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Article

Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer

  • Authors:
    • Gaochen Lan
    • Jie Li
    • Qiaomei Wen
    • Lin Lin
    • Libin Chen
    • Liyu Chen
    • Xi Chen
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Fujian Tingzhou Hospital, Longyan, Fujian 366300, P.R. China, Department of Oncology, Fuzhou General Hospital of Nanjing Military Command, Fuzhou, Fujian 350025, P.R. China, Department of Traditional Chinese Medicine, Lihe Traditional Chinese Medicine Policlinic, Xiamen, Fujian 361000, P.R. China, Department of Emergency, Jinjiang Hospital of Traditional Chinese Medicine, Quanzhou, Fujian 362200, P.R. China, Department of Pathology, Affiliated Hospital of Putian College, Putian, Fujian 351100, P.R. China
  • Pages: 5093-5097
    |
    Published online on: February 7, 2018
       https://doi.org/10.3892/ol.2018.7991
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Abstract

Cytotoxic T lymphocyte associated antigen 4 (CTLA‑4) serves an important role in inhibiting anti‑tumor immune response in the majority of solid tumors. However, a limited number of studies reported the function of CTLA‑4 in luminal B HER2‑negative breast cancer. Immunohistochemistry was performed to evaluate the expression of tumor and interstitial CTLA‑4 in luminal B HER2‑negative breast cancer tissues. The percentage of patients with tumor and interstitial CTLA‑4+ was 41.2% (42/102) and 46.1% (47/102), respectively. There was a positive association between tumor CTLA‑4 expression and interstitial CTLA‑4 expression (P<0.05). The disease‑free survival (DFS) of the tumor CTLA‑4+ group was significantly shorter compared with patients with tumor CTLA‑4‑ (mean, 89.070 vs. 39.022 months; P<0.0001). Additionally, the DFS of interstitial CTLA‑4+ group was shorter compared with the interstitial CTLA‑4‑ group (mean, 85.526 vs. 46.574 months; P<0.0001). Tumor and interstitial CTLA‑4 expression may have prognostic predicting value in luminal B HER2‑negative breast cancer. The present study may provide the basis for the use of a CTLA‑4 blocker in patients with luminal B HER2‑negative breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Lan G, Li J, Wen Q, Lin L, Chen L, Chen L and Chen X: Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer. Oncol Lett 15: 5093-5097, 2018.
APA
Lan, G., Li, J., Wen, Q., Lin, L., Chen, L., Chen, L., & Chen, X. (2018). Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer. Oncology Letters, 15, 5093-5097. https://doi.org/10.3892/ol.2018.7991
MLA
Lan, G., Li, J., Wen, Q., Lin, L., Chen, L., Chen, L., Chen, X."Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer". Oncology Letters 15.4 (2018): 5093-5097.
Chicago
Lan, G., Li, J., Wen, Q., Lin, L., Chen, L., Chen, L., Chen, X."Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer". Oncology Letters 15, no. 4 (2018): 5093-5097. https://doi.org/10.3892/ol.2018.7991
Copy and paste a formatted citation
x
Spandidos Publications style
Lan G, Li J, Wen Q, Lin L, Chen L, Chen L and Chen X: Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer. Oncol Lett 15: 5093-5097, 2018.
APA
Lan, G., Li, J., Wen, Q., Lin, L., Chen, L., Chen, L., & Chen, X. (2018). Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer. Oncology Letters, 15, 5093-5097. https://doi.org/10.3892/ol.2018.7991
MLA
Lan, G., Li, J., Wen, Q., Lin, L., Chen, L., Chen, L., Chen, X."Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer". Oncology Letters 15.4 (2018): 5093-5097.
Chicago
Lan, G., Li, J., Wen, Q., Lin, L., Chen, L., Chen, L., Chen, X."Cytotoxic T lymphocyte associated antigen 4 expression predicts poor prognosis in luminal B HER2-negative breast cancer". Oncology Letters 15, no. 4 (2018): 5093-5097. https://doi.org/10.3892/ol.2018.7991
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