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Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile

  • Authors:
    • Hailong Liang
    • Xiangyang Chu
    • Jing Zhao
    • Guosheng Xing
    • Yingjian Si
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, General Hospital of People's Liberation Army, Beijing 100853, P.R. China, Department of Thoracic Surgery, General Hospital of Beijing Command, Beijing 100700, P.R. China, Department of Pediatrics, General Hospital of Beijing Command, Beijing 100700, P.R. China
    Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY 4.0].
  • Pages: 8387-8395
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    Published online on: April 4, 2018
       https://doi.org/10.3892/ol.2018.8424
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Abstract

It has been established that the tumor microenvironment (TME) has a crucial role in enabling tumors to evade from host immune responses. Previous studies demonstrated that tumor cells are not only able to reshape immune milieu at the tumor site, but also exert systemic effects, which has been demonstrated to be important for metastasis. At present, how the peripheral immune environment change in the tumor‑bearing host is unclear. The present study identified a number of changes in the proportions of lymphocyte subpopulations and the levels of cytokines in patients with NSCLC, which may provide a preliminary profile of the immune environment in the peripheral blood of patients harboring a tumor. These findings expand on the present knowledge on how tumors can alter the immune system to benefit its growth and metastasis, which may provide a potential novel strategy for immunotherapy.
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1 

Gross L: Intradermal immunization of C3H mice against a sarcoma that originated in an animal of the same line. Cancer Res. 3:326–333. 1943.

2 

Prehn RT and Main JM: Immunity to methylcholanthrene-induced sarcomas. J Natl Cancer Inst. 18:769–778. 1957.PubMed/NCBI

3 

Hewitt HB, Blake ER and Walder AS: A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin. Br J Cancer. 33:241–259. 1976. View Article : Google Scholar : PubMed/NCBI

4 

Klein G and Klein E: Immune surveillance against virus-induced tumors and nonrejectability of spontaneous tumors: Contrasting consequences of host versus tumor evolution. Proc Natl Acad Sci USA. 74:2121–2125. 1977. View Article : Google Scholar : PubMed/NCBI

5 

Schreiber RD, Old LJ and Smyth MJ: Cancer immunoediting: Integrating immunity's roles in cancer suppression and promotion. Science. 331:1565–1570. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Chen F, Zhuang X, Lin L, Yu P, Wang Y, Shi Y, Hu G and Sun Y: New horizons in tumor microenvironment biology: Challenges and opportunities. BMC Med. 13:452015. View Article : Google Scholar : PubMed/NCBI

7 

Swartz MA, Iida N, Yull FE, Roberts EW, Sangaletti S, Wong MH, Yull FE, Coussens LM and DeClerck YA: Tumor microenvironment complexity: Emerging roles in cancer therapy. Cancer Res. 72:2473–2480. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Lindau D, Gielen P, Kroesen M, Wesseling P and Adema GJ: The immunosuppressive tumour network: Myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology. 138:105–115. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Obeid E, Nanda R, Fu YX and Olopade OI: The role of tumor-associated macrophages in breast cancer progression (Review). Int J Oncol. 43:5–12. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Shiga K, Hara M, Nagasaki T, Sato T, Takahashi H and Takeyama H: Cancer-associated fibroblasts: Their characteristics and their roles in tumor growth. Cancer (Basel). 7:2443–2458. 2015. View Article : Google Scholar

11 

Anderson AC, Joller N and Kuchroo VK: Lag-3, Tim-3, and TIGIT: Co-inhibitory receptors with specialized functions in immune regulations. Immunity. 44:989–1004. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Smigiel KS, Srivastava S, Stolley JM and Campbell DJ: Regulatory T-cell homeostasis: Steady-state maintenance and modulation during inflammation. Immunol Rev. 259:40–45. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Ott PA, Hodi FS and Robert C: CTLA-4 and PD-1/PD-L1blockade: New immunotherapeutic modalities with durable clinical benefit in melanoma patients. Clin Cancer Res. 19:5300–5309. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Romano E and Romero P: The therapeutic promise of disrupting the PD-1/PD-L1 immune checkpoint in cancer: Unleashing the CD8 T cell mediated anti-tumor activity results in significant, unprecedented clinical efficacy in various solid tumors. J Immunother Cancer. 3:152015. View Article : Google Scholar : PubMed/NCBI

15 

Mitchem JB, Brennan DJ, Knolhoff BL, Belt BA, Zhu Y, Sanford DE, Belaygorod L, Carpenter D, Collins L, Piwnica-Worms D, et al: Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression and improves chemotherapeutics responses. Cancer Res. 73:1128–1141. 2013. View Article : Google Scholar : PubMed/NCBI

16 

McAllister SS and Weinberg RA: The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis. Nat Cell Biol. 16:717–727. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Hiratsuka S, Nakamura K, Iwai S, Murakami M, Itoh T, Kijima H, Shipley JM, Senior RM and Shibuya M: MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis. Cancer Cell. 2:289–300. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, et al: VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 438:820–827. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Hiratsuka S, Watanabe A, Aburatani H and Maru Y: Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol. 8:1369–1375. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT and Giaccia AJ: Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 15:35–44. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Kim S, Takahashi H, Lin WW, Descargues P, Grivennikov S, Kim Y, Luo JL and Karin M: Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis. Nature. 457:102–106. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Sceneay J, Chow MT, Chen A, Halse HM, Wong CS, Andrews DM, Sloan EK, Parker BS, Bowtell DD, Smyth MJ and Möller A: Primary tumor hypoxia recruits CD11b+/Ly6Cmed/Ly6G+ immune suppressor cells and compromises NK cell cytotoxicity in the premetastatic niche. Cancer Res. 72:3906–3911. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Kang SY, Halvorsen OJ, Gravdal K, Bhattacharya N, Lee JM, Liu NW, Johnston BT, Johnston AB, Haukaas SA, Aamodt K, et al: Prosaposin inhibits tumor metastasis via paracrine and endocrine stimulation of stromal p53 and Tsp-1. Proc Natl Acad Sci USA. 106:12115–12120. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Granot Z, Henke E, Comen EA, King TA, Norton L and Benezra R: Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell. 20:300–314. 2011. View Article : Google Scholar : PubMed/NCBI

25 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Kurusu Y, Yamashita J and Ogawa M: Detection of circulating tumor cells by reverse transcriptasepolymerase chain reaction in patients with resectable non-small-cell lung cancer. Surgery. 126:820–826. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Grabenbauer GG, Lahmer G, Distel L and Niedobitek G: Tumor-infiltrating cytotoxic T cells but not regulatory T cells predict outcome in anal squamous cell carcinoma. Clin Cancer Res. 12:3355–3360. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Mellman I, Coukos G and Dranoff G: Cancer immunotherapy comes of age. Nature. 480:480–489. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Friedl P and Alexander S: Cancer invasion and the microenvironment: Plasticity and reciprocity. Cell. 147:992–1009. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Pietras K and Ostman A: Hallmarks of cancer: Interactions with the tumor stroma. Exp Cell Res. 316:1324–1331. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Carlini MJ, De Lorenzo MS and Puricelli L: Cross-talk between tumor cells and the microenvironment at the metastatic niche. Curr Pharm Biotechnol. 12:1900–1908. 2011. View Article : Google Scholar : PubMed/NCBI

32 

McAllister SS, Gifford AM, Greiner AL, Kelleher SP, Saelzler MP, Ince TA, Reinhardt F, Harris LN, Hylander BL, Repasky EA and Weinberg RA: Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell. 133:994–1005. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, Evdemon-Hogan M, Conejo-Garcia JR, Zhang L, Burow M, et al: Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med. 10:942–949. 2014. View Article : Google Scholar

34 

Jóźwicki W, Brożyna AA, Siekiera J and Slominski AT: Frequency of CD4+CD25+Foxp3+ cells in peripheral blood in relation to urinary bladder cancer malignancy indicators before and after surgical removal. Oncotraget. 7:11450–11462. 2016.

35 

Fogar P, Sperti C, Basso D, Sanzari MC, Greco E, Davoli C, Navaglia F, Zambon CF, Pasquali C, Venza E, et al: Decreased total lymphocyte counts in pancreatic cancer: An index of adverse outcome. Pancreas. 32:22–28. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Ahmad SS, Akhtar K, Verma AK, Mallik AZ and Siddiqui SA: Total peripheral lymphocyte count in malignant tumors: An index of prognostication. J Med Sci. 12:24–28. 2012. View Article : Google Scholar

37 

Ray-Coquard I, Cropet C, Van Glabbeke M, Sebban C, Le Cesne A, Judson I, Tredan O, Verweij J, Biron P, Labidi I, et al: Lymphopenia as a prognostic factor for overall survival in advanced carcinomas, sarcomas, and lymphomas. Cancer Res. 69:5383–5391. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Fischer K, Voelkl S, Heymann J, Przybylski GK, Mondal K, Laumer M, Kunz-Schughart L, Schmidt CA, Andreesen R and Mackensen A: Isolation and characterization of human antigen-specific TCR alpha beta+ CD4 (-)CD8- double-negative regulatory T cells. Blood. 105:2828–2835. 2015. View Article : Google Scholar

39 

Thomson CW, Lee BP and Zhang L: Double-negative regulatory T cells: Non-conventional regulators. Immunol Res. 35:163–178. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Priatel JJ, Utting O and Teh HS: TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J Immunol. 167:6188–6194. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Voelkl S, Gary R and Mackensen A: Characterization of the immunoregulatory function of human TCR-αβ+ CD4-CD8- double-negative T cells. Eur J Immunol. 41:739–748. 2011. View Article : Google Scholar : PubMed/NCBI

42 

Ligocki AJ and Niederkorn JY: Advances on Non-CD4+Foxp3+T regulatory cells: CD8+, Type1, and double negative t regulatory cells in organ transplantation. Transplantation. 99:1553–1559. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Sundaravaradan V, Mir KD and Sodora DL: Double-negative T cells during HIV/SIV infections: Potential pinch hitters in the T cell lineup. Curr Opin HIV AIDS. 7:164–171. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Young KJ, Kay LS, Phillips MJ and Zhang L: Antitumor activity mediated by double-negative T cells. Cancer Res. 63:8014–8021. 2003.PubMed/NCBI

45 

Merims S, Li X, Joe B, Dokouhaki P, Han M, Childs RW, Wang ZY, Gupta V, Minden MD and Zhang L: Anti-leukemia effect of ex vivo expanded DNT cells from AML patients: A potential novel autologous T-cell adoptive immunotherapy. Leukemia. 25:1415–1422. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Voelkl S, Moore TV, Rehli M, Nishimura MI, Mackensen A and Fischer K: Characterization of MHC class-I restricted TCR+ CD4-CD8-double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination. Cancer Immunol Immunother. 58:709–718. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Qin Z, Richter G, Schüler T, Ibe S, Cao X and Blankenstein T: B cells inhibit induction of T cell-dependent tumor immunity. Nat Med. 4:627–630. 1998. View Article : Google Scholar : PubMed/NCBI

48 

Shah S, Divekar AA, Hilchey SP, Cho HM, Newman CL, Shin SU, Nechustan H, Challita-Eid PM, Segal BM, Yi KH and Rosenblatt JD: Increased rejection of primary tumors in mice lacking B cells: Inhibition of antitumor CTL and TH1 cytokine responses by B cells. Int J Cancer. 117:574–586. 2005. View Article : Google Scholar : PubMed/NCBI

49 

Lee-Chang C, Bodogai M, Martin-Montalvo A, Wejksza K, Sanghvi M, Moaddel R, de Cabo R and Biragyn A: Inhibition of breast cancer metastasis by resveratrol-mediated inactivation of tumor-evoked regulatory B cells. J Immunol. 191:4141–4151. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Zhang Y, Eliav Y, Shin SU, Schreiber TH, Podack ER, Tadmor T and Rosenblatt JD: B lymphocyte inhibition of anti-tumor response depends on expansion of Treg but is independent of B-cell IL-10 secretion. Cancer Immunol Immunother. 62:87–89. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Cunningham RC: Autoimmunity in primary immune deficiency: Taking lessons from our patients. Clin Exp Immunol. 164 Suppl 2:S6–S11. 2011. View Article : Google Scholar

52 

Harris DP, Haynes L, Sayles PC, Duso DK, Eaton SM, Lepak NM, Johnson LL, Swain SL and Lund FE: Reciprocal regulation of polarized cytokine production by effector B and T cells. Nat Immunol. 1:4752000. View Article : Google Scholar : PubMed/NCBI

53 

Olkhanud PB, Damdinsuren B, Bodogai M, Gress RE, Sen R, Wejksza K, Wersto RP and Biragyn A: Tumor evoked regulatory B cells promote breast cancer metastasis by converting resting CD4+ T cells to T-regulatory cells. Cancer Res. 71:3505–3515. 2011. View Article : Google Scholar : PubMed/NCBI

54 

Milne K, Köbel M, Kalloger SE, Barnes RO, Gao D, Gilks CB, Watson PH and Nelson BH: Systematic analysis of immune infiltrates in high-grade serous ovarian cancer reveals CD20, FoxP3 and TIA-1 as positive prognostic factors. PLoS One. 4:e64122009. View Article : Google Scholar : PubMed/NCBI

55 

Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K and Matsushita T: B cells promote tumor immunity against B16F10 melanoma. Am J Pathol. 184:3120–3129. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Fisher DT, Appenheimer MM and Evans SS: The two faces of IL-6 in the tumor microenvironment. Semin Immunlo. 26:38–47. 2014. View Article : Google Scholar

57 

Lippitz BE: Cytokine patterns in patients with cancer: A systematic review. Lancet Oncol. 14:e218–e228. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liang H, Chu X, Zhao J, Xing G and Si Y: Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile. Oncol Lett 15: 8387-8395, 2018.
APA
Liang, H., Chu, X., Zhao, J., Xing, G., & Si, Y. (2018). Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile. Oncology Letters, 15, 8387-8395. https://doi.org/10.3892/ol.2018.8424
MLA
Liang, H., Chu, X., Zhao, J., Xing, G., Si, Y."Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile". Oncology Letters 15.6 (2018): 8387-8395.
Chicago
Liang, H., Chu, X., Zhao, J., Xing, G., Si, Y."Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile". Oncology Letters 15, no. 6 (2018): 8387-8395. https://doi.org/10.3892/ol.2018.8424
Copy and paste a formatted citation
x
Spandidos Publications style
Liang H, Chu X, Zhao J, Xing G and Si Y: Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile. Oncol Lett 15: 8387-8395, 2018.
APA
Liang, H., Chu, X., Zhao, J., Xing, G., & Si, Y. (2018). Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile. Oncology Letters, 15, 8387-8395. https://doi.org/10.3892/ol.2018.8424
MLA
Liang, H., Chu, X., Zhao, J., Xing, G., Si, Y."Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile". Oncology Letters 15.6 (2018): 8387-8395.
Chicago
Liang, H., Chu, X., Zhao, J., Xing, G., Si, Y."Elevated peripheral blood B lymphocytes and CD3+CD4‑CD8‑ T lymphocytes in patients with non‑small cell lung cancer: A preliminary study on peripheral immune profile". Oncology Letters 15, no. 6 (2018): 8387-8395. https://doi.org/10.3892/ol.2018.8424
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