|
1
|
Ohsawa I, Ishikawa M, Takahashi K,
Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S
and Ohta S: Hydrogen acts as a therapeutic antioxidant by
selectively reducing cytotoxic oxygen radicals. Nat Med.
13:688–694. 2007. View
Article : Google Scholar : PubMed/NCBI
|
|
2
|
Sato Y, Kajiyama S, Amano A, Kondo Y,
Sasaki T, Handa S, Takahashi R, Fukui M, Hasegawa G, Nakamura N, et
al: Hydrogen-rich pure water prevents superoxide formation in brain
slices of vitamin C-depleted SMP30/GNL knockout mice. Biochem
Biophys Res Commun. 375:346–350. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Rojas V, Hirshfield KM, Ganesan S and
Rodriguez-Rodriguez L: Molecular characterization of epithelial
ovarian cancer: Implications for diagnosis and treatment. Int J Mol
Sci. 17:pii: E2113. 2016. View Article : Google Scholar
|
|
4
|
Nakashima-Kamimura N, Mori T, Ohsawa I,
Asoh S and Ohta S: Molecular hydrogen alleviates nephrotoxicity
induced by an anti-cancer drug cisplatin without compromising
anti-tumor activity in mice. Cancer Chemother Pharmacol.
64:753–761. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
James AM, Cochemé HM and Murphy MP:
Mitochondria-targeted redox probes as tools in the study of
oxidative damage and ageing. Mech Ageing Dev. 126:982–986. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Cardinal JS, Zhan J, Wang Y, Sugimoto R,
Tsung A, McCurry KR, Billiar TR and Nakao A: Oral hydrogen water
prevents chronic allograft nephropathy in rats. Kidney Int.
77:101–109. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Nakao A, Toyoda Y, Sharma P, Evans M and
Guthrie N: Effectiveness of hydrogen rich water on antioxidant
status of subjects with potential metabolic syndrome-an open label
pilot study. J Clin Biochem Nutr. 46:140–149. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Zheng X, Mao Y, Cai J, Li Y, Liu W, Sun P,
Zhang JH, Sun X and Yuan H: Hydrogen-rich saline protects against
intestinal ischemia/reperfusion injury in rats. Free Radic Res.
43:478–484. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Nagatani K, Nawashiro H, Takeuchi S,
Tomura S, Otani N, Osada H, Wada K, Katoh H, Tsuzuki N and Mori K:
Safety of intravenous administration of hydrogen-enriched fluid in
patients with acute cerebral ischemia: Initial clinical studies.
Med Gas Res. 3:132013. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Ono H, Nishijima Y, Adachi N, Sakamoto M,
Kudo Y, Nakazawa J, Kaneko K and Nakao A: Hydrogen(H2) treatment
for acute erythymatous skin diseases. A report of 4 patients with
safety data and a non-controlled feasibility study with H2
concentration measurement on two volunteers. Med Gas Res. 2:142012.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Zhu Q, Wu Y, Li Y, Chen Z, Wang L, Xiong
H, Dai E, Wu J, Fan B, Ping L and Luo X: Positive effects of
hydrogen-water bathing in patients of psoriasis and parapsoriasis
en plaques. Sci Rep. 8:80512018. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Kubota M, Shimmura S, Kubota S, Miyashita
H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, et al:
Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced
angiogenesis in a mouse corneal alkali-burn model. Invest
Ophthalmol Vis Sci. 52:427–433. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Oharazawa H, Igarashi T, Yokota T, Fujii
H, Suzuki H, Machide M, Takahashi H, Ohta S and Ohsawa I:
Protection of the retina by rapid diffusion of hydrogen:
Administration of hydrogen-loaded eye drops in retinal
ischemia-reperfusion injury. Invest Ophthalmol Vis Sci. 51:487–492.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ames BN and Gold LS: Animal cancer tests
and cancer prevention. J Natl Cancer Inst Monogr. 125–132.
1992.PubMed/NCBI
|
|
15
|
Guyton KZ and Kensler TW: Oxidative
mechanisms in carcinogenesis. Br Med Bull. 49:523–544. 1993.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Schulte-Hermann R, Timmermann-Trosiener I,
Barthel G and Bursch W: DNA synthesis, apoptosis, and phenotypic
expression as determinants of growth of altered foci in rat liver
during phenobarbital promotion. Cancer Res. 50:5127–5135.
1990.PubMed/NCBI
|
|
17
|
Trush MA and Kensler TW: An overview of
the relationship between oxidative stress and chemical
carcinogenesis. Free Radic Biol Med. 10:201–209. 1991. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Cerutti PA: Prooxidant states and tumor
promotion. Science. 227:375–381. 1985. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Duracková Z: Some current insights into
oxidative stress. Physiol Res. 59:459–469. 2010.PubMed/NCBI
|
|
20
|
Zhang G, Miura Y and Yagasaki K:
Suppression of adhesion and invasion of hepatoma cells in culture
by tea compounds through antioxidative activity. Cancer Lett.
159:169–173. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Fridovich I: The biology of oxygen
radicals. Science. 201:875–880. 1978. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Hussain SP, Hofseth LJ and Harris CC:
Radical causes of cancer. Nat Rev Cancer. 3:276–285. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Lei XG, Zhu JH, Cheng WH, Bao Y, Ho YS,
Reddi AR, Holmgren A and Arnér ES: Paradoxical roles of antioxidant
enzymes: Basic mechanisms and health implications. Physiol Rev.
96:307–364. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Szatrowski TP and Nathan CF: Production of
large amounts of hydrogen peroxide by human tumor cells. Cancer
Res. 51:794–798. 1991.PubMed/NCBI
|
|
25
|
Miyajima A, Nakashima J, Yoshioka K,
Tachibana M, Tazaki H and Murai M: Role of reactive oxygen species
in cis-dichlorodiammineplatinum-induced cytotoxicity on bladder
cancer cells. Br J Cancer. 76:206–210. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Salganik RI, Albright CD, Rodgers J, Kim
J, Zeisel SH, Sivashinskiy MS and Van Dyke TA: Dietary antioxidant
depletion: Enhancement of tumor apoptosis and inhibition of brain
tumor growth in transgenic mice. Carcinogenesis. 21:909–914. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Brown NS and Bicknell R: Hypoxia and
oxidative stress in breast cancer. Oxidative stress: Its effects on
the growth, metastatic potential and response to therapy of breast
cancer. Breast Cancer Res. 3:323–327. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
28
|
Sharma A, Rajappa M, Satyam A and Sharma
M: Oxidant/anti-oxidant dynamics in patients with advanced cervical
cancer: Correlation with treatment response. Mol Cell Biochem.
341:65–72. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Oliveira CP, Kassab P, Lopasso FP, Souza
HP, Janiszewski M, Laurindo FR, Iriya K and Laudanna AA: Protective
effect of ascorbic acid in experimental gastric cancer: Reduction
of oxidative stress. World J Gastroenterol. 9:446–448. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Calvisi DF, Ladu S, Hironaka K, Factor VM
and Thorgeirsson SS: Vitamin E down-modulates iNOS and NADPH
oxidase in c-Myc/TGF-alpha transgenic mouse model of liver cancer.
J Hepatol. 41:815–822. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Azad N, Rojanasakul Y and Vallyathan V:
Inflammation and lung cancer: Roles of reactive oxygen/nitrogen
species. J Toxicol Environ Health B Crit Rev. 11:1–15. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Fruehauf JP and Trapp V: Reactive oxygen
species: An Achilles' heel of melanoma? Expert Rev Anticancer Ther.
8:1751–1757. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Kuku I, Aydogdu I, Bayraktar N, Kaya E,
Akyol O and Erkurt MA: Oxidant/antioxidant parameters and their
relationship with medical treatment in multiple myeloma. Cell
Biochem Funct. 23:47–50. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Sumi D, Shinkai Y and Kumagai Y: Signal
transduction pathways and transcription factors triggered by
arsenic trioxide in leukemia cells. Toxicol Appl Pharmacol.
244:385–392. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
van de Wetering CI, Coleman MC, Spitz DR,
Smith BJ and Knudson CM: Manganese superoxide dismutase gene dosage
affects chromosomal instability and tumor onset in a mouse model of
T cell lymphoma. Free Radic Biol Med. 44:1677–1686. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Bahar G, Feinmesser R, Shpitzer T,
Popovtzer A and Nagler RM: Salivary analysis in oral cancer
patients: DNA and protein oxidation, reactive nitrogen species, and
antioxidant profile. Cancer. 109:54–59. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Chan DW, Liu VW, Tsao GS, Yao KM, Furukawa
T, Chan KK and Ngan HY: Loss of MKP3 mediated by oxidative stress
enhances tumorigenicity and chemoresistance of ovarian cancer
cells. Carcinogenesis. 29:1742–1750. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Wang M, Topalovski M, Toombs JE, Wright
CM, Moore ZR, Boothman DA, Yanagisawa H, Wang H, Witkiewicz A,
Castrillon DH and Brekken RA: Fibulin-5 blocks microenvironmental
ROS in pancreatic cancer. Cancer Res. 75:5058–5069. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Shan W, Zhong W, Swanlund J and Oberley
TD: Oxidative stress in prostate cancer. Oxidative Stress Cancer
Biol Ther. 301–331. 2011.
|
|
40
|
Ma Q, Cavallin LE, Yan B, Zhu S, Duran EM,
Wang H, Hale LP, Dong C, Cesarman E, Mesri EA and
Goldschmidt-Clermont PJ: Antitumorigenesis of antioxidants in a
transgenic Rac1 model of Kaposi's sarcoma. Proc Natl Acad Sci USA.
106:8683–8688. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Wang J and Yi J: Cancer cell killing via
ROS: To increase or decrease, that is the question. Cancer Biol
Ther. 7:1875–1884. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Klaunig JE, Xu Y, Isenberg JS, Bachowski
S, Kolaja KL, Jiang J, Stevenson DE and Walborg EF Jr: The role of
oxidative stress in chemical carcinogenesis. Environ Health
Perspect. 106 Suppl 1:S289–S295. 1998. View Article : Google Scholar
|
|
43
|
Jabs T: Reactive oxygen intermediates as
mediators of programmed cell death in plants and animals. Biochem
Pharmacol. 57:231–245. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Roos WP, Thomas AD and Kaina B: DNA damage
and the balance between survival and death in cancer biology. Nat
Rev Cancer. 16:20–33. 2016. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Hayashida K, Sano M, Ohsawa I, Shinmura K,
Tamaki K, Kimura K, Endo J, Katayama T, Kawamura A, Kohsaka S, et
al: Inhalation of hydrogen gas reduces infarct size in the rat
model of myocardial ischemia-reperfusion injury. Biochem Biophys
Res Commun. 373:30–35. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Buchholz BM, Kaczorowski DJ, Sugimoto R,
Yang R, Wang Y, Billiar TR, McCurry KR, Bauer AJ and Nakao A:
Hydrogen inhalation ameliorates oxidative stress in transplantation
induced intestinal graft injury. Am J Transplant. 8:2015–2024.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Shirahata S, Hamasaki T, Haramaki K,
Nakamura T, Abe M, Yan H, Kinjo T, Nakamichi N, Kabayama S and
Teruya K: Anti-diabetes effect of water containing hydrogen
molecule and Pt nanoparticles. BMC Proc. 5 Suppl 8:P182011.
View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Saitoh Y, Okayasu H, Xiao L, Harata Y and
Miwa N: Neutral pH hydrogen-enriched electrolyzed water achieves
tumor-preferential clonal growth inhibition over normal cells and
tumor invasion inhibition concurrently with intracellular oxidant
repression. Oncol Res. 17:247–255. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
49
|
Asada R, Kageyama K, Tanaka H, Matsui H,
Kimura M, Saitoh Y and Miwa N: Antitumor effects of nano-bubble
hydrogen-dissolved water are enhanced by coexistent platinum
colloid and the combined hyperthermia with apoptosis-like cell
death. Oncol Rep. 24:1463–1470. 2010.PubMed/NCBI
|
|
50
|
Ren A, Liu R, Miao ZG, Zhang X, Cao PF,
Chen TX, Li CY, Shi L, Jiang AL and Zhao MW: Hydrogen-rich water
regulates effects of ROS balance on morphology, growth and
secondary metabolism via glutathione peroxidase in Ganoderma
lucidum. Environ Microbiol. 19:566–583. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Zhang B, Zhao Z, Meng X, Chen H, Fu G and
Xie K: Hydrogen ameliorates oxidative stress via PI3K-Akt signaling
pathway in UVB-induced HaCaT cells. Int J Mol Med. 41:3653–3661.
2018.PubMed/NCBI
|
|
52
|
Varga V, Németh J, Oláh O, Tóth-Szűki V,
Kovács V, Remzső G and Domoki F: Molecular hydrogen alleviates
asphyxia-induced neuronal cyclooxygenase-2 expression in newborn
pigs. Acta Pharmacol Sin. 22–Mar;2018.(Epub ahead of print).
View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Sun H, Chen L, Zhou W, Hu L, Li L, Tu Q,
Chang Y, Liu Q, Sun X, Wu M and Wang H: The protective role of
hydrogen-rich saline in experimental liver injury in mice. J
Hepatol. 54:471–480. 2011. View Article : Google Scholar : PubMed/NCBI
|
|
54
|
Hattori Y, Kotani T, Tsuda H, Mano Y, Tu
L, Li H, Hirako S, Ushida T, Imai K, Nakano T, et al: Maternal
molecular hydrogen treatment attenuates lipopolysaccharide-induced
rat fetal lung injury. Free Radic Res. 49:1026–1037. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Zhang N, Deng C, Zhang X, Zhang J and Bai
C: Inhalation of hydrogen gas attenuates airway inflammation and
oxidative stress in allergic asthmatic mice. Asthma Res Pract.
4:32018. View Article : Google Scholar : PubMed/NCBI
|
|
56
|
Fukuda K, Asoh S, Ishikawa M, Yamamoto Y,
Ohsawa I and Ohta S: Inhalation of hydrogen gas suppresses hepatic
injury caused by ischemia/reperfusion through reducing oxidative
stress. Biochem Biophys Res Commun. 361:670–674. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
57
|
Xie K, Yu Y, Pei Y, Hou L, Chen S, Xiong L
and Wang G: Protective effects of hydrogen gas on murine
polymicrobial sepsis via reducing oxidative stress and HMGB1
release. Shock. 34:90–97. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
58
|
Ohsawa I, Nishimaki K, Yamagata K,
Ishikawa M and Ohta S: Consumption of hydrogen water prevents
atherosclerosis in apolipoprotein E knockout mice. Biochem Biophys
Res Commun. 377:1195–1198. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
59
|
Gu Y, Huang CS, Inoue T, Yamashita T,
Ishida T, Kang KM and Nakao A: Drinking hydrogen water ameliorated
cognitive impairment in senescence-accelerated mice. J Clin Biochem
Nutr. 46:269–276. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
60
|
Fujita K, Seike T, Yutsudo N, Ohno M,
Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, et
al: Hydrogen in drinking water reduces dopaminergic neuronal loss
in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of
Parkinson's disease. PLoS One. 4:e72472009. View Article : Google Scholar : PubMed/NCBI
|
|
61
|
Kitamura A, Kobayashi S, Matsushita T,
Fujinawa H and Murase K: Experimental verification of protective
effect of hydrogen-rich water against cisplatin-induced
nephrotoxicity in rats using dynamic contrast-enhanced CT. Br J
Radiol. 83:509–514. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
62
|
Zhao W and Robbins ME: Inflammation and
chronic oxidative stress in radiation-induced late normal tissue
injury: Therapeutic implications. Curr Med Chem. 16:130–143. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
63
|
Kang KM, Kang YN, Choi IB, Gu Y, Kawamura
T, Toyoda Y and Nakao A: Effects of drinking hydrogen-rich water on
the quality of life of patients treated with radiotherapy for liver
tumors. Med Gas Res. 1:112011. View Article : Google Scholar : PubMed/NCBI
|
