Multi‑modality imaging features distinguish pancreatic carcinoma from mass‑forming chronic pancreatitis of the pancreatic head

Ruan,Zhibing; Jiao,Jun; Min,Dingyu; Qu,Jinhuan; Li,Jing; Chen,Jing; Li,Qi; Wang,Chunhong

doi:10.3892/ol.2018.8545

Multi‑modality imaging features distinguish pancreatic carcinoma from mass‑forming chronic pancreatitis of the pancreatic head

Authors:
- Zhibing Ruan
- Jun Jiao
- Dingyu Min
- Jinhuan Qu
- Jing Li
- Jing Chen
- Qi Li
- Chunhong Wang
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Affiliations: Department of Radiology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China, Department of Medical Records and Statistics, Guizhou Provincial People's Hospital, Guiyang, Guizhou 550002, P.R. China
Published online on: April 20, 2018 https://doi.org/10.3892/ol.2018.8545
Pages: 9735-9744
Copyright: © Ruan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study retrospectively analyzed computerized tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography‑computerized tomography (PET/CT) data to identify features that may distinguish pancreatic carcinoma (PC) from mass‑forming chronic pancreatitis (MFCP) of the pancreatic head. The mean diameter of the lesions was larger in the MFCP patients (n=24) than in the PC patients (n=30; 5.44±27 vs. 3.34±1.23 cm; P<0.001). PC lesions showed increased lobulation when compared with the MFCP cases (83.33 vs. 12.5%; P<0.001). Lesions in the MFCP patients exhibited diffuse and marginally distributed calcification. MFCP patients showed increased exudation around the lesion (83.33 vs. 13.33%), pseudocyst formation (58.33 vs. 10%) and thickening of the right renal fascia (83.33 vs. 13.33%) than in the PC patients. MFCP patients also exhibited visible remnants of normal pancreatic tissue within the lesions. MFCP and PC patients could be distinguished by a cutoff value of 4.40 cm for lesion size [area under the curve (AUC): 0.894; 95% confidence interval (CI): 0.810‑0.978)], 21.85 Hu for net‑increased value in the arterial phase (AUC, 0.799; 95% CI, 0.670‑0.928), 37.70 Hu for net‑increased value in the portal phase (AUC, 0.798; 95% CI, 0.919‑0.677), 4.85 for early standardized uptake value (SUV) of 18F‑deoxyglucose (18F‑FDG; AUC, 0.934; 95% CI, 0.850‑1.018) and 4.90 for delayed SUV of 18F‑FDG (AUC, 0.958; 95% CI, 0.878‑1.038). These findings demonstrated that the integration of data from dynamic contrast‑enhanced CT, MRI and PET/CT imaging may distinguish MFCP from PC.

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