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Article

Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness

  • Authors:
    • Xingwen Wang
    • Changshun Wu
    • Baoying Yuan
    • Dan Wang
    • Huiling Liu
    • Hong Feng
    • Shui Sun
  • View Affiliations / Copyright

    Affiliations: Cancer Center, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Bone and Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China, Department of Central Laboratory, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, Jinan, Shandong 250021, P.R. China
  • Pages: 4604-4610
    |
    Published online on: January 29, 2018
       https://doi.org/10.3892/ol.2018.7889
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Abstract

Scavenger receptor class B type I (SR‑BI), a well‑documented high‑density lipoprotein receptor, has been implicated in the development and progression of human cancer. However, little is known regarding the expression profile and clinical value of SR‑BI in gastric adenocarcinoma. In the present study immunohistochemistry analysis was performed on a well‑annotated gastric adenocarcinoma tissue microarray to investigate the association between SR‑BI expression and clinicopathological parameters or patient outcome. The results revealed that SR‑BI expression was detected in 69% of the 84 gastric adenocarcinomas. Moreover, a significant association was observed between low SR‑BI expression and poor histological grade, higher Tumor‑Node‑Metastasis T stage, higher N stage and diffuse type carcinoma. Low SR‑BI expression was also significantly associated with a shorter overall survival time in patients with gastric adenocarcinoma, although it was not an independent prognostic factor. Overall, the results of the present study demonstrated that SR‑BI was possibly involved in gastric carcinogenesis and could be used as a biomarker to predict malignancy of gastric adenocarcinoma.
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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Wu C, Yuan B, Wang D, Liu H, Feng H and Sun S: Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness. Oncol Lett 15: 4604-4610, 2018.
APA
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., & Sun, S. (2018). Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness. Oncology Letters, 15, 4604-4610. https://doi.org/10.3892/ol.2018.7889
MLA
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., Sun, S."Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness". Oncology Letters 15.4 (2018): 4604-4610.
Chicago
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., Sun, S."Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness". Oncology Letters 15, no. 4 (2018): 4604-4610. https://doi.org/10.3892/ol.2018.7889
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Wu C, Yuan B, Wang D, Liu H, Feng H and Sun S: Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness. Oncol Lett 15: 4604-4610, 2018.
APA
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., & Sun, S. (2018). Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness. Oncology Letters, 15, 4604-4610. https://doi.org/10.3892/ol.2018.7889
MLA
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., Sun, S."Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness". Oncology Letters 15.4 (2018): 4604-4610.
Chicago
Wang, X., Wu, C., Yuan, B., Wang, D., Liu, H., Feng, H., Sun, S."Low scavenger receptor class B type I expression is associated with gastric adenocarcinoma tumor aggressiveness". Oncology Letters 15, no. 4 (2018): 4604-4610. https://doi.org/10.3892/ol.2018.7889
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