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Article Open Access

MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation

  • Authors:
    • Liming Wu
    • Feibiao Yang
    • Bingyi Lin
    • Xinhua Chen
    • Shengyong Yin
    • Feng Zhang
    • Haiyang Xie
    • Lin Zhou
    • Shusen Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, P.R. China, Key Lab of Combined Multi‑Organ Transplantation, Ministry of Public Health, Ningbo, Zhejiang 315100, P.R. China, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Ningbo, Zhejiang 315100, P.R. China
    Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9126-9132
    |
    Published online on: April 19, 2018
       https://doi.org/10.3892/ol.2018.8539
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Abstract

MicroRNA‑424 (miR‑424) has previously been described as a biomarker of poor prognosis in patients with hepatocellular carcinoma (HCC). In the present study, the clinical significance of miR‑424 expression in predicting the rate of tumor recurrence in patients with HCC following liver transplantation (LT) was evaluated. miR‑424 expression in HCC samples from 121 patients undergoing LT was examined, and the associations between clinical parameters and patient tumor recurrence were evaluated. The miR‑424 expression level in cancer tissues was low compared with that in adjacent noncancerous tissues. Multivariate analyses revealed that low miR‑424 expression was an independent prognostic factor for tumor recurrence in patients with HCC following liver transplantation. Patients who no longer met the Milan criteria and had decreased miR‑424 expression levels exhibited earlier tumor recurrence following LT. In addition, the upregulation of miR‑424 expression significantly reduced the migration, invasion and proliferation of HCC cells. Similarly, the downregulation of miR‑424 in HCC cells significantly promoted the migration, invasion and proliferation of HCC cells.
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Copy and paste a formatted citation
Spandidos Publications style
Wu L, Yang F, Lin B, Chen X, Yin S, Zhang F, Xie H, Zhou L and Zheng S: MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation. Oncol Lett 15: 9126-9132, 2018.
APA
Wu, L., Yang, F., Lin, B., Chen, X., Yin, S., Zhang, F. ... Zheng, S. (2018). MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation. Oncology Letters, 15, 9126-9132. https://doi.org/10.3892/ol.2018.8539
MLA
Wu, L., Yang, F., Lin, B., Chen, X., Yin, S., Zhang, F., Xie, H., Zhou, L., Zheng, S."MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation". Oncology Letters 15.6 (2018): 9126-9132.
Chicago
Wu, L., Yang, F., Lin, B., Chen, X., Yin, S., Zhang, F., Xie, H., Zhou, L., Zheng, S."MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation". Oncology Letters 15, no. 6 (2018): 9126-9132. https://doi.org/10.3892/ol.2018.8539
Copy and paste a formatted citation
x
Spandidos Publications style
Wu L, Yang F, Lin B, Chen X, Yin S, Zhang F, Xie H, Zhou L and Zheng S: MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation. Oncol Lett 15: 9126-9132, 2018.
APA
Wu, L., Yang, F., Lin, B., Chen, X., Yin, S., Zhang, F. ... Zheng, S. (2018). MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation. Oncology Letters, 15, 9126-9132. https://doi.org/10.3892/ol.2018.8539
MLA
Wu, L., Yang, F., Lin, B., Chen, X., Yin, S., Zhang, F., Xie, H., Zhou, L., Zheng, S."MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation". Oncology Letters 15.6 (2018): 9126-9132.
Chicago
Wu, L., Yang, F., Lin, B., Chen, X., Yin, S., Zhang, F., Xie, H., Zhou, L., Zheng, S."MicroRNA‑424 expression predicts tumor recurrence in patients with hepatocellular carcinoma following liver transplantation". Oncology Letters 15, no. 6 (2018): 9126-9132. https://doi.org/10.3892/ol.2018.8539
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