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Review

Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review)

  • Authors:
    • Armando De Virgilio
    • Massimo Ralli
    • Lucia Longo
    • Patrizia Mancini
    • Giuseppe Attanasio
    • Francesca Atturo
    • Marco De Vincentiis
    • Antonio Greco
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Humanitas Clinical and Research Center, I‑20089 Milan, Italy, Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, I‑00186 Rome, Italy, Department of Sense Organs, Sapienza University of Rome, I‑00186 Rome, Italy
  • Pages: 3415-3423
    |
    Published online on: July 12, 2018
       https://doi.org/10.3892/ol.2018.9140
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Abstract

Patients affected by aggressive neoplasms with a high propensity to metastasize to the skin, including some types of head and neck cancer, may benefit from electrochemotherapy, a modality that combines the electroporation of cell membranes and chemotherapy to facilitate the transport of non‑permeant molecules into cells; the host immune response consequently participates in achieving the abolition of tumors. Electrochemotherapy can be successfully used for skin metastases of head and neck tumors and, with some limitations, for primary and relapsing neoplasms; it can also be applied on an outpatient basis with a favorable cost‑benefit ratio and it is a repeatable treatment that, if necessary, can be followed by traditional antineoplastic therapies. Although still a palliative treatment, the good level of tolerability and the high success rates of electrochemotherapy make it worth consideration among treatment options in selected patients.
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Copy and paste a formatted citation
Spandidos Publications style
De Virgilio A, Ralli M, Longo L, Mancini P, Attanasio G, Atturo F, De Vincentiis M and Greco A: Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review). Oncol Lett 16: 3415-3423, 2018.
APA
De Virgilio, A., Ralli, M., Longo, L., Mancini, P., Attanasio, G., Atturo, F. ... Greco, A. (2018). Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review). Oncology Letters, 16, 3415-3423. https://doi.org/10.3892/ol.2018.9140
MLA
De Virgilio, A., Ralli, M., Longo, L., Mancini, P., Attanasio, G., Atturo, F., De Vincentiis, M., Greco, A."Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review)". Oncology Letters 16.3 (2018): 3415-3423.
Chicago
De Virgilio, A., Ralli, M., Longo, L., Mancini, P., Attanasio, G., Atturo, F., De Vincentiis, M., Greco, A."Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review)". Oncology Letters 16, no. 3 (2018): 3415-3423. https://doi.org/10.3892/ol.2018.9140
Copy and paste a formatted citation
x
Spandidos Publications style
De Virgilio A, Ralli M, Longo L, Mancini P, Attanasio G, Atturo F, De Vincentiis M and Greco A: Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review). Oncol Lett 16: 3415-3423, 2018.
APA
De Virgilio, A., Ralli, M., Longo, L., Mancini, P., Attanasio, G., Atturo, F. ... Greco, A. (2018). Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review). Oncology Letters, 16, 3415-3423. https://doi.org/10.3892/ol.2018.9140
MLA
De Virgilio, A., Ralli, M., Longo, L., Mancini, P., Attanasio, G., Atturo, F., De Vincentiis, M., Greco, A."Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review)". Oncology Letters 16.3 (2018): 3415-3423.
Chicago
De Virgilio, A., Ralli, M., Longo, L., Mancini, P., Attanasio, G., Atturo, F., De Vincentiis, M., Greco, A."Electrochemotherapy in head and neck cancer: A review of an emerging cancer treatment (Review)". Oncology Letters 16, no. 3 (2018): 3415-3423. https://doi.org/10.3892/ol.2018.9140
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