Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance

  • Authors:
    • Yanping Liu
    • Han Sun
    • Hongju Mao
    • Meng Gao
    • Xiao Tan
    • Yue Li
    • Yan Li
    • Guy Mutangala Muloye
    • Lining Zhang
    • Xiaoyan Wang
    • Zengtao Wei
  • View Affiliations

  • Published online on: April 17, 2018     https://doi.org/10.3892/ol.2018.8517
  • Pages: 9369-9376
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Abstract

Programmed cell death 4 (PDCD4), as a novel tumor suppressor, serves important roles in the pathogenesis of tumors. The expression of PDCD4 is downregulated or lost in various human tumors. However, the expression of PDCD4 in endometrial cancer and the clinicopathological significance remain unclear. The aim of the present study was to investigate the expression of PDCD4 in endometrioid endometrial carcinoma (EEC) and the association with clinicopathological parameters. The expression of PDCD4 in EEC tissues and control endometrium was detected by reverse transcription‑quantitative polymerase chain reaction, western blotting and immunohistochemistry. PDCD4 expression was also investigated in control endometrial glandular epithelial cells and the endometrial cancer KLE cell line by immunocytochemistry, and the association between PDCD4 expression and clinicopathological parameters of patients with EEC was analyzed. The results demonstrated that PDCD4‑positive staining was mainly located in the cytoplasm of endometrial glandular epithelial cells and EEC cells. The staining index of PDCD4 in the proliferative phase was significantly increased compared with that in the secretory phase of control endometrium (P<0.001). There was significantly decreased PDCD4 expression in grade (G) 2/3 EEC tissues compared with the proliferative phase of control endometrium (P<0.001). PDCD4 expression was significantly associated with tumor grade. The PDCD4 levels in G1 EEC tissues were higher compared with the G2/3 EEC group (P<0.01). The results indicated that PDCD4 is associated with the histological grade of EEC, and that PDCD4 may be a valuable indicator of the degree of tumor malignancy in patients with EEC.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu Y, Sun H, Mao H, Gao M, Tan X, Li Y, Li Y, Muloye GM, Zhang L, Wang X, Wang X, et al: Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance. Oncol Lett 15: 9369-9376, 2018
APA
Liu, Y., Sun, H., Mao, H., Gao, M., Tan, X., Li, Y. ... Wei, Z. (2018). Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance. Oncology Letters, 15, 9369-9376. https://doi.org/10.3892/ol.2018.8517
MLA
Liu, Y., Sun, H., Mao, H., Gao, M., Tan, X., Li, Y., Li, Y., Muloye, G. M., Zhang, L., Wang, X., Wei, Z."Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance". Oncology Letters 15.6 (2018): 9369-9376.
Chicago
Liu, Y., Sun, H., Mao, H., Gao, M., Tan, X., Li, Y., Li, Y., Muloye, G. M., Zhang, L., Wang, X., Wei, Z."Expression of tumor suppressor programmed cell death 4 in endometrioid endometrial carcinomas and clinicopathological significance". Oncology Letters 15, no. 6 (2018): 9369-9376. https://doi.org/10.3892/ol.2018.8517