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Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior

  • Authors:
    • Xun Liu
    • Shuai Zhang
    • Qinwei Gang
    • Shikai Shen
    • Jian Zhang
    • Yu Lun
    • Dongdong Xu
    • Zhiquan Duan
    • Shijie Xin
  • View Affiliations / Copyright

    Affiliations: Department of Vascular and Thyroid Surgery, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China, Department of General Surgery, The People's Hospital of Liaoning, Shenyang, Liaoning 110016, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4937-4943
    |
    Published online on: February 2, 2018
       https://doi.org/10.3892/ol.2018.7928
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Abstract

Previous studies have revealed that fibrosis may affect the biological behavior of tumors, however associated research on papillary thyroid microcarcinoma (PTMC) is rare. The aim of the present study was to explore the association between interstitial fibrosis (IF) and the biological behavior of PTMC. In the present study, a total of 511 consecutive cases of PTMC were evaluated for the presence of IF and its association with clinical parameters and pathologic biomarkers. IF was identified in 340 of the 511 consecutive cases and it was significantly associated with the age (P=0.033), tumor diameter (P=0.017) and lymphocytic metastasis (P<0.001) of the patient. There were significantly more female in the fibrosis group than in fibrosis‑absent group (P=0.024). In the analysis of clinical biomarkers using immunohistochemistical staining, IF was significantly associated with cytokeratin 19 (P=0.008) and galectin‑3 (P=0.022). Analysis of patient outcomes indicated that IF was an independent prognostic factor of recurrence (hazard ratio = 2.181; 95% confidence interval = 1.163‑4.090; P=0.015). These findings suggest that the combined effect of a patient's age, sex and tumor size may potentially contribute to fibrotic lesions and IF was a factor contributing to poor prognosis in patients with PTMC.
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Copy and paste a formatted citation
Spandidos Publications style
Liu X, Zhang S, Gang Q, Shen S, Zhang J, Lun Y, Xu D, Duan Z and Xin S: Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior. Oncol Lett 15: 4937-4943, 2018.
APA
Liu, X., Zhang, S., Gang, Q., Shen, S., Zhang, J., Lun, Y. ... Xin, S. (2018). Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior. Oncology Letters, 15, 4937-4943. https://doi.org/10.3892/ol.2018.7928
MLA
Liu, X., Zhang, S., Gang, Q., Shen, S., Zhang, J., Lun, Y., Xu, D., Duan, Z., Xin, S."Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior". Oncology Letters 15.4 (2018): 4937-4943.
Chicago
Liu, X., Zhang, S., Gang, Q., Shen, S., Zhang, J., Lun, Y., Xu, D., Duan, Z., Xin, S."Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior". Oncology Letters 15, no. 4 (2018): 4937-4943. https://doi.org/10.3892/ol.2018.7928
Copy and paste a formatted citation
x
Spandidos Publications style
Liu X, Zhang S, Gang Q, Shen S, Zhang J, Lun Y, Xu D, Duan Z and Xin S: Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior. Oncol Lett 15: 4937-4943, 2018.
APA
Liu, X., Zhang, S., Gang, Q., Shen, S., Zhang, J., Lun, Y. ... Xin, S. (2018). Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior. Oncology Letters, 15, 4937-4943. https://doi.org/10.3892/ol.2018.7928
MLA
Liu, X., Zhang, S., Gang, Q., Shen, S., Zhang, J., Lun, Y., Xu, D., Duan, Z., Xin, S."Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior". Oncology Letters 15.4 (2018): 4937-4943.
Chicago
Liu, X., Zhang, S., Gang, Q., Shen, S., Zhang, J., Lun, Y., Xu, D., Duan, Z., Xin, S."Interstitial fibrosis in papillary thyroid microcarcinoma and its association with biological behavior". Oncology Letters 15, no. 4 (2018): 4937-4943. https://doi.org/10.3892/ol.2018.7928
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