Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2018 Volume 15 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Clinical significance and effect of Sam68 expression in gastric cancer

Retraction in: /10.3892/ol.2025.15416
  • Authors:
    • Jinzhang Xiao
    • Qiuhong Wang
    • Qichang Yang
    • Hua Wang
    • Fulin Qiang
    • Song He
    • Jin Cai
    • Lei Yang
    • Yingying Wang
  • View Affiliations / Copyright

    Affiliations: Department of Internal Oncology Medicine, Affiliated Nantong Cancer Hospital, Nantong University, Nantong, Jiangsu 226000, P.R. China, The Jiangsu Province Key Laboratory for Inflammation and Molecular Drug Target, Nantong University, Nantong, Jiangsu 226000, P.R. China
    Copyright: © Xiao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4745-4752
    |
    Published online on: February 2, 2018
       https://doi.org/10.3892/ol.2018.7930
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gastric cancer is one of the most common types of malignancy worldwide. However, the molecular mechanisms of cancer development remain unclear. Src‑associated in mitosis of 68 kDa (Sam68) is involved in cell proliferation, transformation, tumorigenesis and metastasis in several types of cancer. The present study aimed to assess the expression and function of Sam68 in human gastric cancer. Western blot analysis and immunohistochemistry indicated that Sam68 expression was increased in tumor samples and the levels were associated with the grade of malignancy. High Sam68 expression was associated with the poor prognosis of patients with gastric cancer. In vitro, following knockdown of Sam68 by transfection of gastric cancer cells with small interfering RNA, the cell viability, cell cycle progress, migration and invasion were decreased. The results of the present study revealed that Sam68 may be a novel prognostic factor for, and is associated with cell growth, migration and invasion in, gastric cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Li Y, Gao H, Wang Y and Dai C: Investigation the mechanism of the apoptosis induced by lactacystin in gastric cancer cells. Tumour Biol. 36:3465–3470. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Mimica M, Tomić M, Babić E, Karin M, Bevanda M, Alfirević D, Godler Ğ and Karan D: Gastric cancer with bone marrow invasion presenting as severe thrombocytopenia. Turk J Gastroenterol. 25 Suppl 1:S229–S230. 2014. View Article : Google Scholar

3 

Cho JM, Jang YJ, Kim JH, Park SS, Park SH and Mok YJ: Pattern, timing and survival in patients with recurrent gastric cancer. Hepatogastroenterology. 61:1148–1153. 2014.PubMed/NCBI

4 

Sobin LH, Gospodarowicz MK and Wittekind C: TNM Classification of Malignant Tumors. 7th. Wiley-Blackwell; Oxford: 2010

5 

Quintana-Portillo R, Canfrán-Duque A, Issad T, Sánchez-Margalet V and González-Yanes C: Sam68 interacts with IRS1. Biochem Pharmacol. 83:78–87. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Rajan P, Gaughan L, Dalgliesh C, El-Sherif A, Robson CN, Leung HY and Elliott DJ: The RNA-binding and adaptor protein Sam68 modulates signal-dependent splicing and transcriptional activity of the androgen receptor. J Pathol. 215:67–77. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Reddy TR, Suhasini M, Xu W, Yeh LY, Yang JP, Wu J, Artzt K and Wong-Staal F: A role for KH domain proteins (Sam68-like mammalian proteins and quaking proteins) in the post-transcriptional regulation of HIV replication. J Biol Chem. 277:5778–5784. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Pedrotti S, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Stamm S, Manley JL and Sette C: The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. EMBO J. 29:1235–1247. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Wang Q, Li M, Zhang X, Huang H, Huang J, Ke J, Ding H, Xiao J, Shan X, Liu Q, et al: Upregulation of CDK7 in gastric cancer cell promotes tumor cell proliferation and predicts poor prognosis. Exp Mol Pathol. 100:514–521. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Zhang T, Wan C, Shi W, Xu J, Fan H, Zhang S, Lin Z, Ni R and Zhang X: The RNA-binding protein Sam68 regulates tumor cell viability and hepatic carcinogenesis by inhibiting the transcriptional activity of FOXOs. J Mol Histol. 46:485–497. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Huot ME, Brown CM, Lamarche-Vane N and Richard S: An adaptor role for cytoplasmic Sam68 in modulating Src activity during cell polarization. Mol Cell Biol. 29:1933–1943. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Huot MÉ, Vogel G, Zabarauskas A, Ngo CT, Coulombe-Huntington J, Majewski J and Richard S: The Sam68 STAR RNA-binding protein regulates mTOR alternative splicing during adipogenesis. Mol Cell. 46:187–199. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Sánchez-Jiménez F and Sánchez-Margalet V: Role of Sam68 in post-transcriptional gene regulation. Int J Mol Sci. 14:23402–23419. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Stockley J, Markert E, Zhou Y, Robson CN, Elliott DJ, Lindberg J, Leung HY and Rajan P: The RNA-binding protein Sam68 regulates expression and transcription function of the androgen receptor splice variant AR-V7. Sci Rep. 5:134262015. View Article : Google Scholar : PubMed/NCBI

15 

Fu K, Sun X, Zheng W, Wier EM, Hodgson A, Tran DQ, Richard S and Wan F: Sam68 modulates the promoter specificity of NF-κB and mediates expression of CD25 in activated T cells. Nat Commun. 4:19092013. View Article : Google Scholar : PubMed/NCBI

16 

Richard S, Vogel G, Huot ME, Guo T, Muller WJ and Lukong KE: Sam68 haploinsufficiency delays onset of mammary tumorigenesis and metastasis. Oncogene. 27:548–556. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Busà R, Geremia R and Sette C: Genotoxic stress causes the accumulation of the splicing regulator Sam68 in nuclear foci of transcriptionally active chromatin. Nucleic Acids Res. 38:3005–3018. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Busà R, Paronetto MP, Farini D, Pierantozzi E, Botti F, Angelini DF, Attisani F, Vespasiani G and Sette C: The RNA-binding protein Sam68 contributes to proliferation and survival of human prostate cancer cells. Oncogene. 26:4372–4382. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Lock P, Fumagalli S, Polakis P, McCormick F and Courtneidge SA: The human p62 cDNA encodes Sam68 and not the RasGAP-associated p62 protein. Cell. 84:23–24. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Song J and Richard S: Sam68 regulates S6K1 alternative splicing during adipogenesis. Mol Cell Biol. 35:1926–1939. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Zhao X, Li Z, He B, Liu J, Li S, Zhou L, Pan C, Yu Z and Xu Z: Sam68 is a novel marker for aggressive neuroblastoma. Onco Targets Ther. 6:1751–1760. 2013.PubMed/NCBI

22 

Modem S, Badri KR, Holland TC and Reddy TR: Sam68 is absolutely required for Rev function and HIV-1 production. Nucleic Acids Res. 33:873–879. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Paronetto MP, Messina V, Barchi M, Geremia R, Richard S and Sette C: Sam68 marks the transcriptionally active stages of spermatogenesis and modulates alternative splicing in male germ cells. Nucleic Acids Res. 39:4961–4974. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Xiao J, Wang Q, Yang Q, Wang H, Qiang F, He S, Cai J, Yang L and Wang Y: Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416. Oncol Lett 15: 4745-4752, 2018.
APA
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S. ... Wang, Y. (2018). Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416. Oncology Letters, 15, 4745-4752. https://doi.org/10.3892/ol.2018.7930
MLA
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S., Cai, J., Yang, L., Wang, Y."Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416". Oncology Letters 15.4 (2018): 4745-4752.
Chicago
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S., Cai, J., Yang, L., Wang, Y."Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416". Oncology Letters 15, no. 4 (2018): 4745-4752. https://doi.org/10.3892/ol.2018.7930
Copy and paste a formatted citation
x
Spandidos Publications style
Xiao J, Wang Q, Yang Q, Wang H, Qiang F, He S, Cai J, Yang L and Wang Y: Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416. Oncol Lett 15: 4745-4752, 2018.
APA
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S. ... Wang, Y. (2018). Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416. Oncology Letters, 15, 4745-4752. https://doi.org/10.3892/ol.2018.7930
MLA
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S., Cai, J., Yang, L., Wang, Y."Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416". Oncology Letters 15.4 (2018): 4745-4752.
Chicago
Xiao, J., Wang, Q., Yang, Q., Wang, H., Qiang, F., He, S., Cai, J., Yang, L., Wang, Y."Clinical significance and effect of Sam68 expression in gastric cancer Retraction in /10.3892/ol.2025.15416". Oncology Letters 15, no. 4 (2018): 4745-4752. https://doi.org/10.3892/ol.2018.7930
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team