Long non‑coding RNA ZNF674‑1 acts as a cancer suppressor in nasopharyngeal carcinoma

Nie,Guo‑Hui; Li,Zhao; Duan,Hong‑Fang; Luo,Liang; Hu,Hong‑Yi; Chen,Xiao‑Fan; Zhang,Wei

doi:10.3892/ol.2018.8540

Long non‑coding RNA ZNF674‑1 acts as a cancer suppressor in nasopharyngeal carcinoma

Authors:
- Guo‑Hui Nie
- Zhao Li
- Hong‑Fang Duan
- Liang Luo
- Hong‑Yi Hu
- Xiao‑Fan Chen
- Wei Zhang
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Affiliations: Department of Otolaryngology, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China , Department of Otolaryngology, The Third People's Hospital of Chengdu, Chengdu, Sichuan 610031, P.R. China, Department of Otolaryngology, Shenzhen Children's Hospital, Shenzhen, Guangdong 518038, P.R. China, Department of Otolaryngology, Ganzhou City People's Hospital, Ganzhou, Jiangxi 342300, P.R. China, Department of Otolaryngology, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518036, P.R. China, Biomedical Research Institute, Shenzhen Peking University, Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong 518036, P.R. China
Published online on: April 19, 2018 https://doi.org/10.3892/ol.2018.8540
Pages: 10047-10054

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Abstract

Nasopharyngeal carcinoma (NPC) is the most frequently occurring carcinoma of the head and neck. The complexity of NPC makes it difficult for it to be diagnosed and treated at an early stage. Certain long non‑coding RNAs (lncRNAs) are closely associated with the carcinogenesis of NPC. In the present study, the expression of lncRNA ZNF674‑1 in NPC tissues and an NPC cell line was analyzed and was revealed to be downregulated compared with normal tissues and cells. When the expression of lncRNA ZNF674‑1 was reduced in NPC cells, the proliferation, migration and invasion of these cells was promoted, whereas the apoptosis of these cells was decreased. On the contrary, when overexpressed, the expression of lncRNA ZNF674‑1 inhibited the proliferation, invasion and migration of cells, but promoted cell apoptosis. The results of the present study reveal that the lncRNA ZNF67‑1 may restrain the carcinogenesis of NPC, and may also serve as a potential biomarker for the early diagnosis and treatment of NPC.

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