3F‑Box protein 32 degrades ataxia telangiectasia and Rad3‑related and regulates DNA damage response induced by gemcitabine in pancreatic cancer

  • Authors:
    • Chong Yang
    • Ping Fan
    • Shikai Zhu
    • Hongji Yang
    • Xin Jin
    • Heshui Wu
  • View Affiliations

  • Published online on: March 28, 2018     https://doi.org/10.3892/ol.2018.8367
  • Pages: 8878-8884
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Abstract

Ataxia telangiectasia and Rad3‑related (ATR) activates checkpoint kinase 1 (CHK1) following replication fork stalling, leading to cell cycle arrest. ATR‑CHK1 pathway components are considered to be promising therapeutic targets to enhance the effectiveness of replication inhibitors. The present study revealed that F‑Box protein 32 (FBXO32) regulated ATR expression in pancreatic cancer PANC‑1 and MIA PaCa‑2 cells. Additionally, FBXO32 interacts with ATR in PANC‑1 cells and ATR is a degradation substrate of E3 ubiquitin ligase FBXO32. Furthermore, FBXO32 regulated the DNA damage response induced by gemcitabine in PANC‑1 cells. Taken together, the results of the present study suggested that FBXO32, as an E3 ubiquitin ligase of ATR, regulates the DNA damage response induced by gemcitabine in pancreatic cancer.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Yang C, Fan P, Zhu S, Yang H, Jin X and Wu H: 3F‑Box protein 32 degrades ataxia telangiectasia and Rad3‑related and regulates DNA damage response induced by gemcitabine in pancreatic cancer. Oncol Lett 15: 8878-8884, 2018
APA
Yang, C., Fan, P., Zhu, S., Yang, H., Jin, X., & Wu, H. (2018). 3F‑Box protein 32 degrades ataxia telangiectasia and Rad3‑related and regulates DNA damage response induced by gemcitabine in pancreatic cancer. Oncology Letters, 15, 8878-8884. https://doi.org/10.3892/ol.2018.8367
MLA
Yang, C., Fan, P., Zhu, S., Yang, H., Jin, X., Wu, H."3F‑Box protein 32 degrades ataxia telangiectasia and Rad3‑related and regulates DNA damage response induced by gemcitabine in pancreatic cancer". Oncology Letters 15.6 (2018): 8878-8884.
Chicago
Yang, C., Fan, P., Zhu, S., Yang, H., Jin, X., Wu, H."3F‑Box protein 32 degrades ataxia telangiectasia and Rad3‑related and regulates DNA damage response induced by gemcitabine in pancreatic cancer". Oncology Letters 15, no. 6 (2018): 8878-8884. https://doi.org/10.3892/ol.2018.8367