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Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells

  • Authors:
    • Yuefeng Han
    • Mingjie Zhang
    • Deshang Chen
    • Hui Li
    • Xiaomin Wang
    • Shiyin Ma
  • View Affiliations / Copyright

    Affiliations: Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 5680-5684
    |
    Published online on: February 9, 2018
       https://doi.org/10.3892/ol.2018.8012
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Abstract

RNA binding motif protein 17 (RBM17) is a protein-coding gene. The protein encoded by RBM17 is involved in the regulation of alternative splicing and is overexpressed in cancer. The present study aimed to determine the effect of RBM17-knockdown in hypopharyngeal carcinoma FaDu cells using the lentivirus‑mediated shRNA method. Cell proliferation was detected by an MTT assay. Flow cytometry analysis was used to determine cell cycle distribution and apoptosis. The results of the present study demonstrated that RBM17 expression was significantly decreased in FaDu cells infected with lentivirus‑shRNA. Knockdown of RBM17 expression by shRNA significantly reduced cell proliferation, augmented cell apoptosis and arrested cells at the G2/M phase in FaDu cells. The results of the present study indicate that RBM17 serves a notable role in cell proliferation, cell cycle progression and apoptosis of hypopharyngeal carcinoma cells.
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Copy and paste a formatted citation
Spandidos Publications style
Han Y, Zhang M, Chen D, Li H, Wang X and Ma S: Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells. Oncol Lett 15: 5680-5684, 2018.
APA
Han, Y., Zhang, M., Chen, D., Li, H., Wang, X., & Ma, S. (2018). Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells. Oncology Letters, 15, 5680-5684. https://doi.org/10.3892/ol.2018.8012
MLA
Han, Y., Zhang, M., Chen, D., Li, H., Wang, X., Ma, S."Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells". Oncology Letters 15.4 (2018): 5680-5684.
Chicago
Han, Y., Zhang, M., Chen, D., Li, H., Wang, X., Ma, S."Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells". Oncology Letters 15, no. 4 (2018): 5680-5684. https://doi.org/10.3892/ol.2018.8012
Copy and paste a formatted citation
x
Spandidos Publications style
Han Y, Zhang M, Chen D, Li H, Wang X and Ma S: Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells. Oncol Lett 15: 5680-5684, 2018.
APA
Han, Y., Zhang, M., Chen, D., Li, H., Wang, X., & Ma, S. (2018). Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells. Oncology Letters, 15, 5680-5684. https://doi.org/10.3892/ol.2018.8012
MLA
Han, Y., Zhang, M., Chen, D., Li, H., Wang, X., Ma, S."Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells". Oncology Letters 15.4 (2018): 5680-5684.
Chicago
Han, Y., Zhang, M., Chen, D., Li, H., Wang, X., Ma, S."Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells". Oncology Letters 15, no. 4 (2018): 5680-5684. https://doi.org/10.3892/ol.2018.8012
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