search button
Open Access

Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer

  • Authors:
    • Erna Guo
    • Haotang Wei
    • Xiwen Liao
    • Yang Xu
    • Shu Li
    • Xiaoyun Zeng

  • View Affiliations

  • Published online on: February 9, 2018     https://doi.org/10.3892/ol.2018.8007
  • Pages: 5505-5516

  • Copyright: © Guo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ADH genes was investigated in patients with GC using the Kaplan‑Meier plotter tool. Kaplan‑Meier plots were used to assess the difference between groups of patients with GC with different prognoses. Hazard ratios (HR) and 95% confidence intervals (CI) were used to assess the relative risk of GC survival. Overall, 593 patients with GC and 7 ADH genes were included in the survival analysis. High expression of ADH 1A (class 1), α polypeptide (ADH1A; log‑rank P=0.043; HR=0.79; 95% CI: 0.64‑0.99), ADH 1B (class 1), β polypeptide (ADH1B; log‑rank P=1.9x10‑05; HR=0.65; 95% CI: 0.53‑0.79) and ADH 5 (class III), χ polypeptide (ADH5; log‑rank P=0.0011; HR=0.73; 95% CI: 0.6‑0.88) resulted in a significantly decreased risk of mortality in all patients with GC compared with patients with low expression of those genes. Furthermore, protective effects may additionally be observed in patients with intestinal‑type GC with high expression of ADH1B (log‑rank P=0.031; HR=0.64; 95% CI: 0.43‑0.96) and patients with diffuse‑type GC with high expression of ADH1A (log‑rank P=0.014; HR=0.51; 95% CI: 0.3‑0.88), ADH1B (log‑rank P=0.04; HR=0.53; 95% CI: 0.29‑0.98), ADH 4 (class II), π polypeptide (log‑rank P=0.033; HR=0.58; 95% CI: 0.35‑0.96) and ADH 6 (class V) (log‑rank P=0.037; HR=0.59; 95% CI: 0.35‑0.97) resulting in a significantly decreased risk of mortality compared with patients with low expression of those genes. In contrast, patients with diffuse‑type GC with high expression of ADH5 (log‑rank P=0.044; HR=1.66; 95% CI: 1.01‑2.74) were significantly correlated with a poor prognosis. The results of the present study suggest that ADH1A and ADH1B may be potential prognostic biomarkers of GC, whereas the prognostic value of other ADH genes requires further investigation.
View Figures
View References

Related Articles

Journal Cover

April-2018
Volume 15 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 2.9
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 6.3
  • CiteScore Rank: Q2: #119/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.725
  • SCImago Journal Rank (SJR): 0.639
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Guo E, Wei H, Liao X, Xu Y, Li S and Zeng X: Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer. Oncol Lett 15: 5505-5516, 2018
APA
Guo, E., Wei, H., Liao, X., Xu, Y., Li, S., & Zeng, X. (2018). Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer. Oncology Letters, 15, 5505-5516. https://doi.org/10.3892/ol.2018.8007
MLA
Guo, E., Wei, H., Liao, X., Xu, Y., Li, S., Zeng, X."Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer". Oncology Letters 15.4 (2018): 5505-5516.
Chicago
Guo, E., Wei, H., Liao, X., Xu, Y., Li, S., Zeng, X."Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer". Oncology Letters 15, no. 4 (2018): 5505-5516. https://doi.org/10.3892/ol.2018.8007