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Article

MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88

  • Authors:
    • Fan Zhang
    • Yanjie Zhu
    • Guoxin Fan
    • Shuo Hu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China
  • Pages: 3359-3364
    |
    Published online on: June 27, 2018
       https://doi.org/10.3892/ol.2018.9029
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Abstract

Osteosarcoma is the most common primary bone malignancy in children and young adults. It is associated with dysregulation of certain microRNAs (miRNAs/miRs), which provides a target for osteosarcoma therapy. miR‑2682‑3p expression in osteosarcoma cell lines and tissues was assayed by reverse transcription‑quantitative polymerase chain reaction and was upregulated or downregulated by transfection with miRNA mimics or inhibitors. miR‑2682‑3p was downregulated in osteosarcoma tissues and cell lines, and overexpression of miR‑2682‑3p inhibited tumor growth. Further studies revealed that cyclin D1 (CCND)2, matrix metalloproteinase (MMP)8, and myeloid differentiation primary response (Myd)88 were the direct targets of miR‑2682‑3p in osteosarcoma cells. Overexpression of miR‑2682‑3p promoted osteosarcoma cell apoptosis by targeting CCND2, MMP8, and Myd88, and vice‑versa. Therefore, miR‑2682‑3p may act as a tumor suppressor gene, the downregulation of which contributed to the progression and metastasis of osteosarcoma, to provide a potential therapy target for patients with osteosarcoma.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Zhu Y, Fan G and Hu S: MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88. Oncol Lett 16: 3359-3364, 2018.
APA
Zhang, F., Zhu, Y., Fan, G., & Hu, S. (2018). MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88. Oncology Letters, 16, 3359-3364. https://doi.org/10.3892/ol.2018.9029
MLA
Zhang, F., Zhu, Y., Fan, G., Hu, S."MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88". Oncology Letters 16.3 (2018): 3359-3364.
Chicago
Zhang, F., Zhu, Y., Fan, G., Hu, S."MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88". Oncology Letters 16, no. 3 (2018): 3359-3364. https://doi.org/10.3892/ol.2018.9029
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Zhu Y, Fan G and Hu S: MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88. Oncol Lett 16: 3359-3364, 2018.
APA
Zhang, F., Zhu, Y., Fan, G., & Hu, S. (2018). MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88. Oncology Letters, 16, 3359-3364. https://doi.org/10.3892/ol.2018.9029
MLA
Zhang, F., Zhu, Y., Fan, G., Hu, S."MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88". Oncology Letters 16.3 (2018): 3359-3364.
Chicago
Zhang, F., Zhu, Y., Fan, G., Hu, S."MicroRNA‑2682‑3p inhibits osteosarcoma cell proliferation by targeting CCND2, MMP8 and Myd88". Oncology Letters 16, no. 3 (2018): 3359-3364. https://doi.org/10.3892/ol.2018.9029
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