Analysis of the clinicopathological features and prognostic factors of primary hepatic neuroendocrine tumors

Chen,Ren‑Wang; Qiu,Meng‑Jun; Chen,Yaobing; Zhang,Tao; He,Xiao‑Xiao; Li,Ying; Sun,Wen‑Jia; Xie,Tao; Yang,Sheng‑Li; Hu,Jian‑Li

doi:10.3892/ol.2018.8413

June-2018 Volume 15 Issue 6

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June-2018 Volume 15 Issue 6

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Article Open Access

Analysis of the clinicopathological features and prognostic factors of primary hepatic neuroendocrine tumors

Authors:
- Ren‑Wang Chen
- Meng‑Jun Qiu
- Yaobing Chen
- Tao Zhang
- Xiao‑Xiao He
- Ying Li
- Wen‑Jia Sun
- Tao Xie
- Sheng‑Li Yang
- Jian‑Li Hu
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Affiliations: Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Division of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430077, P.R. China, Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China, Department of Radiation Oncology, Hubei Cancer Hospital, Wuhan, Hubei 430070, P.R. China

Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 8604-8610
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Published online on: April 2, 2018

https://doi.org/10.3892/ol.2018.8413
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Abstract

Neuroendocrine tumors (NETs) of the gastrointestinal tract often spread to the liver, while primary hepatic NETs (PHNETs), first described by Edmondson in 1958, are very rare. The majority of existing reports regarding PHNETs have small sample sizes, and the clinicopathological characteristics and prognostic factors are still unclear. The aim of the present study was to analyze the clinicopathological features and explore the prognostic factors of PHNETs. From March 2012 to March 2017, 28 cases of PHNETs were retrospectively evaluated to analyze the clinicopathological features and explore the prognostic factors of PHNETs. The 28 PHNETs patients were males (n=15) and females (n=13) aged between 32 and 76 years (mean=53 years). Among them, 16 patients had clinical symptoms. The remaining 12 patients had no obvious clinical symptoms, only hepatoncus was observed during physical examination. Single‑factor analysis showed that carbohydrate antigen 125 (CA125), alanine aminotransferase (ALT), aspartate aminotransferase (AST), hemoglobin (HB), Ki‑67 positive index (PI), surgical treatment and pathological grading were correlated to PHNET prognosis (P<0.05); multifactor analysis revealed that Ki‑67 PI was associated with the prognosis (P<0.05). Thus, the prognosis of PHNETs may be effectively predicted using the indexes of CA125, ALT, AST, HB, Ki‑67 PI, pathological grading and surgical treatment. Pathological classification of grade 3, high expression of Ki‑67 PI, abnormal elevation of CA125, abnormalities of ALT and AST, anemia and lack of radical operation indicated a poor prognosis. High expression of Ki‑67 PI was an independent prognostic factor for PHNETs.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Analysis of the clinicopathological features and prognostic factors of primary hepatic neuroendocrine tumors

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