Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
March-2018 Volume 15 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination

  • Authors:
    • Takehiro Abiko
    • Takahiro Tsuchikawa
    • Kengo Miyauchi
    • Masataka Wada
    • Noriaki Kyogoku
    • Toshiaki Shichinohe
    • Yoshihiro Miyahara
    • Shinichi Kageyama
    • Hiroaki Ikeda
    • Hiroshi Shiku
    • Satoshi Hirano
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060‑8638, Japan, Department of Immuno‑Gene Therapy, Mie University Graduate School of Medicine, Tsu, Mie 514‑8507, Japan, Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852‑8521, Japan
    Copyright: © Abiko et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3703-3711
    |
    Published online on: January 10, 2018
       https://doi.org/10.3892/ol.2018.7767
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Since 2009, a cancer vaccine clinical trial was conducted with melanoma antigen gene-A4 as an immunogenic agent. The levels of IgG1, IgG2 and IgG3, which are known to be Type 1 T helper cell‑associated antibodies, and the levels of IgG4 and IgE, which are known to be Type 2 T helper cell‑associated antibodies, were measured and used as biomarkers for predicting therapeutic effect. The results of the present study indicated a strong positive correlation between IgG2 and IgG4, with a correlation coefficient of R=0.808 (P<0.0001). The survival time of patients in which IgE responses were induced was significantly shorter compared with the survival time of patients with no IgE induction. The results of the present study suggest that caution is required when antigen‑specific IgE responses are induced during cancer vaccination therapy.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Boon T, Coulie PG, Van den Eynde BJ and van der Bruggen P: Human T cell responses against melanoma. Annu Rev Immunol. 24:175–208. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Rosenberg SA: Progress in human tumour immunology and immunotherapy. Nature. 411:380–384. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Rosenberg SA, Yang JC and Restifo NP: Cancer immunotherapy: Moving beyond current vaccines. Nat Med. 10:909–915. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Oba K, Teramukai S, Kobayashi M, Matsui T, Kodera Y and Sakamoto J: Efficacy of adjuvant immunochemotherapy with polysaccharide K for patients with curative resections of gastric cancer. Cancer Immunol Immunother. 56:905–911. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Takeoka T, Nagase H, Kurose K, Ohue Y, Yamasaki M, Takiguchi S, Sato E, Isobe M, Kanazawa T, Matsumoto M, et al: NY-ESO-1 protein cancer vaccine with poly-ICLC and OK-432: Rapid and strong induction of NY-ESO-1-specific immune responses by poly-ICLC. J Immunother. 40:140–147. 2017. View Article : Google Scholar

6 

Hoon DS, Yuzuki D, Hayashida M and Morton DL: Melanoma patients immunized with melanoma cell vaccine induce antibody responses to recombinant MAGE-1 antigen. J immunol. 154:730–737. 1995.PubMed/NCBI

7 

Noguchi M, Mine T, Komatsu N, Suekane S, Moriya F, Matsuoka K, Yutani S, Shichijo S, Yamada A, Toh U, et al: Assessment of immunological biomarkers in patients with advanced cancer treated by personalized peptide vaccination. Cancer Biol Ther. 10:1266–1279. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Yoshida K, Noguchi M, Mine T, Komatsu N, Yutani S, Ueno T, Yanagimoto H, Kawano K, Itoh K and Yamada A: Characteristics of severe adverse events after peptide vaccination for advanced cancer patients: Analysis of 500 cases. Oncol Rep. 25:57–62. 2011.PubMed/NCBI

9 

Romagnani S: TH1 and TH2 in human diseases. Clin Immunol Immunopathol. 80:225–235. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Shaw DR, Khazaeli MB and LoBuglio AF: Mouse/human chimeric antibodies to a tumor-associated antigen: Biologic activity of the four human IgG subclasses. J Natl Cancer Inst. 80:1553–1559. 1988. View Article : Google Scholar : PubMed/NCBI

11 

Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET and Carbone PP: Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 5:649–655. 1982. View Article : Google Scholar : PubMed/NCBI

12 

Kyogoku N, Ikeda H, Tsuchikawa T, Abiko T, Fujiwara A, Maki T, Yamamura Y, Ichinokawa M, Tanaka K, Imai N, et al: Time-dependent transition of the immunoglobulin G subclass and immunoglobulin E response in cancer patients vaccinated with cholesteryl pullulan-melanoma antigen gene-A4 nanogel. Oncol Lett. 12:4493–4504. 2016. View Article : Google Scholar : PubMed/NCBI

13 

Hoos A, Parmiani G, Hege K, Szno M, Loibner H, Eggermont A, Urba W, Blumenstein B, Sacks N, Keilholz U, et al: A clinical development paradigm for cancer vaccine and related biologics. J Immunother. 30:1–15. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Aoki M, Ueda S, Nishikawa H, Kitano S, Hirayama M, Ikeda H, Toyoda H, Tanaka K, Kanai M, Takabayashi A, et al: Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432. Vaccine. 27:6854–6861. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Kageyama S, Kitano S, Hirayama M, Nagata Y, Imai H, Shiraishi T, Akiyoshi K, Scott AM, Murphy R, Hoffman EW, et al: HUmoral immune responses in patients vaccinated with 1–146 HER2 protein complexed with cholesteryl pullulan nanogel. Cancer Sci. 99:601–607. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Kageyama S, Wada H, Muro K, NIwa Y, Ueda S, Miyata H, Takiguchi S, Sugino SH, Miyahara Y, Ikeda H, et al: Dose-dependent effects of NY-ESO-1 protein vaccine complexed with cholesteryl pullulan (CHP-NY-ESO-1) on immune responses and survival benefits of esophageal cancer patients. J Transl Med. 11:2462013. View Article : Google Scholar : PubMed/NCBI

17 

Gu XG, Schmitt M, Hiasa A, Nagata Y, Ikeda H, Sasaki Y, Akiyoshi K, Sunamoto J, Nakamura H, Kuribayashi K and Shiku H: A novel hydrophobized polysaccharide/oncoprotein complex vaccine induces in vitro and in vivo cellular and humoral immune responses against HER2-expressing murine sarcoma. Cancer Res. 58:3385–3390. 1998.PubMed/NCBI

18 

Hsu SM, Raine L and Fanger H: The use of antiavidin antibody and avidin-biotin-peroxidase complex in immunoperoxidase technics. Am J Clin Pathol. 75:816–821. 1981. View Article : Google Scholar : PubMed/NCBI

19 

Goydos JS, Elder E, Whiteside TL, Finn OJ and Lotze MT: A phase I trial of a synthetic mucin peptide vaccine. Induction of specific immune reactivity in patients with adenocarcinoma. J syrg Res. 63:298–304. 1996. View Article : Google Scholar

20 

Miyagi Y, Imai N, Sasatomi T, Yamada A, Mine T, Katagiri K, Nakagawa M, Muto A, Okouchi S, Isomoto H, et al: Induction of cellular immune responses to tumor cells and peptides in colorectal cancer patients by vaccination with SART3 peptides. Clin Cancer Res. 7:3950–3962. 2001.PubMed/NCBI

21 

Tsuruma T, Hata F, Torigoe T, Furuhata T, Idenoue S, Kurotaki T, Yamamoto M, Yagihashi A, Ohmura T, Yamaguchi K, et al: Phase I clinical study of anti-apoptosis protein, survivin-derived peptide vaccine therapy for patients with advanced or recurrent colorectal cancer. J Transl Med. 2:192004. View Article : Google Scholar : PubMed/NCBI

22 

Wolchok JD, Hoos A, O'Day S, Weber JS, Hamid O, Lebbé C, Maio M, Binder M, Bohnsack O, Nichol G, et al: Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria. Clin Cancer Res. 15:7412–7420. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Janetzki S, Britten CM, Kalos M, Levitsky HI, Maecker HT, Melief CJ, Old LJ, Romero P, Hoos A and Davis MM: ‘MIATA’-minimal information about T cell assays. Immunity. 31:527–528. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Kidd P: Th1/Th2 balance: The hypothesis, its limitations, and implications for health and disease. Altern Med Rev. 8:223–246. 2003.PubMed/NCBI

25 

Turner MC, Chen Y, Krewski D, Ghadirian P, Thun MJ and Calle EE: Cancer mortality among US men and women with asthma and hay fever. Am J Epidemiol. 162:212–221. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Wang H and Diepgen TL: Is atopy a protective or a risk factor for cancer? A review of epidemiological studies. Allergy. 60:1098–1111. 2005. View Article : Google Scholar : PubMed/NCBI

27 

Turner MC, Chen Y, Krewski D and Ghadirian P: An overview of the association between allergy and cancer. Int J Cancer. 118:3124–3132. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Nagy E, Berczi I and Sehon AH: Growth inhibition of murine mammary carcinoma by monoclonal IgE antibodies specific for the mammary tumor virus. Cancer Immunol Immunother. 34:63–69. 1991. View Article : Google Scholar : PubMed/NCBI

29 

Kershaw MH, Darcy PK, Trapani JA, MacGregor D and Smyth MJ: Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth. Oncol Res. 10:133–142. 1998.PubMed/NCBI

30 

Gould HJ, Mackay GA, Karagiannis SN, O'Toole CM, Marsh PJ, Daniel BE, Coney LR, Zurawski VR Jr, Joseph M, Capron M, et al: Comparison of IgE and IgG antibody-dependent cytotoxicity in vitro and in a SCID mouse xenograft model of ovarian carcinoma. Eur J Immunol. 29:3527–3537. 1999. View Article : Google Scholar : PubMed/NCBI

31 

Reali E, Greiner JW, Corti A, Gould HJ, Bottazzoli F, Paganelli G, Schlom J and Siccardi AG: IgEs targeted on tumor cells: Therapeutic activity and potential in the design of tumor vaccines. Cancer Res. 61:5517–5522. 2001.PubMed/NCBI

32 

Riemer AB, Untersmayr E, Knittelfelder R, Duschl A, Pehamberger H, Zielinski CC, Scheiner O and Jensen-Jarolim E: Active induction of tumor-specific IgE antibodies by oral mimotope vaccination. Cancer Res. 67:3406–3411. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Jensen-Jarolim E, Achatz G, Turner MC, Karagiannis S, Legrand F, Capron M, Penichet ML, Rodríguez JA, Siccardi AG, Vangelista L, et al: AllergoOncology: The role of IgE-mediated allergy in cancer. Allergy. 63:1255–1266. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Singer J and Jensen-Jarolim E: IgE-based immunotherapy of cancer: Challenges and chances. Allergy. 69:137–149. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Josephs DH, Spicer JF, Karagiannis P, Gould HJ and Karagiannis SN: IgE immunotherapy: A novel concept with promise for the treatment of cancer. MAbs. 6:54–72. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Staff C, Magnusson CG, Hojjat-Farsangi M, Mosolits S, Liljefors M, Frodin JE, Wahrén B, Mellstedt H and Ullenhag GJ: Induction of IgM, IgA and IgE antibodies in colorectal cancer patients vaccinated with a recombinant CEA protein. J Clin Lmmunol. 32:855–865. 2012. View Article : Google Scholar

37 

Schur PH: IgG subclasses. A historical perspective. Monogr Allergy. 23:1–11. 1988.PubMed/NCBI

38 

Vidarsson G, Dekkers G and Rispens T: IgG subclasses and allotypes: From structure to effector function. Front Immunol. 5:5202014. View Article : Google Scholar : PubMed/NCBI

39 

Shamji MH, Ljørring C, Francis JN, Calderon MA, Larché M, Kimber I, Frew AJ, Ipsen H, Lund K, Würtzen PA and Durham SR: Functional rather than immunoreactive levels of IgG4 correlate closely with clinical response to grass pollen immunotherapy. Allergy. 67:217–226. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Crescioli S, Correa I, Karagiannis P, Davies AM, Sutton BJ, Nestle FO and Karagiannis SN: IgG4 characteristics nad functions in cancer immunity. Curr Allergy Asthma Rep. 16:72016. View Article : Google Scholar : PubMed/NCBI

41 

Karagiannis P, Gilbert AE, Josephs DH, Ali N, Dodev T, Saul L, Correa I, Roberts L, Beddowes E, Koers A, et al: IgG4 subclass antibodies impair antitumor immunity in melanoma. J Clin Invest. 123:1457–1474. 2013. View Article : Google Scholar : PubMed/NCBI

42 

Karagiannis P, Villanova F, Josephs DH, Correa I, Van Hemelrijck M, Hobbs C, Saul L, Egbuniwe IU, Tosi I, Ilieva KM, et al: Elevated IgG4 in patient circulation is associated with the risk of disease progression in melanoma. Oncoimmunology. 4:e10324922015. View Article : Google Scholar : PubMed/NCBI

43 

Harada K, Shimoda S, Kimura Y, Sato Y, Ikeda H, Igarashi S, Ren XS, Sato H and Nakanuma Y: Significance of immunoglobulin G4 (IgG4)-positive cells in extrahepatic cholangiocarcinoma: Molecular mechanism of IgG4 reaction in cancer tissue. Hepatology. 56:157–164. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Jäger E, Gnjatic S, Nagata Y, Stockert E, Jäger D, Karbach J, Neumann A, Rieckenberg J, Chen YT, Ritter G, et al: Induction of primary NY-ESO-1 immunity: CD8+ T lymphocyte and antibody responses in peptide-vaccinated patients with NY-ESO-1+ cancers. Proc Natl Acad Sci USA. 97:pp. 12198–12203. 2000; View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Abiko T, Tsuchikawa T, Miyauchi K, Wada M, Kyogoku N, Shichinohe T, Miyahara Y, Kageyama S, Ikeda H, Shiku H, Shiku H, et al: Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination. Oncol Lett 15: 3703-3711, 2018.
APA
Abiko, T., Tsuchikawa, T., Miyauchi, K., Wada, M., Kyogoku, N., Shichinohe, T. ... Hirano, S. (2018). Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination. Oncology Letters, 15, 3703-3711. https://doi.org/10.3892/ol.2018.7767
MLA
Abiko, T., Tsuchikawa, T., Miyauchi, K., Wada, M., Kyogoku, N., Shichinohe, T., Miyahara, Y., Kageyama, S., Ikeda, H., Shiku, H., Hirano, S."Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination". Oncology Letters 15.3 (2018): 3703-3711.
Chicago
Abiko, T., Tsuchikawa, T., Miyauchi, K., Wada, M., Kyogoku, N., Shichinohe, T., Miyahara, Y., Kageyama, S., Ikeda, H., Shiku, H., Hirano, S."Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination". Oncology Letters 15, no. 3 (2018): 3703-3711. https://doi.org/10.3892/ol.2018.7767
Copy and paste a formatted citation
x
Spandidos Publications style
Abiko T, Tsuchikawa T, Miyauchi K, Wada M, Kyogoku N, Shichinohe T, Miyahara Y, Kageyama S, Ikeda H, Shiku H, Shiku H, et al: Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination. Oncol Lett 15: 3703-3711, 2018.
APA
Abiko, T., Tsuchikawa, T., Miyauchi, K., Wada, M., Kyogoku, N., Shichinohe, T. ... Hirano, S. (2018). Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination. Oncology Letters, 15, 3703-3711. https://doi.org/10.3892/ol.2018.7767
MLA
Abiko, T., Tsuchikawa, T., Miyauchi, K., Wada, M., Kyogoku, N., Shichinohe, T., Miyahara, Y., Kageyama, S., Ikeda, H., Shiku, H., Hirano, S."Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination". Oncology Letters 15.3 (2018): 3703-3711.
Chicago
Abiko, T., Tsuchikawa, T., Miyauchi, K., Wada, M., Kyogoku, N., Shichinohe, T., Miyahara, Y., Kageyama, S., Ikeda, H., Shiku, H., Hirano, S."Serum immunoglobulin E response as a marker for unfavorable prognosis following cholesteryl pullulan-MAGE A4 vaccination". Oncology Letters 15, no. 3 (2018): 3703-3711. https://doi.org/10.3892/ol.2018.7767
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team