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Article Open Access

Identification of genes that predict the biochemical recurrence of prostate cancer

  • Authors:
    • Jianfeng Chu
    • Ning Li
    • Wentao Gai
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Yantaishan Hospital, Yantai, Shandong 264000, P.R. China, Department of Urology, Yantai Municipal Laiyang Central Hospital, Yantai, Shandong 265200, P.R. China
    Copyright: © Chu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3447-3452
    |
    Published online on: July 10, 2018
       https://doi.org/10.3892/ol.2018.9106
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Abstract

Prostate cancer (PCa) is one of the most prevalent cancer types in men. Biochemical recurrence continues to occur in a large proportion of patients after radical prostatectomy. Thus, prognostic biomarkers are required to determine which treatment is suitable. In the present study, RNA‑sequencing gene expression data from The Cancer Genome Atlas was used in order to develop a risk‑score staging system based on the expression of eight genes. Cox multivariate regression was used to predict the outcome of patients with PCa. The biomedical recurrence‑free survival of patients with low‑risk scores was significantly longer compared with patients with high‑risk scores (P=5x10‑7). This result was further validated using another dataset, GSE70769, from the National Center for Biotechnology Information. The prognostic values of other clinical information and risk scores were evaluated for 5‑year biochemical recurrence. The prognostic value of the risk score was determined using an area under curve value of 0.819, predicting the 5‑year biochemical recurrence of patients with PCa. The risk score was identified to be significantly associated with primary tumor stage (P<0.01), Gleason score (P<0.01), and lymph node invasion (P<0.05), but was independent of age. Cox multivariate regression revealed that the risk score was an indicator for prediction of biochemical recurrence. Thus, the risk score is a valuable and robust indicator for predicting the biochemical recurrence of patients with PCa.
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View References

1 

Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ and He J: Cancer statistics in china, 2015. CA Cancer J Clin. 66:115–132. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Brockman JA, Alanee S, Vickers AJ, Scardino PT, Wood DP, Kibel AS, Lin DW, Bianco FJ Jr, Rabah DM, Klein EA, et al: Nomogram predicting prostate cancer-specific mortality for men with biochemical recurrence after radical prostatectomy. Eur Urol. 67:1160–1167. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Torrecilla Lopez J, Hervas A, Zapatero A, Gómez Caamaño A, Macías V, Herruzo I, Maldonado X, Iturriaga Gómez A, Casas F and Segundo González San C: Uroncor consensus statement: Management of biochemical recurrence after radical radiotherapy for prostate cancer: From biochemical failure to castration resistance. Rep Pract Oncol Radiother. 20:259–272. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Algarra R, Hevia M, Tienza A, Merino I, Velis JM, Zudaire J, Robles JE and Pascual I: Survival analysis of patients with biochemical relapse after radical prostatectomy treated with androgen deprivation: Castration-resistance influential factors. Can Urol Assoc J. 8:E333–E341. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Epstein JI, Zelefsky MJ, Sjoberg DD, Nelson JB, Egevad L, Magi-Galluzzi C, Vickers AJ, Parwani AV, Reuter VE, Fine SW, et al: A contemporary prostate cancer grading system: A validated alternative to the gleason score. Eur Urol. 69:428–435. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Huang TB, Dong CP, Zhou GC, Lu SM, Luan Y, Gu X, Liu L and Ding XF: A potential panel of four-long noncoding RNA signature in prostate cancer predicts biochemical recurrence-free survival and disease-free survival. Int Urol Nephrol. 49:825–835. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Zhang H, Cheng S, Wang A, Ma H, Yao B, Qi C, Liu R, Qi S and Xu Y: Expression of RABEX-5 and its clinical significance in prostate cancer. J Exp Clin Cancer Res. 33:312014. View Article : Google Scholar : PubMed/NCBI

8 

Chiang YT, Wang K, Fazli L, Qi RZ, Gleave ME, Collins CC, Gout PW and Wang Y: GATA2 as a potential metastasis-driving gene in prostate cancer. Oncotarget. 5:451–461. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Zhang L, Guo F, Gao X and Wu Y: Golgi phosphoprotein 3 expression predicts poor prognosis in patients with prostate cancer undergoing radical prostatectomy. Mol Med Rep. 12:1298–1304. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Amaro A, Esposito AI, Gallina A, Nees M, Angelini G, Albini A and Pfeffer U: Validation of proposed prostate cancer biomarkers with gene expression data: A long road to travel. Cancer Metastasis Rev. 33:657–671. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Samra Bou E, Klein B, Commes T and Moreaux J: Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients. Oncotarget. 3:824–832. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Ito H, Mo Q, Qin LX, Viale A, Maithel SK, Maker AV, Shia J, Kingham P, Allen P, DeMatteo RP, et al: Gene expression profiles accurately predict outcome following liver resection in patients with metastatic colorectal cancer. PloS One. 8:e816802013. View Article : Google Scholar : PubMed/NCBI

13 

Chang W, Gao X, Han Y, Du Y, Liu Q, Wang L, Tan X, Zhang Q, Liu Y, Zhu Y, et al: Gene expression profiling-derived immunohistochemistry signature with high prognostic value in colorectal carcinoma. Gut. 63:1457–1467. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Salazar R, Roepman P, Capella G, Moreno V, Simon I, Dreezen C, Lopez-Doriga A, Santos C, Marijnen C, Westerga J, et al: Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol. 29:17–24. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Samra Bou E, Klein B, Commes T and Moreaux J: Identification of a 20-gene expression-based risk score as a predictor of clinical outcome in chronic lymphocytic leukemia patients. Biomed Res Int. 2014:4231742014.PubMed/NCBI

16 

Kim SK, Kim SY, Kim JH, Roh SA, Cho DH, Kim YS and Kim JC: A nineteen gene-based risk score classifier predicts prognosis of colorectal cancer patients. Mol Oncol. 8:1653–1666. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Zhang ZL, Zhao LJ, Chai L, Zhou SH, Wang F, Wei Y, Xu YP and Zhao P: Seven LncRNA-mRNA based risk score predicts the survival of head and neck squamous cell carcinoma. Sci Rep. 7:3092017. View Article : Google Scholar : PubMed/NCBI

18 

Ross-Adams H, Lamb AD, Dunning MJ, Halim S, Lindberg J, Massie CM, Egevad LA, Russell R, Ramos-Montoya A, Vowler SL, et al: Integration of copy number and transcriptomics provides risk stratification in prostate cancer: A discovery and validation cohort study. EBioMedicine. 2:1133–1144. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Kim KH, Yang SS, Yoon YS, Lim SB, Yu CS and Kim JC: Validation of the seventh edition of the american joint committee on cancer tumor-node-metastasis (AJCC TNM) staging in patients with stage II and stage III colorectal carcinoma: Analysis of 2511 cases from a medical centre in korea. Colorectal Dis. 13:e220–e226. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Edgar R, Domrachev M and Lash AE: Gene expression omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res. 30:207–210. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Katz S, Irizarry RA, Lin X, Tripputi M and Porter MW: A summarization approach for affymetrix genechip data using a reference training set from a large, biologically diverse database. BMC Bioinformatics. 7:4642006. View Article : Google Scholar : PubMed/NCBI

22 

Ishwaran H and Kogalur UB: Consistency of random survival forests. Stat Probab Lett. 80:1056–1064. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Ishwaran H, Gerds TA, Kogalur UB, Moore RD, Gange SJ and Lau BM: Random survival forests for competing risks. Biostatistics. 15:757–773. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Gautier L, Cope L, Bolstad BM and Irizarry RA: affy-analysis of affymetrix genechip data at the probe level. Bioinformatics. 20:307–315. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Liu Z and Pounds S: An R package that automatically collects and archives details for reproducible computing. BMC Bioinformatics. 15:1382014. View Article : Google Scholar : PubMed/NCBI

26 

Charlop-Powers Z and Brady SF: Phylogeo: An R package for geographic analysis and visualization of microbiome data. Bioinformatics. 31:2909–2911. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Robin X, Turck N, Hainard A, Tiberti N, Lisacek F, Sanchez JC and Müller M: pROC: An open-source package for R and S+ to analyze and compare ROC curves. BMC Bioinformatics. 12:772011. View Article : Google Scholar : PubMed/NCBI

28 

Kim R: Anesthetic technique and cancer recurrence in oncologic surgery: Unraveling the puzzle. Cancer Metastasis Rev. 36:159–177. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Chen J, Miao Z, Xue B, Shan Y, Weng G and Shen B: Long non-coding RNAs in urologic malignancies: Functional roles and clinical translation. J Cancer. 7:1842–1855. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Nimse SB, Sonawane MD, Son KS and Kim T: Biomarker detection technologies and future directions. Analyst. 141:740–755. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Tian X, Zhu X, Yan T, Yu C, Shen C, Hong J, Chen H and Fang JY: Differentially expressed lncrnas in gastric cancer patients: A potential biomarker for gastric cancer prognosis. J Cancer. 8:2575–2586. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Bensalah K, Lotan Y, Karam JA and Shariat SF: New circulating biomarkers for prostate cancer. Prostate Cancer Prostatic Dis. 11:112–120. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Gupta D and Lis CG: Pretreatment serum albumin as a predictor of cancer survival: A systematic review of the epidemiological literature. Nutr J. 9:692010. View Article : Google Scholar : PubMed/NCBI

34 

Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, et al: Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Net Commun. 7:116122016. View Article : Google Scholar

35 

Tang H, Wu Y, Qin Y, Wang H, Jia Y, Yang S, Luo S and Wang Q: Predictive significance of HMGCS2 for prognosis in resected Chinese esophageal squamous cell carcinoma patients. OncoTargets Ther. 10:2553–2560. 2017. View Article : Google Scholar

36 

Saraon P, Cretu D, Musrap N, Karagiannis GS, Batruch I, Drabovich AP, van der Kwast T, Mizokami A, Morrissey C, Jarvi K and Diamandis EP: Quantitative proteomics reveals that enzymes of the ketogenic pathway are associated with prostate cancer progression. Mol Cell Proteomics. 12:1589–1601. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Su SG, Yang M, Zhang MF, Peng QZ, Li MY, Liu LP and Bao SY: miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma. Int J Biochem Cell Biol. 91:53–59. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Sun LN, Zhi Z, Chen LY, Zhou Q, Li XM, Gan WJ, Chen S, Yang M, Liu Y, Shen T, et al: SIRT1 suppresses colorectal cancer metastasis by transcriptional repression of miR-15b-5p. Cancer Lett. 409:104–115. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Edqvist PH, Huvila J, Forsstrom B, Talve L, Carpén O, Salvesen HB, Krakstad C, Grénman S, Johannesson H, Ljungqvist O, et al: Loss of ASRGL1 expression is an independent biomarker for disease-specific survival in endometrioid endometrial carcinoma. Gynecol Oncol. 137:529–537. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chu J, Li N and Gai W: Identification of genes that predict the biochemical recurrence of prostate cancer. Oncol Lett 16: 3447-3452, 2018.
APA
Chu, J., Li, N., & Gai, W. (2018). Identification of genes that predict the biochemical recurrence of prostate cancer. Oncology Letters, 16, 3447-3452. https://doi.org/10.3892/ol.2018.9106
MLA
Chu, J., Li, N., Gai, W."Identification of genes that predict the biochemical recurrence of prostate cancer". Oncology Letters 16.3 (2018): 3447-3452.
Chicago
Chu, J., Li, N., Gai, W."Identification of genes that predict the biochemical recurrence of prostate cancer". Oncology Letters 16, no. 3 (2018): 3447-3452. https://doi.org/10.3892/ol.2018.9106
Copy and paste a formatted citation
x
Spandidos Publications style
Chu J, Li N and Gai W: Identification of genes that predict the biochemical recurrence of prostate cancer. Oncol Lett 16: 3447-3452, 2018.
APA
Chu, J., Li, N., & Gai, W. (2018). Identification of genes that predict the biochemical recurrence of prostate cancer. Oncology Letters, 16, 3447-3452. https://doi.org/10.3892/ol.2018.9106
MLA
Chu, J., Li, N., Gai, W."Identification of genes that predict the biochemical recurrence of prostate cancer". Oncology Letters 16.3 (2018): 3447-3452.
Chicago
Chu, J., Li, N., Gai, W."Identification of genes that predict the biochemical recurrence of prostate cancer". Oncology Letters 16, no. 3 (2018): 3447-3452. https://doi.org/10.3892/ol.2018.9106
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