Open Access

Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile

  • Authors:
    • Hailong Liang
    • Xiangyang Chu
    • Jing Zhao
    • Guosheng Xing
    • Yingjian Si
  • View Affiliations

  • Published online on: April 4, 2018     https://doi.org/10.3892/ol.2018.8424
  • Pages: 8387-8395
  • Copyright : © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].

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Abstract

It has been established that the tumor microenvironment (TME) has a crucial role in enabling tumors to evade from host immune responses. Previous studies demonstrated that tumor cells are not only able to reshape immune milieu at the tumor site, but also exert systemic effects, which has been demonstrated to be important for metastasis. At present, how the peripheral immune environment change in the tumor‑bearing host is unclear. The present study identified a number of changes in the proportions of lymphocyte subpopulations and the levels of cytokines in patients with NSCLC, which may provide a preliminary profile of the immune environment in the peripheral blood of patients harboring a tumor. These findings expand on the present knowledge on how tumors can alter the immune system to benefit its growth and metastasis, which may provide a potential novel strategy for immunotherapy.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liang H, Chu X, Zhao J, Xing G and Si Y: Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile. Oncol Lett 15: 8387-8395, 2018
APA
Liang, H., Chu, X., Zhao, J., Xing, G., & Si, Y. (2018). Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile. Oncology Letters, 15, 8387-8395. https://doi.org/10.3892/ol.2018.8424
MLA
Liang, H., Chu, X., Zhao, J., Xing, G., Si, Y."Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile". Oncology Letters 15.6 (2018): 8387-8395.
Chicago
Liang, H., Chu, X., Zhao, J., Xing, G., Si, Y."Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile". Oncology Letters 15, no. 6 (2018): 8387-8395. https://doi.org/10.3892/ol.2018.8424