|
1
|
Chen W, Zheng R, Baade PD, Zhang S, Zeng
H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China,
2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2016. CA Cancer J Clin. 66:7–30. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Ito Y and Miyazono K: RUNX transcription
factors as key targets of TGF-beta superfamily signaling. Curr Opin
Genet Dev. 13:43–47. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Coffman JA: Runx transcription factors and
the developmental balance between cell proliferation and
differentiation. Cell Biol Int. 27:315–324. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Cameron ER, Blyth K, Hanlon L, Kilbey A,
Mackay N, Stewart M, Terry A, Vaillant F, Wotton S and Neil JC: The
Runx genes as dominant oncogenes. Blood Cells Mol Dis. 30:194–200.
2003. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Ito Y, Osato M and Ito K: RUNX and cancer.
Ann Acad Med Singapore. 32 5 Suppl:S6–S7. 2003.PubMed/NCBI
|
|
7
|
Levanon D, Brenner O, Otto F and Groner Y:
Runx3 knockouts and stomach cancer. EMBO Rep. 4:560–564. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Levanon D, Glusman G, Bettoun D, Ben-Asher
E, Negreanu V, Bernstein Y, Harris-Cerruti C, Brenner O, Eilam R,
Lotem J, et al: Phylogenesis and regulated expression of the RUNT
domain transcription factors RUNX1 and RUNX3. Blood Cells Mol Dis.
30:161–163. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Miyazono K, Suzuki H and Imamura T:
Regulation of TGF-beta signaling and its roles in progression of
tumors. Cancer Sci. 94:230–234. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Otto F, Stock M, Fliegauf M, Fenaux P,
Preudhomme C and Lübbert M: Absence of somatic mutations within the
Runt domain of AML2/RUNX3 in acute myeloid leukaemia. Leukemia.
17:1677–1678. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Li QL, Ito K, Sakakura C, Fukamachi H,
Inoue Ki, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, et al: Causal
relationship between the loss of RUNX3 expression and gastric
cancer. Cell. 109:113–124. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Kim R, Trubetskoy A, Suzuki T, Jenkins NA,
Copeland NG and Lenz J: Genome-based identification of cancer genes
by proviral tagging in mouse retrovirus-induced T-cell lymphomas. J
Virol. 77:2056–2062. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Yanagawa N, Tamura G, Oizumi H, Takahashi
N, Shimazaki Y and Motoyama T: Promoter hypermethylation of tumor
suppressor and tumor-related genes in non-small cell lung cancers.
Cancer Sci. 94:589–592. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Anglin I and Passaniti A: Runx protein
signaling in human cancers. Cancer Treat Res. 119:189–215. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Bae SC and Choi JK: Tumor suppressor
activity of RUNX3. Oncogene. 23:4336–4340. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Goel A, Arnold CN, Tassone P, Chang DK,
Niedzwiecki D, Dowell JM, Wasserman L, Compton C, Mayer RJ,
Bertagnolli MM and Boland CR: Epigenetic inactivation of RUNX3 in
microsatellite unstable sporadic colon cancers. Int J Cancer.
112:754–759. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Kang GH, Lee S, Lee HJ and Hwang KS:
Aberrant CpG island hypermethylation of multiple genes in prostate
cancer and prostatic intraepithelial neoplasia. J Pathol.
202:233–240. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Li QL, Kim HR, Kim WJ, Choi JK, Lee YH,
Kim HM, Li LS, Kim H, Chang J, Ito Y, et al: Transcriptional
silencing of the RUNX3 gene by CpG hypermethylation is associated
with lung cancer. Biochem Biophys Res Commun. 314:223–228. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Wada M, Yazumi S, Takaishi S, Hasegawa K,
Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y and Chiba T:
Frequent loss of RUNX3 gene expression in human bile duct and
pancreatic cancer cell lines. Oncogene. 23:2401–2407. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Tamura G: Promoter methylation status of
tumor suppressor and tumor-related genes in neoplastic and
non-neoplastic gastric epithelia. Histol Histopathol. 19:221–228.
2004.PubMed/NCBI
|
|
21
|
Oshimo Y, Oue N, Mitani Y, Nakayama H,
Kitadai Y, Yoshida K, Ito Y, Chayama K and Yasui W: Frequent loss
of RUNX3 expression by promoter hypermethylation in gastric
carcinoma. Pathobiology. 71:137–143. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Fainaru O, Woolf E, Lotem J, Yarmus M,
Brenner O, Goldenberg D, Negreanu V, Bernstein Y, Levanon D, Jung S
and Groner Y: Runx3 regulates mouse TGF-beta-mediated dendritic
cell function and its absence results in airway inflammation. EMBO
J. 23:969–979. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Ito K, Liu Q, Salto-Tellez M, Yano T, Tada
K, Ida H, Huang C, Shah N, Inoue M, Rajnakova A, et al: RUNX3, a
novel tumor suppressor, is frequently inactivated in gastric cancer
by protein mislocalization. Cancer Res. 65:7743–7750. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Lau QC, Raja E, Salto-Tellez M, Liu Q, Ito
K, Inoue M, Putti TC, Loh M, Ko TK, Huang C, et al: RUNX3 is
frequently inactivated by dual mechanisms of protein
mislocalization and promoter hypermethylation in breast cancer.
Cancer Res. 66:6512–6520. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Soong R, Shah N, Peh BK, Chong PY, Ng SS,
Zeps N, Joseph D, Salto-Tellez M, Iacopetta B and Ito Y: The
expression of RUNX3 in colorectal cancer is associated with disease
stage and patient outcome. Br J Cancer. 100:676–679. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Mello RB, Silva MR, Alves MT, Evison MP,
Guimarães MA, Francisco RA, Astolphi RD and Iwamura ES: Tissue
microarray analysis applied to bone diagenesis. Sci Rep.
7:399872017. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Eskaros AR, Egloff SA, Boyd KL, Richardson
JE, Hyndman ME and Zijlstra A: Larger core size has superior
technical and analytical accuracy in bladder tissue microarray. Lab
Invest. 97:335–342. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Chen X, Song N, Matsumoto K, Nanashima A,
Nagayasu T, Hayashi T, Ying M, Endo D, Wu Z and Koji T: High
expression of trimethylated histone H3 at lysine 27 predicts better
prognosis in non-small cell lung cancer. Int J Oncol. 43:1467–1480.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Deng Y, Chen X, Ye Y, Shi X, Zhu K, Huang
L, Zhang S, Ying M and Lin X: Histological characterisation and
prognostic evaluation of 62 gastric neuroendocrine carcinomas.
Contemp Oncol (Pozn). 20:311–319. 2016.PubMed/NCBI
|
|
30
|
Gavrieli Y, Sherman Y and Ben-Sasson SA:
Identification of programmed cell death in situ via specific
labeling of nuclear DNA fragmentation. J Cell Biol. 119:493–501.
1992. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Song N, Liu J, An S, Nishino T, Hishikawa
Y and Koji T: Immunohistochemical analysis of histone H3
modifications in germ cells during mouse spermatogenesis. Acta
Histochem Cytochem. 44:183–190. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Camp RL, Dolled-Filhart M and Rimm DL:
X-tile: A new bio-informatics tool for biomarker assessment and
outcome-based cut-point optimization. Clin Cancer Res.
10:7252–7259. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Araki K, Osaki M, Nagahama Y, Hiramatsu T,
Nakamura H, Ohgi S and Ito H: Expression of RUNX3 protein in human
lung adenocarcinoma: Implications for tumor progression and
prognosis. Cancer Sci. 96:227–231. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zhang C, Li J, Huang T, Duan S, Dai D,
Jiang D, Sui X, Li D, Chen Y, Ding F, et al: Meta-analysis of DNA
methylation biomarkers in hepatocellular carcinoma. Oncotarget.
7:81255–81267. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Whittle MC and Hingorani SR: RUNX3 defines
disease behavior in pancreatic ductal adenocarcinoma. Mol Cell
Oncol. 3:e10765882015. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Chen F, Liu X, Bai J, Pei D and Zheng J:
The emerging role of RUNX3 in cancer metastasis (Review). Oncol
Rep. 35:1227–1236. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Kang KA, Piao MJ, Ryu YS, Maeng YH and
Hyun JW: Cytoplasmic localization of RUNX3 via histone
deacetylase-mediated SRC expression in oxidative-stressed colon
cancer cells. J Cell Physiol. 232:1914–1921. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Chen F, Bai J, Li W, Mei P, Liu H, Li L,
Pan Z, Wu Y and Zheng J: RUNX3 suppresses migration, invasion and
angiogenesis of human renal cell carcinoma. PLoS One. 8:e562412013.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Xue J, Wu XL, Huang XT, Qu M, Guo F, Sun
GY, Zhang PC, Han L and Pan LM: Correlation of RUNX3 expression
with microvessel density in colorectal adenocarcinoma tissues and
clinical significance. Asian Pac J Trop Med. 10:98–101. 2017.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Goh YM, Cinghu S, Hong ET, Lee YS, Kim JH,
Jang JW, Li YH, Chi XZ, Lee KS, Wee H, et al: Src kinase
phosphorylates RUNX3 at tyrosine residues and localizes the protein
in the cytoplasm. J Biol Chem. 285:10122–10129. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Mabuchi M, Kataoka H, Miura Y, Kim TS,
Kawaguchi M, Ebi M, Tanaka M, Mori Y, Kubota E, Mizushima T, et al:
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates
to the nucleus with runt domain transcription factor 3 (RUNX3) in
response to TGF-beta signal transduction. Biochem Biophys Res
Commun. 398:321–325. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Lee KS, Lee YS, Lee JM, Ito K, Cinghu S,
Kim JH, Jang JW, Li YH, Goh YM, Chi XZ, et al: Runx3 is required
for the differentiation of lung epithelial cells and suppression of
lung cancer. Oncogene. 29:3349–3361. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Fujii S, Ito K, Ito Y and Ochiai A:
Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by
increasing histone H3 methylation. J Biol Chem. 283:17324–17332.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Zhang H, Fillmore Brainson C, Koyama S,
Redig AJ, Chen T, Li S, Gupta M, Garcia-de-Alba C, Paschini M,
Herter-Sprie GS, et al: Lkb1 inactivation drives lung cancer
lineage switching governed by Polycomb Repressive Complex 2. Nat
Commun. 8:149222017. View Article : Google Scholar : PubMed/NCBI
|
