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Article Open Access

Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo

  • Authors:
    • Xiaojie Sun
    • Manhua Cui
    • Ding Wang
    • Baofeng Guo
    • Ling Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China, Department of Gynaecology and Obstetrics, The Second Hospital of Jilin University, Changchun, Jilin 130022, P.R. China, Department of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun, Jilin 130021 P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5744-5750
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/ol.2018.8071
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Abstract

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a member of tumor necrosis factor (TNF) superfamily and functions to promote apoptosis by binding to cell surface death receptor (DR)4 and DR5. Cancer cells are more sensitive than normal cells to TRAIL‑induced apoptosis, and TRAIL‑based therapeutic strategies have shown promise for the treatment of cancer. The present study investigated whether enforced overexpression of TRAIL in cervical cancer cells promoted cell death in the presence or absence of Taxol, an important first‑line cancer chemotherapeutic drug. Hela human cervical cancer cells were transfected with a TRAIL expression plasmid, and the effects of the combination treatment with Taxol on apoptosis was investigated in vitro and in tumor xenografts in vivo. The results indicated that Taxol treatment and TRAIL overexpression enhanced apoptosis compared with either treatment alone. The present data indicate that Taxol may enhance the pro‑apoptotic effects of TRAIL overexpression in HeLa cells by increasing cleaved caspase‑3 and DR5 expression levels and decreasing Bcl‑2 expression levels. Furthermore, the findings suggest a possible novel treatment option for cervical cancer and uncovers a potential mechanism of the enhancing effects of Taxol on TRAIL‑induced apoptosis.
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Copy and paste a formatted citation
Spandidos Publications style
Sun X, Cui M, Wang D, Guo B and Zhang L: Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo. Oncol Lett 15: 5744-5750, 2018.
APA
Sun, X., Cui, M., Wang, D., Guo, B., & Zhang, L. (2018). Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo. Oncology Letters, 15, 5744-5750. https://doi.org/10.3892/ol.2018.8071
MLA
Sun, X., Cui, M., Wang, D., Guo, B., Zhang, L."Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo". Oncology Letters 15.4 (2018): 5744-5750.
Chicago
Sun, X., Cui, M., Wang, D., Guo, B., Zhang, L."Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo". Oncology Letters 15, no. 4 (2018): 5744-5750. https://doi.org/10.3892/ol.2018.8071
Copy and paste a formatted citation
x
Spandidos Publications style
Sun X, Cui M, Wang D, Guo B and Zhang L: Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo. Oncol Lett 15: 5744-5750, 2018.
APA
Sun, X., Cui, M., Wang, D., Guo, B., & Zhang, L. (2018). Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo. Oncology Letters, 15, 5744-5750. https://doi.org/10.3892/ol.2018.8071
MLA
Sun, X., Cui, M., Wang, D., Guo, B., Zhang, L."Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo". Oncology Letters 15.4 (2018): 5744-5750.
Chicago
Sun, X., Cui, M., Wang, D., Guo, B., Zhang, L."Tumor necrosis factor-related apoptosis inducing ligand overexpression and Taxol treatment suppresses the growth of cervical cancer cells in vitro and in vivo". Oncology Letters 15, no. 4 (2018): 5744-5750. https://doi.org/10.3892/ol.2018.8071
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