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Article

Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis

  • Authors:
    • Yupeng Zou
    • Li Li
  • View Affiliations / Copyright

    Affiliations: Department of Gynecologic Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China
  • Pages: 3231-3240
    |
    Published online on: June 26, 2018
       https://doi.org/10.3892/ol.2018.9027
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Abstract

The early detection of ovarian cancer is critical for improving the prognosis of patients, but there are currently insufficient tumor biomarkers for early detection owing to their low diagnostic sensitivity and specificity. The aim of the present study was to investigate the use of the serum antigens C‑C motif chemokine ligand 18 and C‑X‑C motif chemokine ligand 1, and autoantibodies C1D, transmembrane 4 L six family member 1, zinc finger protein 675 and fragile X mental retardation 1 autosomal homolog 1, for the early screening of epithelial ovarian cancer (EOC). The expression of these sex genes/proteins in ovarian cancer and normal ovarian tissue was examined, and the potential functions of the six genes/proteins in ovarian cancer were analyzed by bioinformatics. Finally, these data were verified in clinical samples, and the multi‑analyte suspension array method was compared with the ELISA method. Taken together, these data indicated that these six genes/proteins may serve as potential biomarkers for the early detection of EOC.
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Copy and paste a formatted citation
Spandidos Publications style
Zou Y and Li L: Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis. Oncol Lett 16: 3231-3240, 2018.
APA
Zou, Y., & Li, L. (2018). Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis. Oncology Letters, 16, 3231-3240. https://doi.org/10.3892/ol.2018.9027
MLA
Zou, Y., Li, L."Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis". Oncology Letters 16.3 (2018): 3231-3240.
Chicago
Zou, Y., Li, L."Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis". Oncology Letters 16, no. 3 (2018): 3231-3240. https://doi.org/10.3892/ol.2018.9027
Copy and paste a formatted citation
x
Spandidos Publications style
Zou Y and Li L: Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis. Oncol Lett 16: 3231-3240, 2018.
APA
Zou, Y., & Li, L. (2018). Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis. Oncology Letters, 16, 3231-3240. https://doi.org/10.3892/ol.2018.9027
MLA
Zou, Y., Li, L."Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis". Oncology Letters 16.3 (2018): 3231-3240.
Chicago
Zou, Y., Li, L."Identification of six serum antigens and autoantibodies for the detection of early stage epithelial ovarian carcinoma by bioinformatics analysis and liquid chip analysis". Oncology Letters 16, no. 3 (2018): 3231-3240. https://doi.org/10.3892/ol.2018.9027
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