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Article Open Access

lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer

  • Authors:
    • Qing Li
    • Juan Zhang
    • Juan Zhou
    • Binglie Yang
    • Pingping Liu
    • Lei Cao
    • Lei Jing
    • Hua Liu
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China, Department of Pathology, Affiliated Nanjing Maternal and Child Health Hospital, Nanjing Medical University, Nanjing, Jiangsu 210004, P.R. China, Department of Gynecology and Obstetrics, Shanghai Pudong New Area People's Hospital, Shanghai 201299, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8363-8370
    |
    Published online on: April 4, 2018
       https://doi.org/10.3892/ol.2018.8433
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Abstract

Cisplatin‑resistant ovarian cancer occurs in patients with ovarian cancer treated with cisplatin‑based chemotherapy, which results in tumor progression during treatment, or recurrence of the tumor within 6 months of the treatment. It is vital that a novel biomarker for diagnosis, or an efficient therapeutic target of cisplatin‑resistant ovarian is identified. Long non‑coding (lnc)RNAs were determined to serve critical functions in a variety of distinct types of cancer, including ovarian cancer; however, there is limited knowledge regarding the differential expression levels of lncRNAs in cisplatin‑resistant and cisplatin‑sensitive ovarian cancer. Therefore, in the present study, the expression levels were determined for these cancer types. The lncRNA expression profile in cisplatin‑resistant ovarian cancer was analyzed and compared with the results for cisplatin‑sensitive ovarian cancer; gene ontology and pathway analysis demonstrated that the dysregulated lncRNAs participated in important biological processes. Subsequently, it was identified that these dysregulated lncRNAs were present in other ovarian cancer tissues and in SKOV3 ovarian cancer cells, as well as its cisplatin‑resistant clone, SKOV3/CDDP. In addition, it was revealed that 8 lncRNAs (Enst0000435726, Enst00000585612, Enst00000566734, Enst00000453783, NR_023915, RP11_697E22.2, uc010jub.1 and tcons_00008505) were associated with cisplatin‑resistant ovarian cancer. The present study may assist in improving understanding of the initiation and developmental mechanisms underlying cisplatin‑resistant ovarian cancer, which could aid future studies in discovering potential biomarkers for diagnosis or therapeutic targets that may be used in clinical treatment.
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View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics 2012. CA Cancer J Clin. 62:10–29. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Coleman RL, Monk BJ, Sood AK and Herzog TJ: Latest research and treatment of advanced-stage epithelial ovarian cancer. Nat Rev Clin Oncol. 10:211–224. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Mo L, Pospichalova V, Huang Z, Murphy SK, Payne S, Wang F, Kennedy M, Cianciolo GJ, Bryja V, Pizzo SV and Bachelder RE: Ascites increases expression/function of multidrug resistance proteins in ovarian cancer cells. PLoS One. 10:e01315792015. View Article : Google Scholar : PubMed/NCBI

4 

Khrunin AV, Khokhrin DV, Moisseev AA, Gorbunova VA and Limborska SA: Pharmacogenomic assessment of cisplatin-based chemotherapy outcomes in ovarian cancer. Pharmacogenomics. 15:329–337. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Li J, Jiang K, Qiu X, Li M, Hao Q, Wei L, Zhang W, Chen B and Xin X: Overexpression of CXCR4 is significantly associated with cisplatin-based chemotherapy resistance and can be a prognostic factor in epithelial ovarian cancer. BMB Rep. 47:33–38. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Khrunin A, Ivanova F, Moisseev A, Khokhrin D, Sleptsova Y, Gorbunova V and Limborska S: Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins. Pharmacogenomics. 13:171–178. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Xu S, Fu GB, Tao Z, OuYang J, Kong F, Jiang BH, Wan X and Chen K: MiR-497 decreases cisplatin resistance in ovarian cancer cells by targeting mTOR/P70S6K1. Oncotarget. 6:26457–26471. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Spizzo R, Almeida MI, Colombatti A and Calin GA: Long non-coding RNAs and cancer: A new frontier of translational research? Oncogene. 31:4577–4587. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Tang J, Ahmad A and Sarkar FH: The role of MicroRNAs in breast cancer migration, invasion and metastasis. Int J Mol Sci. 13:13414–13437. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Takahashi K, Yan IK, Kogure T, Haga H and Patel T: Extracellular vesicle-mediated transfer of long non-coding RNA ROR modulates chemosensitivity in human hepatocellular cancer. FEBS Open Bio. 4:458–467. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Fan Y, Shen B, Tan M, Mu X, Qin Y, Zhang F and Liu Y: Long non-coding RNA UCA1 increases chemoresistance of bladder cancer cells by regulating Wnt signaling. FEBS J. 281:1750–1758. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Brun JL, Feyler A, Chêne G, Saurel J, Brun G and Hocké C: Long-term results and prognostic factor in patients with epithelial ovarian cancer. Gynecol Oncol. 78:21–27. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Chen J, Fu Z, Ji C, Gu P, Xu P, Yu N, Kan Y, Wu X, Shen R and Shen Y: Systematic gene microarray analysis of the lncRNA expression profiles in human uterine cervix carcinoma. Biomed Pharmacother. 72:83–90. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Lv M, Xu P, Wu Y, Huang L, Li W, Lv S, Wu X, Zeng X, Shen R, Jia X, et al: LncRNAs as new biomarkers to differentiate triple negative breast cancer from non-triple negative breast cancer. Oncotarget. 7:13047–13059. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Zhang X, Sun S, Pu JK, Tsang AC, Lee D, Man VO, Lui WM, Wong ST and Leung GK: Long non-coding RNA expression profiles predict clinical phenotypes in glioma. Neurobiol Dis. 48:1–8. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Spurlock CF III, Tossberg JT, Guo Y, Collier SP, Crooke PS III and Aune TM: Expression and functions of long noncoding RNAs during human T helper cell differentiation. Nat Commun. 6:69322015. View Article : Google Scholar : PubMed/NCBI

18 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in China, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Odening KE, Li W, Rutz R, Laufs S, Fruehauf S, Fishelson Z and Kirschfink M: Enhanced complement resistance in drug-selected P-glycoprotein expressing multi-drug-resistant ovarian carcinoma cells. Clin Exp Immunol. 155:239–248. 2009. View Article : Google Scholar : PubMed/NCBI

20 

O'Connor R, O'Leary M, Ballot J, Collins CD, Kinsella P, Mager DE, Arnold RD, O'Driscoll L, Larkin A, Kennedy S, et al: A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer. Cancer Chemother Pharmacol. 59:79–87. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Obata H, Yahata T, Quan J, Sekine M and Tanaka K: Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer. Anticancer Res. 26:2227–2232. 2006.PubMed/NCBI

22 

Scartozzi M, De Nictolis M, Galizia E, Carassai P, Bianchi F, Berardi R, Gesuita R, Piga A, Cellerino R and Porfiri E: Loss of hMLH1 expression correlates with improved survival in stage III–IV ovarian cancer patients. Eur J Cancer. 39:1144–1149. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Muenyi CS, States VA, Masters JH, Fan TW, Helm CW and States JC: Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC). J Ovarian Res. 4:92011. View Article : Google Scholar : PubMed/NCBI

24 

Metzinger DS, Taylor DD and Gercel-Taylor C: Induction of p53 and drug resistance following treatment with cisplatin or paclitaxel in ovarian cancer cell lines. Cancer Lett. 236:302–308. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Raspollini MR, Amunni G, Villanucci A, Castiglione F, Rossi Degl'Innocenti D, Baroni G, Paglierani M and Taddei GL: HER-2/neu and bcl-2 in ovarian carcinoma: Clinicopathologic, immunhistochemical and molecular study in patients with shorter and longer survival. Appl Immunohistochem Mol Morphol. 14:181–186. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Dao MD, Alwan LM, Gray HJ, Tamimi HK, Goff BA and Liao JB: Recurrence patterns after extended treatment with bevacizumab for ovarian, fallopian tube, and primary peritoneal cancers. Gynecol Oncol. 130:295–299. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Dhillon S: Bevacizumab combination therapy: A review of its use in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer. BioDrugs. 27:375–392. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Chen YA and Aravin AA: Non-coding RNAs in transcriptional regulation: The review for current molecular biology reports. Curr Mol Biol Rep. 1:10–18. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Rinn JL and Chang HY: Genome regulation by long noncoding RNAs. Annu Rev Biochem. 81:145–166. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Latos PA, Pauler FM, Koerner MV, Şenergin HB, Hudson QJ, Stocsits RR, Allhoff W, Stricker SH, Klement RM, Warczok KE, et al: Airn transcriptional overlap, but not its lncRNA products, induces imprinted Igf2r silencing. Science. 338:1469–1472. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Li H, Yu B, Li J, Su L, Yan M, Zhu Z and Liu B: Overexpression of lncRNA H19 enhances carcinogenesis and metastasis of gastric cancer. Oncotarget. 5:2318–2329. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Jin G, Sun J, Isaacs SD, Wiley KE, Kim ST, Chu LW, Zhang Z, Zhao H, Zheng SL, Isaacs WB and Xu J: Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. Carcinogenesis. 32:1655–1659. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Arase M, Horiguchi K, Ehata S, Morikawa M, Tsutsumi S, Aburatani H, Miyazono K and Koinuma D: Transforming growth factor-β-induced lncRNA-Smad7 inhibits apoptosis of mouse breast cancer JygMC(A) cells. Cancer Sci. 105:974–982. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Wang K, Long B, Zhou LY, Liu F, Zhou QY, Liu CY, Fan YY and Li PF: CARL lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing miR-539-dependent PHB2 downregulation. Nat Commun. 5:35962014.PubMed/NCBI

35 

Yang L, Lin C, Jin C, Yang JC, Tanasa B, Li W, Merkurjev D, Ohgi KA, Meng D, Zhang J, et al: lncrna-dependent mechanisms of androgen receptor-regulated gene activation programs. Nature. 500:598–602. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Wang K, Liu CY, Zhou LY, Wang JX, Wang M, Zhao B, Zhao WK, Xu SJ, Fan LH, Zhang XJ, et al: APF lncRNA regulates autophagy and myocardial infarction by targeting miR-188-3p. Nat Commun. 6:67792015. View Article : Google Scholar : PubMed/NCBI

37 

Shi SJ, Wang LJ, Yu B, Li YH, Jin Y and Bai XZ: LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer. Oncotarget. 6:11652–11663. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Shen X, Xie B, Ma Z, Yu W, Wang W, Xu D, Yan X, Chen B, Yu L, Li J, et al: Identification of novel long non-coding RNAs in triple-negative breast cancer. Oncotarget. 6:21730–21739. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Chen C, Li Z, Yang Y, Xiang T, Song W and Liu S: Microarray expression profiling of dysregulated long non-coding RNAs in triple-negative breast cancer. Cancer Biol Ther. 16:856–865. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Ponting CP, Oliver PL and Reik W: Evolution and functions of long noncoding RNAs. Cell. 136:629–641. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Necsulea A, Soumillon M, Warnefors M, Liechti A, Daish T, Zeller U, Baker JC, Grützner F and Kaessmann H: The evolution of lncRNA repertoires and expression patterns in tetrapods. Nature. 505:635–640. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Wang X, Chen Z, Mishra AK, Silva A, Ren W, Pan Z and Wang JH: Chemotherapy-induced differential cell cycle arrest in B cell lymphomas affects their sensitivity to Wee1 inhibition. Haematologica: Haematol. 2017:1759922017.

43 

Hajarnis SS, Patel V, Aboudehen K, Attanasio M, Cobo-Stark P, Pontoglio M and Igarashi P: Transcription factor hepatocyte nuclear factor-1β (HNF-1β) regulates MicroRNA-200 expression through a long Noncoding RNA. J Biol Chem. 290:24793–24805. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Cui W, Qian Y, Zhou X, Lin Y, Jiang J, Chen J, Zhao Z and Shen B: Discovery and characterization of long intergenic non-coding RNAs (lincRNA) module biomarkers in prostate cancer: An integrative analysis of RNA-Seq data. BMC Genomics. 16 Suppl 7:S32015. View Article : Google Scholar : PubMed/NCBI

45 

Hu Y, Wang J, Qian J, Kong X, Tang J, Wang Y, Chen H, Hong J, Zou W, Chen Y, et al: Long noncoding RNA GAPLINC regulates CD44-dependent cell invasiveness and associates with poor prognosis of gastric cancer. Cancer Res. 74:6890–6902. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Wu Y, Liu H, Shi X, Yao Y, Yang W and Song Y: The long non-coding RNA HNF1A-AS1 regulates proliferation and metastasis in lung adenocarcinoma. Oncotarget. 6:9160–9172. 2015.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Q, Zhang J, Zhou J, Yang B, Liu P, Cao L, Jing L and Liu H: lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer. Oncol Lett 15: 8363-8370, 2018.
APA
Li, Q., Zhang, J., Zhou, J., Yang, B., Liu, P., Cao, L. ... Liu, H. (2018). lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer. Oncology Letters, 15, 8363-8370. https://doi.org/10.3892/ol.2018.8433
MLA
Li, Q., Zhang, J., Zhou, J., Yang, B., Liu, P., Cao, L., Jing, L., Liu, H."lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer". Oncology Letters 15.6 (2018): 8363-8370.
Chicago
Li, Q., Zhang, J., Zhou, J., Yang, B., Liu, P., Cao, L., Jing, L., Liu, H."lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer". Oncology Letters 15, no. 6 (2018): 8363-8370. https://doi.org/10.3892/ol.2018.8433
Copy and paste a formatted citation
x
Spandidos Publications style
Li Q, Zhang J, Zhou J, Yang B, Liu P, Cao L, Jing L and Liu H: lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer. Oncol Lett 15: 8363-8370, 2018.
APA
Li, Q., Zhang, J., Zhou, J., Yang, B., Liu, P., Cao, L. ... Liu, H. (2018). lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer. Oncology Letters, 15, 8363-8370. https://doi.org/10.3892/ol.2018.8433
MLA
Li, Q., Zhang, J., Zhou, J., Yang, B., Liu, P., Cao, L., Jing, L., Liu, H."lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer". Oncology Letters 15.6 (2018): 8363-8370.
Chicago
Li, Q., Zhang, J., Zhou, J., Yang, B., Liu, P., Cao, L., Jing, L., Liu, H."lncRNAs are novel biomarkers for differentiating between cisplatin‑resistant and cisplatin‑sensitive ovarian cancer". Oncology Letters 15, no. 6 (2018): 8363-8370. https://doi.org/10.3892/ol.2018.8433
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