CD57 ratio as a convenient and useful immunological and prognostic parameter for stage IV carcinoma
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- Published online on: April 10, 2018 https://doi.org/10.3892/ol.2018.8451
- Pages: 9257-9263
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Abstract
Cluster of differentiation (CD)8+CD57+ T cells are derived through the CD8+ T cell‑differentiation signaling pathway from early differentiated CD27+CD8+CD57‑T cells (early‑CD8+ T cells) to terminal‑differentiated CD27‑CD8+CD57+ T cells (terminal‑CD8+ T cells) via intermediate‑differentiated CD27+CD8+CD57+ T cells (intermediate‑CD8+ T cells). The increase of CD8+CD57+ T cells in the peripheral blood of patients with cancer has been associated with prognosis, which suggests their suitability as a candidate immunological marker. The present study investigated the association of these CD57‑related CD8+ T cell populations in the peripheral blood of 100 Stage IV cancer patients with progression‑free survival (PFS), using a Cox regression model. Univariate analysis indicated that early‑ and intermediate‑CD8+ T cells were associated with shorter PFS, whereas terminal‑CD8+ T cells were associated with longer PFS. A strong inverse correlation was observed between early‑ and terminal‑CD8+ T cells, and multivariate analysis demonstrated that the CD57 ratio (terminal‑CD8+ T cells/early‑CD8+ T cells) was a more significant independent prognostic factor compared with early‑ or terminal‑CD8+ T cells. Patients with a higher CD57 ratio had a significantly longer PFS compared with those with a lower CD57 ratio, in whom terminal‑CD8+ T cells were supposed to be predominant. Conversely, results indicated inhibition of the CD8+ T cell differentiation signaling pathway in patients with a low CD57 ratio, which lead to a predominance of early‑CD8+ T cells, a characteristic of immunosuppressive cells. The present findings suggested that the CD57 ratio appears to be a powerful immunological prognostic parameter obtained from the peripheral blood, precisely reflecting the state of CD8+ T cell‑differentiation.
