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Article Open Access

Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer

  • Authors:
    • Hong Liao
    • Hongmei Zhu
    • Shanling Liu
    • He Wang
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3465-3472
    |
    Published online on: July 2, 2018
       https://doi.org/10.3892/ol.2018.9059
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Abstract

V‑domain immunoglobulin suppressor of T cell activation (VISTA) is a novel negative immune checkpoint that belongs to the B7 family. VISTA is primarily expressed on hematopoietic cells and inhibits T cell proliferation and cytokine production. The blockade of VISTA has demonstrated promising results in certain murine tumor models. In the present study, an immunohistochemical analysis of VISTA expression on tumor cells, intratumoral immune cells and vascular endothelial cells was performed in a cohort of 65 patients with ovarian cancer (OC). The associations between VISTA expression and different clinicopathological characteristics were evaluated using Fisher's exact test, and the analysis of overall survival in different groups was performed by the construction of Kaplan‑Meier curves. The results indicated that high expression of VISTA on tumor cells or ICs was significantly associated with advanced tumor stage and the presence of lymph node metastasis (LNM). However, the percentage of cases with high expression of VISTA on tumor cells (24.6%) was decreased compared with those with high expression on ICs (44.6%). There was no association between VISTA expression and the 5‑year overall survival rate, and advanced‑stage disease was the only independent predictor of poor prognosis based on multivariate Cox regression analysis. In general, VISTA expression increased with advanced disease stage and LNM, indicating that VISTA expression is involved in the progression of OC. More importantly, these data implicate VISTA as a candidate immunotherapeutic target in OC.
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Copy and paste a formatted citation
Spandidos Publications style
Liao H, Zhu H, Liu S and Wang H: Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer. Oncol Lett 16: 3465-3472, 2018.
APA
Liao, H., Zhu, H., Liu, S., & Wang, H. (2018). Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer. Oncology Letters, 16, 3465-3472. https://doi.org/10.3892/ol.2018.9059
MLA
Liao, H., Zhu, H., Liu, S., Wang, H."Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer". Oncology Letters 16.3 (2018): 3465-3472.
Chicago
Liao, H., Zhu, H., Liu, S., Wang, H."Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer". Oncology Letters 16, no. 3 (2018): 3465-3472. https://doi.org/10.3892/ol.2018.9059
Copy and paste a formatted citation
x
Spandidos Publications style
Liao H, Zhu H, Liu S and Wang H: Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer. Oncol Lett 16: 3465-3472, 2018.
APA
Liao, H., Zhu, H., Liu, S., & Wang, H. (2018). Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer. Oncology Letters, 16, 3465-3472. https://doi.org/10.3892/ol.2018.9059
MLA
Liao, H., Zhu, H., Liu, S., Wang, H."Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer". Oncology Letters 16.3 (2018): 3465-3472.
Chicago
Liao, H., Zhu, H., Liu, S., Wang, H."Expression of V‑domain immunoglobulin suppressor of T cell activation is associated with the advanced stage and presence of lymph node metastasis in ovarian cancer". Oncology Letters 16, no. 3 (2018): 3465-3472. https://doi.org/10.3892/ol.2018.9059
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