The roles of RUNX3 in cervical cancer cells in vitro

Corrigendum in: /10.3892/ol.2019.9883

  • Authors:
    • Zhen Li
    • Pan Fan
    • Min Deng
    • Chao Zeng
  • View Affiliations

  • Published online on: April 4, 2018     https://doi.org/10.3892/ol.2018.8419
  • Pages: 8729-8734
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

RUNX3 serves an important role in development of various types of human cancer. The purpose of the present study was to investigate the potential biological function of RUNX3 in cervical cancer cells. In the present study, a RUNX3 overexpressed model was constructed in Hec1 cells by PCDNA3.1‑RUNX3 transfection. Western blot analysis was used to measure RUNX3 expression in cervical cancer cells. Immunofluorescence analysis was performed to examine subcellular localization of RUNX3 in cervical cancer cells. Effects of RUNX3 expression on proliferation, migration and invasion of cervical cancer cells were detected by colony formation assay, wound healing assay and Transwell assay, respectively. Immunofluorescence confirmed the nuclear location of RUNX3 in cervical cancer cell. Result sindicated that upregulation of RUNX3 expression inhibited proliferation, migration and invasion of cervical cancer cells. However, knockdown of RUNX3 expression promoted the proliferation, migration and invasion of cervical cancer cells. Hence, RUNX3 may serve as a tumor suppressor gene in cervical cancer.
View Figures
View References

Related Articles

Journal Cover

June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Fan P, Deng M and Zeng C: The roles of RUNX3 in cervical cancer cells in vitro Corrigendum in /10.3892/ol.2019.9883. Oncol Lett 15: 8729-8734, 2018
APA
Li, Z., Fan, P., Deng, M., & Zeng, C. (2018). The roles of RUNX3 in cervical cancer cells in vitro Corrigendum in /10.3892/ol.2019.9883. Oncology Letters, 15, 8729-8734. https://doi.org/10.3892/ol.2018.8419
MLA
Li, Z., Fan, P., Deng, M., Zeng, C."The roles of RUNX3 in cervical cancer cells in vitro Corrigendum in /10.3892/ol.2019.9883". Oncology Letters 15.6 (2018): 8729-8734.
Chicago
Li, Z., Fan, P., Deng, M., Zeng, C."The roles of RUNX3 in cervical cancer cells in vitro Corrigendum in /10.3892/ol.2019.9883". Oncology Letters 15, no. 6 (2018): 8729-8734. https://doi.org/10.3892/ol.2018.8419