LD, Gustin JA, Pfeffer SR,
Pfeffer LM and Donner DB: NF-kappaB activation by tumour necrosis
factor requires the Akt serine-threonine kinase. Nature. 401:82–85.
1999. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Li J, Deng Z, Wang Z, Wang D, Zhang L, Su
Q, Lai Y, Li B, Luo Z, Chen X, et al: Zipper-interacting protein
kinase promotes epithelial-mesenchymal transition, invasion and
metastasis through AKT and NF-κB signaling and is associated with
metastasis and poor prognosis in gastric cancer patients.
Oncotarget. 6:8323–8338. 2015.PubMed/NCBI
|
|
40
|
Martano M, Corteggio A, Restucci B, De
Biase ME, Borzacchiello G and Maiolino P: Extracellular matrix
remodeling in equine sarcoid: An immunohistochemical and molecular
study. BMC Vet Res. 12:242016. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Stallings-Mann M and Radisky D: Matrix
metalloproteinase-induced malignancy in mammary epithelial cells.
Cells Tissues Organs. 185:104–110. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Kim D, Kim S, Koh H, Yoon SO, Chung AS,
Cho KS and Chung J: Akt/PKB promotes cancer cell invasion via
increased motility and metalloproteinase production. FASEB J.
15:1953–1962. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Christofori G and Semb H: The role of the
cell-adhesion molecule E-cadherin as a tumour-suppressor gene.
Trends Biochem Sci. 24:73–76. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Hazan RB, Phillips GR, Qiao RF, Norton L
and Aaronson SA: Exogenous expression of N-cadherin in breast
cancer cells induces cell migration, invasion, and metastasis. J
Cell Biol. 148:779–790. 2000. View Article : Google Scholar : PubMed/NCBI
|
