Miltirone‑induced apoptosis in cisplatin‑resistant lung cancer cells through upregulation of p53 signaling pathways

  • Authors:
    • Zhongcheng Zhu
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  • Published online on: April 5, 2018     https://doi.org/10.3892/ol.2018.8440
  • Pages: 8841-8846
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Abstract

The active ingredients of natural plants are important sources of antitumor agents. Miltirone is a major effective ingredient in traditional Chinese medicine and it is considered to have anti‑infection and immunosuppressive activities. Clinically, it is often used for the treatment of arthritis and immune diseases. The effect of miltirone on cisplatin‑resistant lung cancer cells has not been investigated to date. The present study aimed to examine the anticancer effect of miltirone in cisplatin‑resistant lung cancer cells. Treatment with miltirone suppressed cell viability and induced apoptosis in HCC827 and A549 platinum‑resistant lung cancer cells. It was also revealed that miltirone increased caspase‑3/8 activity as well as B‑cell lymphoma 2‑associated X‑protein, apoptosis‑inducing factor (AIF), p53 and poly(ADP‑ribose) polymerase (PARP) protein expression, whereas it inhibited mitochondrial reactive oxygen species (ROS) generation and matrix metalloproteinase (MMP)‑2/9 protein expression in HCC827 and A549 platinum‑resistant lung cancer cells. The results of the present study demonstrated that miltirone induces apoptosis in cisplatin‑resistant lung cancer cells through ROS‑p53, AIF, PARP and MMP2/9 signaling pathways.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhu Z: Miltirone‑induced apoptosis in cisplatin‑resistant lung cancer cells through upregulation of p53 signaling pathways. Oncol Lett 15: 8841-8846, 2018
APA
Zhu, Z. (2018). Miltirone‑induced apoptosis in cisplatin‑resistant lung cancer cells through upregulation of p53 signaling pathways. Oncology Letters, 15, 8841-8846. https://doi.org/10.3892/ol.2018.8440
MLA
Zhu, Z."Miltirone‑induced apoptosis in cisplatin‑resistant lung cancer cells through upregulation of p53 signaling pathways". Oncology Letters 15.6 (2018): 8841-8846.
Chicago
Zhu, Z."Miltirone‑induced apoptosis in cisplatin‑resistant lung cancer cells through upregulation of p53 signaling pathways". Oncology Letters 15, no. 6 (2018): 8841-8846. https://doi.org/10.3892/ol.2018.8440