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Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods

  • Authors:
    • Lu Zhang
    • Cuihua Feng
    • Yamin Zhou
    • Qiong Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Wuhan No. 6 Hospital, Wuhan, Hubei 430015, P.R. China, Department of Gastrointestinal Surgery, Wuhan No. 6 Hospital, Wuhan, Hubei 430015, P.R. China, Intensive Care Unit, Wuhan No. 6 Hospital, Wuhan, Hubei 430015, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 9617-9624
    |
    Published online on: April 27, 2018
       https://doi.org/10.3892/ol.2018.8602
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Abstract

The present study aimed to identify bladder cancer‑associated microRNAs (miRNAs) and target genes, and further analyze the potential molecular mechanisms involved in bladder cancer. The mRNA and miRNA expression profiling dataset GSE40355 was downloaded from the Gene Expression Omnibus database. The Limma package in R was used to identify differential expression levels. The Human microRNA Disease Database was used to identify bladder cancer‑associated miRNAs and Target prediction programs were used to screen for miRNA target genes. Enrichment analysis was performed to identify biological functions. The Database for Annotation, Visualization and Integration Discovery was used to perform OMIM_DISEASE analysis, and then protein‑protein interaction (PPI) analysis was performed to identify hubs with biological essentiality. ClusterONE plugins in cytoscape were used to screen modules and the InterPro database was used to perform protein domain enrichment analysis. A group of 573 disease dysregulated genes were identified in the present study. Enrichment analysis indicated that the muscle organ development and vascular smooth muscle contraction pathways were significantly enriched in terms of disease dysregulated genes. miRNAs targets (frizzled class receptor 8, EYA transcriptional coactivator and phosphatase 4, sacsin molecular chaperone, calcium voltage‑gated channel auxiliary subunit β2, peptidase inhibitor 15 and catenin α2) were mostly associated with bladder cancer. PPI analysis revealed that calmodulin 1 (CALM1), Jun proto‑oncogene, AP‑1 transcription factor subunit (JUN) and insulin like growth factor 1 (IGF1) were the important hub nodes. Additionally, protein domain enrichment analysis indicated that the serine/threonine protein kinase active site was enriched in module 1 extracted from the PPI network. Overall, the results suggested that the IGF signaling pathway and RAS/MEK/extracellular signal‑regulated kinase transduction signaling may exert vital molecular mechanisms in bladder cancer, and that CALM1, JUN and IGF1 may be used as novel potential therapeutic targets.
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1 

Fangliu G and Yuli L: Changing status of genitourinary cancer in recent 50 years. Chin J Urol. 2:88–90. 2002.

2 

Gaston KE and Grossman HB: Proteomic assays for the detection of urothelial cancer. Methods Mol Biol. 641:303–323. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Dyrskjøt L, Ostenfeld MS, Bramsen JB, Silahtaroglu AN, Lamy P, Ramanathan R, Fristrup N, Jensen JL, Andersen CL, Zieger K, et al: Genomic profiling of microRNAs in bladder cancer: miR-129 is associated with poor outcome and promotes cell death in vitro. Cancer Res. 69:4851–4860. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Dyrskjot L, Zieger K and Orntoft TF: Recent advances in high-throughput molecular marker identification for superficial and invasive bladder cancers. Front Biosci. 12:2063–2073. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Fendler A, Stephan C, Yousef GM and Jung K: MicroRNAs as regulators of signal transduction in urological tumors. Clin Chem. 57:954–968. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Wu W, Sun M, Zou GM and Chen J: MicroRNA and cancer: Current status and prospective. Int J Cancer. 120:953–960. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Li X, Chen J, Hu X, Huang Y, Li Z, Zhou L, Tian Z, Ma H, Wu Z, Chen M, et al: Comparative mRNA and microRNA expression profiling of three genitourinary cancers reveals common hallmarks and cancer-specific molecular events. PLoS One. 6:e225702011. View Article : Google Scholar : PubMed/NCBI

8 

Guo AY, Sun J, Jia P and Zhao Z: A novel microRNA and transcription factor mediated regulatory network in schizophrenia. BMC Syst Biol. 4:102010. View Article : Google Scholar : PubMed/NCBI

9 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Ambros V: The functions of animal microRNAs. Nature. 431:350–355. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Gottardo F, Liu CG, Ferracin M, Calin GA, Fassan M, Bassi P, Sevignani C, Byrne D, Negrini M, Pagano F, et al: Micro-RNA profiling in kidney and bladder cancers. Urol Oncol. 25:387–392. 2007. View Article : Google Scholar : PubMed/NCBI

12 

da Huang W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

14 

Harris MA, Clark J, Ireland A, Lomax J, Ashburner M, Foulger R, Eilbeck K, Lewis S, Marshall B, Mungall C, et al: The gene ontology (GO) database and informatics resource. Nucleic Acids Res. 32:(Database Issue). D258–D261. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Kar G, Gursoy A and Keskin O: Human cancer protein-protein interaction network: A structural perspective. PLoS Comput Biol. 5:e10006012009. View Article : Google Scholar : PubMed/NCBI

16 

Song J and Singh M: How and when should interactome-derived clusters be used to predict functional modules and protein function? Bioinformatics. 25:3143–3150. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Jia P, Kao CF, Kuo PH and Zhao Z: A comprehensive network and pathway analysis of candidate genes in major depressive disorder. BMC Syst Biol. 5 Suppl 3:S122011. View Article : Google Scholar : PubMed/NCBI

18 

Hecker N, Stephan C, Mollenkopf HJ, Jung K, Preissner R and Meyer HA: A new algorithm for integrated analysis of miRNA-mRNA interactions based on individual classification reveals insights into bladder cancer. PLoS One. 8:e645432013. View Article : Google Scholar : PubMed/NCBI

19 

Efron B and Tibshirani R: Empirical bayes methods and false discovery rates for microarrays. Genet Epidemiol. 23:70–86. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Polpitiya AD, Qian WJ, Jaitly N, Petyuk VA, Adkins JN, Camp DG II, Anderson GA and Smith RD: DAnTE: A statistical tool for quantitative analysis of -omics data. Bioinformatics. 24:1556–1558. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Saito R, Smoot ME, Ono K, Ruscheinski J, Wang PL, Lotia S, Pico AR, Bader GD and Ideker T: A travel guide to Cytoscape plugins. Nat Methods. 9:1069–1076. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Xiao F, Zuo Z, Cai G, Kang S, Gao X and Li T: miRecords: An integrated resource for microRNA-target interactions. Nucleic Acids Res. 37:(Database Issue). D105–D110. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C and Jensen LJ: STRING v9. 1: Protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res. 4137:(Database Issue). D808–D815. 2013.

24 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

25 

Apweiler R, Attwood TK, Bairoch A, Bateman A, Birney E, Biswas M, Bucher P, Cerutti L, Corpet F, Croning MD, et al: The InterPro database, an integrated documentation resource for protein families, domains and functional sites. Nucleic Acids Res. 29:37–40. 2001. View Article : Google Scholar : PubMed/NCBI

26 

Filipowicz W, Bhattacharyya SN and Sonenberg N: Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nat Rev Genet. 9:102–114. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Itesako T, Seki N, Yoshino H, Chiyomaru T, Yamasaki T, Hidaka H, Yonezawa T, Nohata N, Kinoshita T, Nakagawa M and Enokida H: The MicroRNA expression signature of bladder cancer by deep sequencing: The functional significance of the miR-195/497 cluster. PLoS One. 9:e843112014. View Article : Google Scholar : PubMed/NCBI

28 

Han Y, Chen J, Zhao X, Liang C, Wang Y, Sun L, Jiang Z, Zhang Z, Yang R, Chen J, et al: MicroRNA expression signatures of bladder cancer revealed by deep sequencing. PLoS One. 6:e182862011. View Article : Google Scholar : PubMed/NCBI

29 

McConkey DJ, Lee S, Choi W, Tran M, Majewski T, Lee S, Siefker-Radtke A, Dinney C and Czerniak B: Molecular genetics of bladder cancer: Emerging mechanisms of tumor initiation and progression. Urol Oncol. 28:429–440. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Ueno K, Hirata H, Hinoda Y and Dahiya R: Frizzled homolog proteins, microRNAs and Wnt signaling in cancer. Int J Cancer. 132:1731–1740. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Zou H, Osborn NK, Harrington JJ, Klatt KK, Molina JR, Burgart LJ and Ahlquist DA: Frequent methylation of eyes absent 4 gene in Barrett's esophagus and esophageal adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 14:830–834. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Gibbs GM, Roelants K and O'Bryan MK: The CAP superfamily: Cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins-roles in reproduction, cancer, and immune defense. Endocr Rev. 29:865–897. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Fanjul-Fernández M, Quesada V, Cabanillas R, Cadiñanos J, Fontanil T, Obaya A, Ramsay AJ, Llorente JL, Astudillo A, Cal S and López-Otín C: Cell-cell adhesion genes CTNNA2 and CTNNA3 are tumour suppressors frequently mutated in laryngeal carcinomas. Nat Commun. 4:25312013. View Article : Google Scholar : PubMed/NCBI

34 

Rai A, Menon AV and Jalan S: Randomness and preserved patterns in cancer network. Sci Rep. 4:63682014. View Article : Google Scholar : PubMed/NCBI

35 

He X and Zhang J: Why do hubs tend to be essential in protein networks? PLoS Genet. 2:e882006. View Article : Google Scholar : PubMed/NCBI

36 

Tognon CE and Sorensen PH: Targeting the insulin-like growth factor 1 receptor (IGF1R) signaling pathway for cancer therapy. Expert Opin Ther Targets. 16:33–48. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Tsai TF, Lin YC, Chen HE, Chou KY, Lin JF and Hwang TI: Involvement of the insulin-like growth factor I receptor and its downstream antiapoptotic signaling pathway is revealed by dysregulated microRNAs in bladder carcinoma. Urological Sci. 25:58–54. 2014. View Article : Google Scholar

38 

Puzio-Kuter AM, Castillo-Martin M, Kinkade CW, Wang X, Shen TH, Matos T, Shen MM, Cordon-Cardo C and Abate-Shen C: Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 23:675–680. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Berchtold MW and Villalobo A: The many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer. Biochim Biophys Acta. 1843:398–435. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Lopez-Bergami P, Lau E and Ronai Z: Emerging roles of ATF2 and the dynamic AP1 network in cancer. Nat Rev Cancer. 10:65–76. 2010. View Article : Google Scholar : PubMed/NCBI

41 

Manning G, Whyte DB, Martinez R, Hunter T and Sudarsanam S: The protein kinase complement of the human genome. Science. 298:1912–1934. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Roskoski R Jr: RAF protein-serine/threonine kinases: Structure and regulation. Biochem Biophys Res Commun. 399:313–317. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Zebisch A and Troppmair J: Back to the roots: The remarkable RAF oncogene story. Cell Mol Life Sci. 63:1314–1330. 2006. View Article : Google Scholar : PubMed/NCBI

44 

Brault L, Gasser C, Bracher F, Huber K, Knapp S and Schwaller J: PIM serine/threonine kinases in the pathogenesis and therapy of hematologic malignancies and solid cancers. Haematologica. 95:1004–1015. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Roberts PJ and Der CJ: Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene. 26:3291–3310. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Tao HC, Wang HX, Dai M, Gu CY, Wang Q, Han ZG and Cai B: Targeting SHCBP1 inhibits cell proliferation in human hepatocellular carcinoma cells. Asian Pac J Cancer Prev. 14:5645–5650. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang L, Feng C, Zhou Y and Zhou Q: Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods. Oncol Lett 15: 9617-9624, 2018.
APA
Zhang, L., Feng, C., Zhou, Y., & Zhou, Q. (2018). Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods. Oncology Letters, 15, 9617-9624. https://doi.org/10.3892/ol.2018.8602
MLA
Zhang, L., Feng, C., Zhou, Y., Zhou, Q."Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods". Oncology Letters 15.6 (2018): 9617-9624.
Chicago
Zhang, L., Feng, C., Zhou, Y., Zhou, Q."Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods". Oncology Letters 15, no. 6 (2018): 9617-9624. https://doi.org/10.3892/ol.2018.8602
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang L, Feng C, Zhou Y and Zhou Q: Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods. Oncol Lett 15: 9617-9624, 2018.
APA
Zhang, L., Feng, C., Zhou, Y., & Zhou, Q. (2018). Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods. Oncology Letters, 15, 9617-9624. https://doi.org/10.3892/ol.2018.8602
MLA
Zhang, L., Feng, C., Zhou, Y., Zhou, Q."Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods". Oncology Letters 15.6 (2018): 9617-9624.
Chicago
Zhang, L., Feng, C., Zhou, Y., Zhou, Q."Dysregulated genes targeted by microRNAs and metabolic pathways in bladder cancer revealed by bioinformatics methods". Oncology Letters 15, no. 6 (2018): 9617-9624. https://doi.org/10.3892/ol.2018.8602
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