Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure

  • Authors:
    • Sung‑Jae Baek
    • Katsutoshi Sato
    • Naohiro Nishida
    • Jun Koseki
    • Kazuhiko Hayashi
    • Koichi Kawamoto
    • Masamitsu Konno
    • Yuichiro Doki
    • Masaki Mori
    • Kazuhiko Ogawa
    • Hideshi Ishii
  • View Affiliations

  • Published online on: June 21, 2018     https://doi.org/10.3892/ol.2018.9004
  • Pages: 3389-3393
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Abstract

Although charged particle therapy, including carbon ion beam radiation, is a cutting‑edge technology in human cancer treatment, the molecular mechanisms underlying cellular resistance to this type of therapy remain unknown. Furthermore, the chemotherapeutic agents that are most effective at overcoming cellular resistance remain unknown. In the present study, carbon ion beam radioresistant rodent cells were developed and their sensitization to trifluorothymidine (FTD), a derivative of deoxythymidine, was studied. The results of the present study demonstrated that carbon ion beam radioresistant cells were more sensitive to FTD compared with X‑ray radioresistant cells. The results of the present study suggested that FTD is involved in carbon ion beam radioresistance, encouraging further study of cellular resistance to charged particle therapy for refractory human cancer.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Baek SJ, Sato K, Nishida N, Koseki J, Hayashi K, Kawamoto K, Konno M, Doki Y, Mori M, Ogawa K, Ogawa K, et al: Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure. Oncol Lett 16: 3389-3393, 2018
APA
Baek, S., Sato, K., Nishida, N., Koseki, J., Hayashi, K., Kawamoto, K. ... Ishii, H. (2018). Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure. Oncology Letters, 16, 3389-3393. https://doi.org/10.3892/ol.2018.9004
MLA
Baek, S., Sato, K., Nishida, N., Koseki, J., Hayashi, K., Kawamoto, K., Konno, M., Doki, Y., Mori, M., Ogawa, K., Ishii, H."Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure". Oncology Letters 16.3 (2018): 3389-3393.
Chicago
Baek, S., Sato, K., Nishida, N., Koseki, J., Hayashi, K., Kawamoto, K., Konno, M., Doki, Y., Mori, M., Ogawa, K., Ishii, H."Carbon ion beam radioresistant rodent cells are sensitized to trifluorothymidine exposure". Oncology Letters 16, no. 3 (2018): 3389-3393. https://doi.org/10.3892/ol.2018.9004