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Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer

  • Authors:
    • Xiaokang Li
    • Yaqing Li
    • Ying Zhu
    • Li Fu
    • Peifang Liu
  • View Affiliations / Copyright

    Affiliations: Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Tianjin 300060, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5643-5649
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/ol.2018.8078
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Abstract

The aim of the present study was to evaluate the association between enhancement patterns and parameters in contrast‑enhanced ultrasonography (CEUS) and microvessel distribution and histological prognostic tumor characteristics of breast cancer. Between September 2011 and April 2013, 109 breast lesions were prospectively analyzed, which were classified into Breast Imaging Reporting and Data System class 4‑5 by conventional ultrasound. Before core‑needle biopsy, CEUS examination was performed. Different enhan­cement patterns (homogeneous, peripheral and regional enhancement) were evaluated. Following CEUS, biopsies were performed at the same body positions under guidance of ultrasound. Parameters (wash‑in time, peak intensity, time to peak, area under the time‑intensity curve, ascending slope) of CEUS at corresponding puncture sites were recorded. Microvessel density (MVD) and pathological prognostic factors, including histological grade, lymph node status, tumor‑node‑metastasis stage, estrogen and progesterone receptor status, Ki‑67 proliferative index and human epidermal growth factor receptor 2 overexpression, were determined. Mann‑Whitney U test, Spearman's rank‑correlation test and independent‑samples t‑tests were used for evaluation. Core‑needle biopsy or surgical resection specimens of 99 malignant breast lesions were included in the present study. Of the 99 malignant lesions, 44 lesions exhibited homogeneous enhancement, 43 exhibited peripheral enhancement and 12 exhibited regional enhancement. Lesions with peripheral enhancement exhi­bited a higher peripheral/central ratio of MVD compared with lesions with homogeneous enhancement (P<0.001). Peak intensity and ascending slope ratios of tumor periphery/center were correlated with the corresponding MVD ratios (P=0.017 and P=0.016, respectively). MVD ratio was positively correlated with histological grade (P=0.003). In conclusion, the enhancement patterns and parameters of CEUS may not only reflect the microvessel distribution but also indirectly indicate the histological grade of breast cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Li X, Li Y, Zhu Y, Fu L and Liu P: Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer. Oncol Lett 15: 5643-5649, 2018.
APA
Li, X., Li, Y., Zhu, Y., Fu, L., & Liu, P. (2018). Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer. Oncology Letters, 15, 5643-5649. https://doi.org/10.3892/ol.2018.8078
MLA
Li, X., Li, Y., Zhu, Y., Fu, L., Liu, P."Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer". Oncology Letters 15.4 (2018): 5643-5649.
Chicago
Li, X., Li, Y., Zhu, Y., Fu, L., Liu, P."Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer". Oncology Letters 15, no. 4 (2018): 5643-5649. https://doi.org/10.3892/ol.2018.8078
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Li Y, Zhu Y, Fu L and Liu P: Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer. Oncol Lett 15: 5643-5649, 2018.
APA
Li, X., Li, Y., Zhu, Y., Fu, L., & Liu, P. (2018). Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer. Oncology Letters, 15, 5643-5649. https://doi.org/10.3892/ol.2018.8078
MLA
Li, X., Li, Y., Zhu, Y., Fu, L., Liu, P."Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer". Oncology Letters 15.4 (2018): 5643-5649.
Chicago
Li, X., Li, Y., Zhu, Y., Fu, L., Liu, P."Association between enhancement patterns and parameters of contrast‑enhanced ultrasound and microvessel distribution in breast cancer". Oncology Letters 15, no. 4 (2018): 5643-5649. https://doi.org/10.3892/ol.2018.8078
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