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Article

Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer

  • Authors:
    • Huan Wang
    • Xiao‑Ming Xing
    • Lei‑Na Ma
    • Lian Liu
    • Jing Hao
    • Ling‑Xin Feng
    • Zhuang Yu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266000, P.R. China, Department of Pathology, The Affiliated Hospital of Qingdao University; Qingdao, Shandong 266000, P.R. China, Department of Medical Oncology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
  • Pages: 8853-8862
    |
    Published online on: April 13, 2018
       https://doi.org/10.3892/ol.2018.8497
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Abstract

The long‑term prognosis for patients with gastric cancer (GC) following radical resection remains poor. It is important to identify prognostic markers to predict survival. In the present retrospective study, the association between the metastatic lymph node ratio (rN) and the Lauren classification on predicting overall survival (OS) was investigated. Furthermore, a subgroup analysis was performed on the Lauren classification, using rN score as an independent prognostic marker. In total, 261 pathologically confirmed patients with GC were retrospectively reviewed. Kaplan‑Meier curves and Cox's proportional hazards modeling were applied to analyze the OS of patients, and were utilized in the subgroup analysis. Receiver operating characteristic (ROC) curves were used to compare the accuracy of prognosis between the rN score and lymph node staging (N stage). The χ2 test was used to analyze the association between the rN score and Lauren classification. Univariate survival and multivariate analysis demonstrated that the rN score and Lauren classification were significant prognostic markers for patients with GC. The ROC analysis confirmed that the rN score was more effective than N staging for OS prediction. Subgroup analysis indicated that rN was more accurate at predicting OS time in patients with diffuse type GC. The rN score and the Lauren classification were independent prognostic factors for the OS of patients with GC following radical resection, and the rN score was more accurate than the N stage for predicting the prognosis. Overall, the rN may be suitable as an independent predictor for OS in patients with diffuse type GC.
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Copy and paste a formatted citation
Spandidos Publications style
Wang H, Xing XM, Ma LN, Liu L, Hao J, Feng LX and Yu Z: Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer. Oncol Lett 15: 8853-8862, 2018.
APA
Wang, H., Xing, X., Ma, L., Liu, L., Hao, J., Feng, L., & Yu, Z. (2018). Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer. Oncology Letters, 15, 8853-8862. https://doi.org/10.3892/ol.2018.8497
MLA
Wang, H., Xing, X., Ma, L., Liu, L., Hao, J., Feng, L., Yu, Z."Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer". Oncology Letters 15.6 (2018): 8853-8862.
Chicago
Wang, H., Xing, X., Ma, L., Liu, L., Hao, J., Feng, L., Yu, Z."Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer". Oncology Letters 15, no. 6 (2018): 8853-8862. https://doi.org/10.3892/ol.2018.8497
Copy and paste a formatted citation
x
Spandidos Publications style
Wang H, Xing XM, Ma LN, Liu L, Hao J, Feng LX and Yu Z: Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer. Oncol Lett 15: 8853-8862, 2018.
APA
Wang, H., Xing, X., Ma, L., Liu, L., Hao, J., Feng, L., & Yu, Z. (2018). Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer. Oncology Letters, 15, 8853-8862. https://doi.org/10.3892/ol.2018.8497
MLA
Wang, H., Xing, X., Ma, L., Liu, L., Hao, J., Feng, L., Yu, Z."Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer". Oncology Letters 15.6 (2018): 8853-8862.
Chicago
Wang, H., Xing, X., Ma, L., Liu, L., Hao, J., Feng, L., Yu, Z."Metastatic lymph node ratio and Lauren classification are independent prognostic markers for survival rates of patients with gastric cancer". Oncology Letters 15, no. 6 (2018): 8853-8862. https://doi.org/10.3892/ol.2018.8497
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