Open Access

miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer

  • Authors:
    • Xuefeng Jiang
    • Zhe Wang
  • View Affiliations

  • Published online on: June 20, 2018     https://doi.org/10.3892/ol.2018.8997
  • Pages: 3005-3012
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Abstract

There is increasing evidence that microRNAs (miRNAs) play important roles in tumor progression and development by targeting different genes, including gastric cancer (GC). However, the role of miR-16 in GC is so far unclear. Herein, we examined the function and potential mechanism of miR-16 in GC. Reverse transcription-quantitative PCR found that miR-16 expression was prominently lower in GC tissues while SALL4 expression was frequently higher than normal tissues. Re-expression of miR-16 could suppress GC cell proliferation and migration by MTT and Transwell assay. We confirmed that miR-16 directly targeted SALL4 in regulating GC by luciferase assay. Knockdown of SALL4 inhibited cell proliferation and migration. Furthermore, SALL4 could counteract the inhibition-effect of miR-16 in GC. In conclusion, for the the first time we demonstrated that miR-16 played inhibitory effect through targeting SALL4 in GC cell proliferation and migration. Our study revealed that miR-16/SALL4 axis was critical in regulating the GC development, indicating a new prospect to regulate GC cell progression and development.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jiang X and Wang Z: miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer. Oncol Lett 16: 3005-3012, 2018.
APA
Jiang, X., & Wang, Z. (2018). miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer. Oncology Letters, 16, 3005-3012. https://doi.org/10.3892/ol.2018.8997
MLA
Jiang, X., Wang, Z."miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer". Oncology Letters 16.3 (2018): 3005-3012.
Chicago
Jiang, X., Wang, Z."miR-16 targets SALL4 to repress the proliferation and migration of gastric cancer". Oncology Letters 16, no. 3 (2018): 3005-3012. https://doi.org/10.3892/ol.2018.8997