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Article

Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer

  • Authors:
    • Wen‑Liang Qiao
    • Bo‑Wen Shi
    • Yu‑Dong Han
    • Hua‑Mei Tang
    • Jun Lin
    • Hai‑Yang Hu
    • Qiang Lin
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P.R. China, Department of Pathology, Shanghai First People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, P.R. China
  • Pages: 8796-8804
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/ol.2018.8387
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Abstract

Testes‑specific protease 50 (TSP50) is normally expressed in the testes and is overexpressed in various types of human cancers, including breast cancer, colorectal carcinoma and laryngocarcinoma. However, little has been reported on the association between TSP50 and non‑small cell lung cancer (NSCLC). The present study aimed to detect TSP50 expression in 198 strict follow‑up cases of paired NSCLC and 15 cases of normal lung parenchymal specimens using immunohistochemical staining. The expression levels of TSP50 were then correlated with the clinicopathological factors of NSCLC to assess its potential diagnostic and prognostic value. The relationship between TSP50 expression and the clinicopathological parameters of NSCLC was evaluated using χ2 and Fisher's exact tests. Survival rates for the overall population (n=198) were calculated using the Kaplan‑Meier method, and univariate and multivariate analyses were performed using the Cox's proportional hazards regression model. P<0.05 was considered to indicate a statistically significant difference. The expression of TSP50 was significantly increased in NSCLC tissue compared with in adjacent non‑tumor or normal lung parenchymal tissue (P<0.001). A significant association was revealed between high expression levels of TSP50 and clinicopathological characteristics including tumor differentiation (P=0.012), late tumor status (P=0.004) and late tumor node metastasis stage (P=0.026), as well as a reduced disease free survival (P=0.009) and overall survival rate (P=0.002) in all patients with NSCLC. Multivariate analyses demonstrated that high TSP50 expression in tumor tissues was significantly associated with a shorter disease‑free survival rate [hazard ratio (HR) =1.590, 95% confidence interval (CI): 1.035‑2.441], and with a shorter overall survival rate (HR=1.814; 95% CI: 1.156‑2.846). In conclusion, the present data demonstrated that increased TSP50 protein expression may be a potential predictor of early recurrence and poor prognosis in NSCLC, and that TSP50 expression levels possess the potential to be used as a biomarker and therapeutic target for the treatment of patients with NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Qiao WL, Shi BW, Han YD, Tang HM, Lin J, Hu HY and Lin Q: Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer. Oncol Lett 15: 8796-8804, 2018.
APA
Qiao, W., Shi, B., Han, Y., Tang, H., Lin, J., Hu, H., & Lin, Q. (2018). Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer. Oncology Letters, 15, 8796-8804. https://doi.org/10.3892/ol.2018.8387
MLA
Qiao, W., Shi, B., Han, Y., Tang, H., Lin, J., Hu, H., Lin, Q."Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer". Oncology Letters 15.6 (2018): 8796-8804.
Chicago
Qiao, W., Shi, B., Han, Y., Tang, H., Lin, J., Hu, H., Lin, Q."Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer". Oncology Letters 15, no. 6 (2018): 8796-8804. https://doi.org/10.3892/ol.2018.8387
Copy and paste a formatted citation
x
Spandidos Publications style
Qiao WL, Shi BW, Han YD, Tang HM, Lin J, Hu HY and Lin Q: Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer. Oncol Lett 15: 8796-8804, 2018.
APA
Qiao, W., Shi, B., Han, Y., Tang, H., Lin, J., Hu, H., & Lin, Q. (2018). Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer. Oncology Letters, 15, 8796-8804. https://doi.org/10.3892/ol.2018.8387
MLA
Qiao, W., Shi, B., Han, Y., Tang, H., Lin, J., Hu, H., Lin, Q."Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer". Oncology Letters 15.6 (2018): 8796-8804.
Chicago
Qiao, W., Shi, B., Han, Y., Tang, H., Lin, J., Hu, H., Lin, Q."Testes‑specific protease 50 as an independent risk factor for poor prognosis in patients with non‑small cell lung cancer". Oncology Letters 15, no. 6 (2018): 8796-8804. https://doi.org/10.3892/ol.2018.8387
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