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Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI

  • Authors:
    • Weiwei Zhao
    • Zhiyong Quan
    • Xufang Huang
    • Jing Ren
    • Didi Wen
    • Guangwen Zhang
    • Zhongqiang Shi
    • Hong Yin
    • Yi Huan
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Nuclear Medicine, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, GE Healthcare Co., Ltd., Shanghai 210000, P.R. China
    Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8349-8356
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/ol.2018.8384
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Abstract

The present study aimed to evaluate the diagnostic efficacy of pharmacokinetic parameters derived from dynamic contrast‑enhanced magnetic resonance imaging (DCE‑MRI) in prospective evaluation of pancreatic neuroendocrine neoplasms (pNENs) grading. A total of 25 histologically proven patients with pNENs (30 lesions in total) who underwent DCE‑MRI were enrolled. Lesions were divided into G1, G2 neuroendocrine tumor (NET) and G3 NET/neuroendocrine carcinoma (NEC) groups based on their histological findings according to 2017 World Health Organization Neuroendocrine Tumor Classification Guideline. In addition, the same numbers of tumor‑free regions were selected using as normal control group. For each group, pharmacokinetic DCE parameters: volume transfer constant (Ktrans); contrast transfer rate constant (kep); extravascular extracellular space volume fraction (ve); and plasma volume fraction (vp) were calculated with Extended Tofts Linear model. Receiver operator characteristics analysis was conducted to assess the diagnostic efficacy of these parameters in pNENs grading. There were significant differences of Ktrans, kep, ve and vp between tumor‑free areas and G1, G2 NET (P<0.001). The Ktrans and kep of G1 NET were significantly lower compared with those of G2 ones (P<0.005). The area under the curve of Ktrans and kep in differentiating G2 from G1 NET were 0.767 and 0.846, respectively. When Ktrans was >0.667 and kep >1.644, the sensitivity of diagnosing G2 NET was the lowest (53.85%), but the specificity was the highest (93.75%). When Ktrans was >0.667 or kep >1.644, the sensitivity of diagnosing G2 NET was 92.31%, but the specificity was 75.00%. Pharmacokinetic parameters of DCE‑MRI, particularly the quantitative values of Ktrans and kep, are helpful for differentiating G2 NET from G1 ones.
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1 

Yao JC, Hassan M, Phan A, Dagohoy C, Leary C, Mares JE, Abdalla EK, Fleming JB, Vauthey JN, Rashid A and Evans DB: One hundred years after ‘carcinoid’: Epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol. 26:3063–3072. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Dong M, Phan AT and Yao JC: New strategies for advanced neuroendocrine tumors in the era of targeted therapy. Clin Cancer Res. 18:1830–1836. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Halfdanarson TR, Rabe KG, Rubin J and Petersen GM: Pancreatic neuroendocrine tumors (PNETs): Incidence, prognosis and recent trend toward improved survival. Ann Oncol. 19:1727–1733. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Kim JY, Hong SM and Ro JY: Recent updates on grading and classification of neuroendocrine tumors. Ann Diagn Pathol. 29:11–16. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Boudreaux JP, Klimstra DS, Hassan MM, Woltering EA, Jensen RT, Goldsmith SJ, Nutting C, Bushnell DL, Caplin ME and Yao JC: North American Neuroendocrine Tumor Society (NANETS): The NANETS consensus guideline for the diagnosis and management of neuroendocrine tumors: Well-differentiated neuroendocrine tumors of the jejunum, ileum, appendix, and cecum. Pancreas. 39:753–766. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Crippa S, Partelli S, Bassi C, Berardi R, Capelli P, Scarpa A, Zamboni G and Falconi M: Long-term outcomes and prognostic factors in neuroendocrine carcinomas of the pancreas: Morphology matters. Surgery. 159:862–871. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Crippa S, Partelli S, Belfiori G, Palucci M, Muffatti F, Adamenko O, Cardinali L, Doglioni C, Zamboni G and Falconi M: Management of neuroendocrine carcinomas of the pancreas (WHO G3): A tailored approach between proliferation and morphology. World J Gastroenterol. 22:9944–9953. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Sorbye H, Strosberg J, Baudin E, Klimstra DS and Yao JC: Gastroenteropancreatic high-grade neuroendocrine carcinoma. Cancer. 120:2814–2823. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Kunz PL, Reidy-Lagunes D, Anthony LB, Bertino EM, Brendtro K, Chan JA, Chen H, Jensen RT, Kim MK, Klimstra DS, et al: Consensus guidelines for the management and treatment of neuroendocrine tumors. Pancreas. 42:557–577. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Kim DW, Kim HJ, Kim KW, Byun JH, Song KB, Kim JH and Hong SM: Neuroendocrine neoplasms of the pancreas at dynamic enhanced CT: Comparison between grade 3 neuroendocrine carcinoma and grade 1/2 neuroendocrine tumour. Eur Radiol. 25:1375–1383. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Kim JH, Eun HW, Kim YJ, Han JK and Choi BI: Staging accuracy of MR for pancreatic neuroendocrine tumor and imaging findings according to the tumor grade. Abdom Imaging. 38:1106–1114. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Jang KM, Kim SH, Lee SJ and Choi D: The value of gadoxetic acid-enhanced and diffusion-weighted MRI for prediction of grading of pancreatic neuroendocrine tumors. Acta Radiol. 55:140–148. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, Larsson HB, Lee TY, Mayr NA, Parker GJ, et al: Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: Standardized quantities and symbols. J Magn Reson Imaging. 10:223–232. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Morgan B, Thomas AL, Drevs J, Hennig J, Buchert M, Jivan A, Horsfield MA, Mross K, Ball HA, Lee L, et al: Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: Results from two phase I studies. J Clin Oncol. 21:3955–3964. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Cho E, Chung DJ, Yeo DM, Sohn D, Son Y, Kim T and Hahn ST: Optimal cut-off value of perfusion parameters for diagnosing prostate cancer and for assessing aggressiveness associated with Gleason score. Clin Imaging. 39:834–840. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Park JJ, Kim CK, Park SY, Simonetti AW, Kim E, Park BK and Huh SJ: Assessment of early response to concurrent chemoradiotherapy in cervical cancer: Value of diffusion-weighted and dynamic contrast-enhanced MR imaging. Magn Reson Imaging. 32:993–1000. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Chakiba C, Cornelis F, Descat E, Gross-Goupil M, Sargos P, Roubaud G and Houédé N: Dynamic contrast enhanced MRI-derived parameters are potential biomarkers of therapeutic response in bladder carcinoma. Eur J Radiol. 84:1023–1028. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Furukawa M, Parvathaneni U, Maravilla K, Richards TL and Anzai Y: Dynamic contrast-enhanced MR perfusion imaging of head and neck tumors at 3 Tesla. Head Neck. 35:923–929. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Huang B, Wong CS, Whitcher B, Kwong DL, Lai V, Chan Q and Khong PL: Dynamic contrast-enhanced magnetic resonance imaging for characterising nasopharyngeal carcinoma: Comparison of semiquantitative and quantitative parameters and correlation with tumour stage. Eur Radiol. 23:1495–1502. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Yuan Y, Kuai YP, Chen XS and Tao XF: Assessment of dynamic contrast-enhanced magnetic resonance imaging in the differentiation of malignant from benign orbital masses. Eur J Radiol. 82:1506–1511. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Koo HR, Cho N, Song IC, Kim H, Chang JM, Yi A, Yun BL and Moon WK: Correlation of perfusion parameters on dynamic contrast-enhanced MRI with prognostic factors and subtypes of breast cancers. J Magn Reson Imaging. 36:145–151. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Joo I, Lee JM, Han JK, Yang HK, Lee HJ and Choi BI: Dynamic contrast-enhanced MRI of gastric cancer: Correlation of the perfusion parameters with pathological prognostic factors. J Magn Reson Imaging. 41:1608–1614. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Filice S and Crisi G: Dynamic contrast-enhanced perfusion MRI of high grade brain gliomas obtained with arterial or venous waveform input function. J Neuroimaging. 26:124–129. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Handayani A, Triadyaksa P, Dijkstra H, Pelgrim GL, van Ooijen PM, Prakken NH, Schoepf UJ, Oudkerk M, Vliegenthart R and Sijens PE: Intermodel agreement of myocardial blood flow estimation from stress-rest myocardial perfusion magnetic resonance imaging in patients with coronary artery disease. Invest Radiol. 50:275–282. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Jennings D, Raghunand N and Gillies RJ: Imaging hemodynamics. Cancer Metastasis Rev. 27:589–613. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Turkbey B, Kobayashi H, Ogawa M, Bernardo M and Choyke PL: Imaging of tumor angiogenesis: Functional or targeted? AJR Am J Roentgenol. 193:304–313. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao W, Quan Z, Huang X, Ren J, Wen D, Zhang G, Shi Z, Yin H and Huan Y: Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI. Oncol Lett 15: 8349-8356, 2018.
APA
Zhao, W., Quan, Z., Huang, X., Ren, J., Wen, D., Zhang, G. ... Huan, Y. (2018). Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI. Oncology Letters, 15, 8349-8356. https://doi.org/10.3892/ol.2018.8384
MLA
Zhao, W., Quan, Z., Huang, X., Ren, J., Wen, D., Zhang, G., Shi, Z., Yin, H., Huan, Y."Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI". Oncology Letters 15.6 (2018): 8349-8356.
Chicago
Zhao, W., Quan, Z., Huang, X., Ren, J., Wen, D., Zhang, G., Shi, Z., Yin, H., Huan, Y."Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI". Oncology Letters 15, no. 6 (2018): 8349-8356. https://doi.org/10.3892/ol.2018.8384
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao W, Quan Z, Huang X, Ren J, Wen D, Zhang G, Shi Z, Yin H and Huan Y: Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI. Oncol Lett 15: 8349-8356, 2018.
APA
Zhao, W., Quan, Z., Huang, X., Ren, J., Wen, D., Zhang, G. ... Huan, Y. (2018). Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI. Oncology Letters, 15, 8349-8356. https://doi.org/10.3892/ol.2018.8384
MLA
Zhao, W., Quan, Z., Huang, X., Ren, J., Wen, D., Zhang, G., Shi, Z., Yin, H., Huan, Y."Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI". Oncology Letters 15.6 (2018): 8349-8356.
Chicago
Zhao, W., Quan, Z., Huang, X., Ren, J., Wen, D., Zhang, G., Shi, Z., Yin, H., Huan, Y."Grading of pancreatic neuroendocrine neoplasms using pharmacokinetic parameters derived from dynamic contrast‑enhanced MRI". Oncology Letters 15, no. 6 (2018): 8349-8356. https://doi.org/10.3892/ol.2018.8384
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