Open Access

Identification of genes that predict the biochemical recurrence of prostate cancer

  • Authors:
    • Jianfeng Chu
    • Ning Li
    • Wentao Gai
  • View Affiliations

  • Published online on: July 10, 2018     https://doi.org/10.3892/ol.2018.9106
  • Pages: 3447-3452
  • Copyright: © Chu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Prostate cancer (PCa) is one of the most prevalent cancer types in men. Biochemical recurrence continues to occur in a large proportion of patients after radical prostatectomy. Thus, prognostic biomarkers are required to determine which treatment is suitable. In the present study, RNA‑sequencing gene expression data from The Cancer Genome Atlas was used in order to develop a risk‑score staging system based on the expression of eight genes. Cox multivariate regression was used to predict the outcome of patients with PCa. The biomedical recurrence‑free survival of patients with low‑risk scores was significantly longer compared with patients with high‑risk scores (P=5x10‑7). This result was further validated using another dataset, GSE70769, from the National Center for Biotechnology Information. The prognostic values of other clinical information and risk scores were evaluated for 5‑year biochemical recurrence. The prognostic value of the risk score was determined using an area under curve value of 0.819, predicting the 5‑year biochemical recurrence of patients with PCa. The risk score was identified to be significantly associated with primary tumor stage (P<0.01), Gleason score (P<0.01), and lymph node invasion (P<0.05), but was independent of age. Cox multivariate regression revealed that the risk score was an indicator for prediction of biochemical recurrence. Thus, the risk score is a valuable and robust indicator for predicting the biochemical recurrence of patients with PCa.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Chu J, Li N and Gai W: Identification of genes that predict the biochemical recurrence of prostate cancer. Oncol Lett 16: 3447-3452, 2018
APA
Chu, J., Li, N., & Gai, W. (2018). Identification of genes that predict the biochemical recurrence of prostate cancer. Oncology Letters, 16, 3447-3452. https://doi.org/10.3892/ol.2018.9106
MLA
Chu, J., Li, N., Gai, W."Identification of genes that predict the biochemical recurrence of prostate cancer". Oncology Letters 16.3 (2018): 3447-3452.
Chicago
Chu, J., Li, N., Gai, W."Identification of genes that predict the biochemical recurrence of prostate cancer". Oncology Letters 16, no. 3 (2018): 3447-3452. https://doi.org/10.3892/ol.2018.9106