Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma

  • Authors:
    • Xuemei Du
    • Ying Gao
    • Hongyu Zhao
    • Bin Li
    • Weimin Xue
    • Daye Wang
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  • Published online on: April 18, 2018     https://doi.org/10.3892/ol.2018.8530
  • Pages: 9317-9326
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Abstract

Inflammatory myofibroblastic tumor (IMT) is a distinctive neoplasm composed of myofibroblastic and fibroblastic spindle cells, accompanied by the inflammatory infiltration of plasma cells, lymphocytes and/or eosinophils. Epithelioid inflammatory myofibroblastic sarcoma (EIMS), which primarily consists of cells with a round or epithelioid morphology, is associated with a poor prognosis and rapid development of local recurrence, and has been recognized to be a variant of IMT. Diagnosis of EIMS is difficult owing to its close resemblance to malignant mesothelioma, anaplastic large cell lymphoma, gastrointestinal stromal tumor and other malignant diseases. In the present study, a case of this rare tumor was evaluated in a 26‑year‑old male who was admitted to hospital after experiencing abdominal pain for ~18 days and abdominal distention for 1 week. The patient's tumor was examined by imaging, gross examination, histology, immunohistochemistry and fluorescence in situ hybridization (FISH). The magnetic resonance imaging enhanced‑scanning image revealed that the morphology of the tumor was irregular, and signal was medley consisting of high and low hybrid reinforcement. Tumors were located in the bladder and rectal pit, in the lower part of the lower abdomen, indicating the presence of malignancy and involvement of the small intestine and rectum. Enhanced‑scanning imaging revealed notable inhomogeneous enhancement. Gross examination revealed that the tumor was solid and had a variegated appearance with alternating fleshy and mucoid areas in the cut surface. Microscopically, the tumors were dominated by sheets of epithelioid‑to‑round cells with a prominent inflammatory infiltrate. The majority of the stroma was myxoid. Immunohistochemically, the tumor cells exhibited diffuse strong staining for ALK receptor tyrosine kinase (hereafter ALK), vimentin, tumor protein P53, desmin, Wilms' tumor 1 and programmed death‑ligand 1. FISH analysis also revealed the existence of ALK rearrangement. The expression of PD‑L1 in EIMS indicates that the immune checkpoint blockade could represent a novel therapy for the treatment of EIMS.
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June-2018
Volume 15 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Du X, Gao Y, Zhao H, Li B, Xue W and Wang D: Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma. Oncol Lett 15: 9317-9326, 2018
APA
Du, X., Gao, Y., Zhao, H., Li, B., Xue, W., & Wang, D. (2018). Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma. Oncology Letters, 15, 9317-9326. https://doi.org/10.3892/ol.2018.8530
MLA
Du, X., Gao, Y., Zhao, H., Li, B., Xue, W., Wang, D."Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma". Oncology Letters 15.6 (2018): 9317-9326.
Chicago
Du, X., Gao, Y., Zhao, H., Li, B., Xue, W., Wang, D."Clinicopathological analysis of epithelioid inflammatory myofibroblastic sarcoma". Oncology Letters 15, no. 6 (2018): 9317-9326. https://doi.org/10.3892/ol.2018.8530