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Article

Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma

  • Authors:
    • Meng Wu
    • Zhihua Zhang
    • Fangxu Ma
    • Xiulong Zhang
    • Zhilin Zhang
    • Jianhua Tang
    • Ping Chen
    • Chunyan Zhou
    • Weiping Wang
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education of China, Peking University, Beijing 100191, P.R. China, Department of Respiration, First Affiliated Hospital of Hebei North University, Zhangjiakou, Heibei 075061, P.R. China
  • Pages: 5175-5180
    |
    Published online on: January 31, 2018
       https://doi.org/10.3892/ol.2018.7912
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Abstract

TAp73 and p53 are involved in regulating tumor angiogenesis and vasohibin‑1 (VASH1) is an anti‑angiogenic factor. Whether TAp73 regulates angiogenesis positively or negatively is controversial. The status of P53 may determine the effect of TAp73 on angiogenesis. To the best of our knowledge it has not been previously reported whether TAp73, p53 and VASH1 are coexpressed in lung cancer. We profiled the association between TAp73 and p53 and VASH1 expression in lung adenocarcinoma (LAC) and investigated the function of TAp73 in regulating tumor angiogenesis. TAp73, p53 and VASH1 expression in 53 human LAC tissues and the adjacent normal tissues were evaluated using immunohistochemistry. The positive expression rates of p53, TAp73 and VASH1 were significantly higher (92.6, 97.7 and 67.4%, respectively) in LAC tissue compared with paraneoplastic lung tissue (7.4, 2.3 and 32.6%, respectively, P<0.01). Pearson's correlation coefficient showed a significant positive correlation between p53 and TAp73 (r=0.474, P<0.01) and TAp73α and VASH1 (r=0.367, P<0.01). The positive expression rate of p53 and VASH1 was almost significantly correlated (r=0.187, P=0.055). Similarly, p53 expression intensity had a significant positive correlation with TAp73α (r=0.517, P<0.01) and with VASH1 (r=0.277, P<0.01), as did TAp73α with VASH1 (r=0.351, P<0.01). TAp73, p53 (mutant) and VASH1 expression was significantly higher in LAC tissue compared with paraneoplastic lung tissue. The expression trends of the three proteins were significantly positively correlated with each other in LAC. These results suggest that TAp73 may suppress tumor angiogenesis in LAC.
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1 

He YY, Zhang CX, Yang YY, Niu FY, Zeng Z, Yan HH, Xu CR, Guan JL, Zhong WZ, Yang LL, et al: Prognostic significance of genotype and number of metastatic sites in advanced non-small-cell lung cancer. Clin Lung Cancer. 15:441–447. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Yazdani S, Miki Y, Tamaki K, Ono K, Iwabuchi E, Abe K, Suzuki T, Sato Y, Kondo T and Sasano H: Proliferation and maturation of intratumoral blood vessels in non-small cell lung cancer. Hum Pathol. 44:1586–1596. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Deyoung MP and Ellisen LW: P63 and p73 in human cancer: Defining the network. Oncogene. 26:5169–5183. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Yang A, Walker N, Bronson R, Kaghad M, Oosterwegel M, Bonnin J, Vagner C, Bonnet H, Dikkes P, Sharpe A, et al: p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumors. Nature. 404:99–103. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Marqués-Garcia F, Ferrandiz N, Fernández-Alonso R, González-Cano L, Herreros-Villanueva M, Rosa-Garrido M, Fernández-García B, Vaque JP, Marqués MM, Alonso ME, et al: p73 plays a role in erythroid differentiation through GATA1 induction. J Biol Chem. 284:21139–21156. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Vikhanskaya F, Bani MR, Borsotti P, Ghilardi C, Ceruti R, Ghisleni G, Marabese M, Giavazzi R, Broggini M and Taraboletti G: p73 overexpression increases VEGF and reduces thrombospondin-1 production: Implications for tumor angiogenesis. Oncogene. 20:7293–7300. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Guan M, Peng HX, Yu B and Lu Y: p73 Overexpression and angiogenesis in human colorectal carcinoma. Jpn J Clin Oncol. 33:215–220. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Petrova V, Mancini M, Agostini M, Knight RA, Annicchiarico-Petruzzelli M, Barlev NA, Melino G and Amelio I: TAp73 transcriptionally represses BNIP3 expression. Cell Cycle. 14:2484–2493. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Stantic M, Sakil HA, Zirath H, Fang T, Sanz G, Fernandez-Woodbridge A, Marin A, Susanto E, Mak TW, Arsenian Henriksson M and Wilhelm MT: TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity. Proc Natl Acad Sci USA. 112:pp. 220–225. 2015; View Article : Google Scholar : PubMed/NCBI

10 

Dulloo I, Phang BH, Othman R, Tan SY, Vijayaraghavan A, Goh LK, Martin-Lopez M, Marques MM, Li CW, Wang de Y, et al: Hypoxia-inducible TAp73 supports tumorigenesis by regulating the angiogenic transcriptome. Nat Cell Biol. 17:511–523. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Dulloo I, Hooi PB and Sabapathy K: Hypoxia-induced DNp73 stabilization regulates Vegf-A expression and tumor angiogenesis similar to TAp73. Cell Cycle. 14:3533–3539. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Fernandez-Alonso R, Martin-Lopez M, Gonzalez-Cano L, Garcia S, Castrillo F, Diez-Prieto I, Fernandez-Corona A, Lorenzo-Marcos ME, Li X, Claesson-Welsh L, et al: p73 is required for endothelial cell differentiation, migration and the formation of vascular networks regulating VEGF and TGFβ signaling. Cell Death Differ. 22:1287–1299. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Salimath B, Marmé D and Finkenzeller G: Expression of the vascular endothelial growth factor gene is inhibited by p73. Oncogene. 19:3470–3476. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Nigro JM, Baker SJ, Preisinger AC, Jessup JM, Hostetter R, Cleary K, Bigner SH, Davidson N, Baylin S, Devilee P, et al: Mutations in the p53 gene occur in diverse human tumour types. Nature. 342:705–708. 1989. View Article : Google Scholar : PubMed/NCBI

15 

Zietz C, Rössle M, Haa C, Sendelhofer A, Hirschmann A, Stürzl M and Löhrs U: MDM-2 oncoprotein overexpression, p53 gene mutation, and VEGF up-regulation in angiosarcomas. Am J Pathol. 153:1425–1433. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Kerbel RS: Vasohibin-1: The feedback on a new inhibitor of angiogenesis. J Clin Invest. 114:884–886. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Kern JM, Bauer K, Rychli J, Wojta J, Ritsch A, Gastl G, Gunsilius E and Untergasser G: Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation. Arterioscler Thromb Vasc Biol. 28:478–484. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Yan Y, Shen Z, Ye Y, Jiang K, Zhang H, Shen C, Mustonen H, Puolakkainen P and Wang S: A novel molecular marker of prognosis in colorectal cancer: Vasohibin-1. Med Oncol. 31:8162014. View Article : Google Scholar : PubMed/NCBI

19 

Kanomata N, Sato Y, Miyaji Y, Nagai A and Moriya T: Vasohibin-1 is a new predictor of disease-free survival in operated patients with renal cell carcinoma. J Clin Pathol. 66:613–619. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, et al: Regulation of tumor angiogenesis by EZH2. Cancer Cell. 18:185–197. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Li DJ, Zhou K, Wang SG, Shi Z and Yang Z: Recombinant adenovirus encoding vasohibin prevents tumor angiogenesis and inhibits tumor growth. Cancer Sci. 101:448–452. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Kandoth C, McLellan MD, Vandin F, Ye K, Niu B, Lu C, Xie M, Zhang Q, McMichael JF, Wyczalkowski MA, et al: Mutational landscape and significance across 12 major cancer types. Nature. 502:333–339. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Oren M and Rotter V: Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol. 2:a0011072010. View Article : Google Scholar : PubMed/NCBI

24 

Melino G, Laurenzi VD and Vousden KH: p73: Friend or foe in tumorigenesis. Nat Rev Cancer. 2:605–615. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Levrero M, Laurenzi DV, Costanzo A, Gong J, Wang JY and Melino G: The p53/p63/p73 family of transcription factors: Overlapping and distinct functions. J Cell Sci. 113:1661–1670. 2000.PubMed/NCBI

26 

Amelio I, Inoue S, Markert EK, Levine AJ, Knight RA, Mak TW and Melino G: TAp73 opposes tumor angiogenesis by promoting hypoxia-inducible factor 1α degradation. Proc Natl Acad Sci USA. 112:pp. 226–231. 2015; View Article : Google Scholar : PubMed/NCBI

27 

Yoshinaga K, Ito K, Moriya T, Nagase S, Takano T, Niikura H, Sasano H, Yaegashi N and Sato Y: Roles of intrinsic angiogenesis inhibitor, vasohibin, in cervical carcinomas. Cancer Sci. 102:446–451. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Tamaki K, Sasano H, Maruo Y, Takahashi Y, Miyashita M, Moriya T, Sato Y, Hirakawa H, Tamaki N, Watanabe M, et al: Vasohibin-1 as a potential predictor of aggressive behavior of ductal carcinoma in situ of the breast. Cancer Sci. 101:1051–1058. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Wang Q, Tian X, Zhang C and Wang Q: Upregulation of vasohibin-1 expression with angiogenesis and poor prognosis of hepatocellular carcinoma after curative surgery. Med Oncol. 29:2727–2736. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Takahashi Y, Koyanagi T, Suzuki Y, Saga Y, Kanomata N, Moriya T, Suzuki M and Sato Y: Vasohibin-2 expressed in human serous ovarian adenocarcinoma accelerates tumor growth by promoting angiogenesis. Mol Cancer Res. 10:1135–1146. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Zhang T, Yu TT, Zhang DM, Hou XM, Liu XJ, Zhao D and Shan L: Vasohibin-1 expression detected by immunohistochemistry correlates with prognosis in non-small cell lung cancer. Med Oncol. 31:9632014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wu M, Zhang Z, Ma F, Zhang X, Zhang Z, Tang J, Chen P, Zhou C and Wang W: Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma. Oncol Lett 15: 5175-5180, 2018.
APA
Wu, M., Zhang, Z., Ma, F., Zhang, X., Zhang, Z., Tang, J. ... Wang, W. (2018). Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma. Oncology Letters, 15, 5175-5180. https://doi.org/10.3892/ol.2018.7912
MLA
Wu, M., Zhang, Z., Ma, F., Zhang, X., Zhang, Z., Tang, J., Chen, P., Zhou, C., Wang, W."Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma". Oncology Letters 15.4 (2018): 5175-5180.
Chicago
Wu, M., Zhang, Z., Ma, F., Zhang, X., Zhang, Z., Tang, J., Chen, P., Zhou, C., Wang, W."Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma". Oncology Letters 15, no. 4 (2018): 5175-5180. https://doi.org/10.3892/ol.2018.7912
Copy and paste a formatted citation
x
Spandidos Publications style
Wu M, Zhang Z, Ma F, Zhang X, Zhang Z, Tang J, Chen P, Zhou C and Wang W: Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma. Oncol Lett 15: 5175-5180, 2018.
APA
Wu, M., Zhang, Z., Ma, F., Zhang, X., Zhang, Z., Tang, J. ... Wang, W. (2018). Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma. Oncology Letters, 15, 5175-5180. https://doi.org/10.3892/ol.2018.7912
MLA
Wu, M., Zhang, Z., Ma, F., Zhang, X., Zhang, Z., Tang, J., Chen, P., Zhou, C., Wang, W."Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma". Oncology Letters 15.4 (2018): 5175-5180.
Chicago
Wu, M., Zhang, Z., Ma, F., Zhang, X., Zhang, Z., Tang, J., Chen, P., Zhou, C., Wang, W."Association between TAp73, p53 and VASH1 expression in lung adenocarcinoma". Oncology Letters 15, no. 4 (2018): 5175-5180. https://doi.org/10.3892/ol.2018.7912
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