Low‑grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A case report

Mikami,Yurie; Fujii,Shinsuke; Kohashi,Ken‑Ichi; Yamada,Yuichi; Moriyama,Masafumi; Kawano,Shintaro; Nakamura,Seiji; Oda,Yoshinao; Kiyoshima,Tamotsu

doi:10.3892/ol.2018.9115

Low‑grade myofibroblastic sarcoma arising in the tip of the tongue with intravascular invasion: A case report

Authors:
- Yurie Mikami
- Shinsuke Fujii
- Ken‑Ichi Kohashi
- Yuichi Yamada
- Masafumi Moriyama
- Shintaro Kawano
- Seiji Nakamura
- Yoshinao Oda
- Tamotsu Kiyoshima
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Affiliations: Laboratory of Oral Pathology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan, Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan, Section of Maxillofacial Oncology, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi‑ku, Fukuoka 812‑8582, Japan
Published online on: July 10, 2018 https://doi.org/10.3892/ol.2018.9115
Pages: 3889-3894

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Abstract

Low‑grade myofibroblastic sarcoma (LGMS) is a rare intermediate tumor, which rarely metastasizes and has myofibroblastic differentiation in various sites. It is particularly associated with the tongue in the head and neck region. The lack of any pathological features means it is difficult to make a conclusive diagnosis of LGMS. The immunohistochemical features and genomic rearrangements, including SS18‑SSXs and MYH9‑USP6s and the genetic mutations of cancer‑associated genes, including APC, CTNNB1, EGFR, KRAS, PIK3CA and p53 were examined in a case of LGMS arising in the tip of the tongue. Immunohistochemically, the tumor cells were positive for alpha‑smooth muscle actin and vimentin, as in previous reports. They demonstrated neither genomic rearrangements nor point mutations of cancer‑associated genes. Although several tumor cells demonstrated intravascular invasion, the MIB‑l labeling index of the cells was the same as the original lesion. To the best of our knowledge, this is the first case report of LGMS arising in the tip of the tongue with intravascular invasion.

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