Open Access

Potential prognostic biomarkers identified by DNA methylation profiling analysis for patients with lung adenocarcinoma

  • Authors:
    • Liankui Han
    • Gang Xu
    • Chuan Xu
    • Bo Liu
    • Di Liu
  • View Affiliations

  • Published online on: January 12, 2018     https://doi.org/10.3892/ol.2018.7790
  • Pages: 3552-3557
  • Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Lung adenocarcinoma is frequently occurring type of lung cancer with high metastatic risk. We performed a DNA methylation profiling analysis to identify possible prognostic markers involved in lung adenocarcinoma. DNA methylation profiling data (GSE66386) were downloaded from the Gene Expression Omnibus (GEO) database. Differentially methylated genes were identified using a limma package. GO enrichment analysis was performed to identify vital functions related to differential gene methylation, and pathway analysis was performed to assess the associations between different proteins with regard to regulation of cell function and metabolism. The screening results showed a total of 112,662 differentially methylated genes in lung adenocarcinoma patients compared with those of the normal controls. These CpGs were involved in 16,705 genes. The skeletal system development (P=9.46E-27) and embryonic organ morphogenesis (P=8.67E-24) were found to be involved in lung adenocarcinoma. The cancer (P=3.64E-07), Rap1 signaling (P=9.21E-05) and calcium signaling (P=9.21E-05) pathways constituted the important pathways associated with lung adenocarcinoma. In conclusion, methylated PTPRF, HOXD3, HOXD13 and CACNA1A are potential markers and may be utilized for the diagnosis and therapy of lung adenocarcinoma.
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March-2018
Volume 15 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Han L, Xu G, Xu C, Liu B and Liu D: Potential prognostic biomarkers identified by DNA methylation profiling analysis for patients with lung adenocarcinoma. Oncol Lett 15: 3552-3557, 2018
APA
Han, L., Xu, G., Xu, C., Liu, B., & Liu, D. (2018). Potential prognostic biomarkers identified by DNA methylation profiling analysis for patients with lung adenocarcinoma. Oncology Letters, 15, 3552-3557. https://doi.org/10.3892/ol.2018.7790
MLA
Han, L., Xu, G., Xu, C., Liu, B., Liu, D."Potential prognostic biomarkers identified by DNA methylation profiling analysis for patients with lung adenocarcinoma". Oncology Letters 15.3 (2018): 3552-3557.
Chicago
Han, L., Xu, G., Xu, C., Liu, B., Liu, D."Potential prognostic biomarkers identified by DNA methylation profiling analysis for patients with lung adenocarcinoma". Oncology Letters 15, no. 3 (2018): 3552-3557. https://doi.org/10.3892/ol.2018.7790