Open Access

microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression

  • Authors:
    • Ming Chen
    • Yong‑Yi Liu
    • Min‑Qing Zheng
    • Xin‑Liang Wang
    • Xing‑Hua Gao
    • Lin Chen
    • Guang‑Ming Zhang
  • View Affiliations

  • Published online on: March 8, 2018     https://doi.org/10.3892/ol.2018.8218
  • Pages: 7076-7082
  • Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

microRNAs (miRNAs) perform various oncogenic or tumor suppressor functions in carcinogenesis. Currently, the underlying mechanisms of miRNAs in osteosarcoma (OS) are poorly understood. In the present study, it is demonstrated that expression of miR‑544 was markedly upregulated in OS cells and clinical tissues. Furthermore, overexpression of miR‑544 enhanced OS cell proliferation in vitro. Bioinformatics analysis indicated that miR‑544 may target the 3'‑untranslated region of axis formation inhibitor 2, which was validated using luciferase reporter gene assays. The present study demonstrated a vital role for miR‑544 in promoting OS cell proliferation, indicating that it may represent a novel prognostic factor or therapeutic target for OS.
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May-2018
Volume 15 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chen M, Liu YY, Zheng MQ, Wang XL, Gao XH, Chen L and Zhang GM: microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression. Oncol Lett 15: 7076-7082, 2018.
APA
Chen, M., Liu, Y., Zheng, M., Wang, X., Gao, X., Chen, L., & Zhang, G. (2018). microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression. Oncology Letters, 15, 7076-7082. https://doi.org/10.3892/ol.2018.8218
MLA
Chen, M., Liu, Y., Zheng, M., Wang, X., Gao, X., Chen, L., Zhang, G."microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression". Oncology Letters 15.5 (2018): 7076-7082.
Chicago
Chen, M., Liu, Y., Zheng, M., Wang, X., Gao, X., Chen, L., Zhang, G."microRNA-544 promoted human osteosarcoma cell proliferation by downregulating AXIN2 expression". Oncology Letters 15, no. 5 (2018): 7076-7082. https://doi.org/10.3892/ol.2018.8218