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Article Open Access

MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells

  • Authors:
    • Qinghua Huang
    • Qunying Ma
  • View Affiliations / Copyright

    Affiliations: Department of Breast Surgery, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China, Department of Gastroenterology, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 8941-8944
    |
    Published online on: April 17, 2018
       https://doi.org/10.3892/ol.2018.8516
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Abstract

MicroRNAs (miRNAs) regulate mammalian cell growth, differentiation and apoptosis by altering the expression of other genes, and serve multiple roles in tumorigenesis and progression. miR‑106a has been implicated in several types of malignancies. However, its role in colorectal cancer (CRC) remains unknown. The present study reported that in this particular cancer, miR‑106a exhibits a tumor suppressive role. It was demonstrated that the high expression of miR‑106a in CRC cells is negatively associated with E2F transcription factor 1 protein level and positively associated with caspase activation, suggesting a potential molecular switch.
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Copy and paste a formatted citation
Spandidos Publications style
Huang Q and Ma Q: MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells. Oncol Lett 15: 8941-8944, 2018.
APA
Huang, Q., & Ma, Q. (2018). MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells. Oncology Letters, 15, 8941-8944. https://doi.org/10.3892/ol.2018.8516
MLA
Huang, Q., Ma, Q."MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells". Oncology Letters 15.6 (2018): 8941-8944.
Chicago
Huang, Q., Ma, Q."MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells". Oncology Letters 15, no. 6 (2018): 8941-8944. https://doi.org/10.3892/ol.2018.8516
Copy and paste a formatted citation
x
Spandidos Publications style
Huang Q and Ma Q: MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells. Oncol Lett 15: 8941-8944, 2018.
APA
Huang, Q., & Ma, Q. (2018). MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells. Oncology Letters, 15, 8941-8944. https://doi.org/10.3892/ol.2018.8516
MLA
Huang, Q., Ma, Q."MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells". Oncology Letters 15.6 (2018): 8941-8944.
Chicago
Huang, Q., Ma, Q."MicroRNA‑106a inhibits cell proliferation and induces apoptosis in colorectal cancer cells". Oncology Letters 15, no. 6 (2018): 8941-8944. https://doi.org/10.3892/ol.2018.8516
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