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Article

MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells

  • Authors:
    • Bing Guan
    • Lijun Mu
    • Linlin Zhang
    • Ke Wang
    • Juanhua Tian
    • Shan Xu
    • Xinyang Wang
    • Dalin He
    • Yuefeng Du
  • View Affiliations / Copyright

    Affiliations: Department of Urology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China
  • Pages: 1821-1826
    |
    Published online on: June 1, 2018
       https://doi.org/10.3892/ol.2018.8877
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Abstract

MicroRNA (miRNA) is a class of non‑coding single‑stranded RNA, able to regulate tumor‑associated genes via binding the 3'‑UTR of the target gene mRNA. Previous publications have demonstrated that miRNA‑218 (miR‑218) acts as a tumor‑suppressive miRNA in various types of human cancer, including prostate cancer (PCa). However, the role of miR‑218 in regulating PCa cell stemness and epithelial‑mesenchymal transition remains unknown and requires further research. In the present study, it is demonstrated that miR‑218 was downregulated in 2 PCa cell lines and could suppress cell migration, EMT and the exhibition of cancer stem cell‑like properties. The expression of GLI family zinc finger 1 (Gli1) was inhibited by miR‑218 overexpression, suggesting miR‑218‑suppression of Gli1 as a potential mechanism for the tumor‑suppressive effect of miR‑218. Overall, the results indicate that miR‑218 served a critical role in the inhibition of PCa development. This may provide new insight for elucidating the mechanisms of PCa oncogenesis and suggests that miR‑218 may be a novel therapeutic target for PCa.
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Copy and paste a formatted citation
Spandidos Publications style
Guan B, Mu L, Zhang L, Wang K, Tian J, Xu S, Wang X, He D and Du Y: MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells. Oncol Lett 16: 1821-1826, 2018.
APA
Guan, B., Mu, L., Zhang, L., Wang, K., Tian, J., Xu, S. ... Du, Y. (2018). MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells. Oncology Letters, 16, 1821-1826. https://doi.org/10.3892/ol.2018.8877
MLA
Guan, B., Mu, L., Zhang, L., Wang, K., Tian, J., Xu, S., Wang, X., He, D., Du, Y."MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells". Oncology Letters 16.2 (2018): 1821-1826.
Chicago
Guan, B., Mu, L., Zhang, L., Wang, K., Tian, J., Xu, S., Wang, X., He, D., Du, Y."MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells". Oncology Letters 16, no. 2 (2018): 1821-1826. https://doi.org/10.3892/ol.2018.8877
Copy and paste a formatted citation
x
Spandidos Publications style
Guan B, Mu L, Zhang L, Wang K, Tian J, Xu S, Wang X, He D and Du Y: MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells. Oncol Lett 16: 1821-1826, 2018.
APA
Guan, B., Mu, L., Zhang, L., Wang, K., Tian, J., Xu, S. ... Du, Y. (2018). MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells. Oncology Letters, 16, 1821-1826. https://doi.org/10.3892/ol.2018.8877
MLA
Guan, B., Mu, L., Zhang, L., Wang, K., Tian, J., Xu, S., Wang, X., He, D., Du, Y."MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells". Oncology Letters 16.2 (2018): 1821-1826.
Chicago
Guan, B., Mu, L., Zhang, L., Wang, K., Tian, J., Xu, S., Wang, X., He, D., Du, Y."MicroRNA‑218 inhibits the migration, epithelial‑mesenchymal transition and cancer stem cell properties of prostate cancer cells". Oncology Letters 16, no. 2 (2018): 1821-1826. https://doi.org/10.3892/ol.2018.8877
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