Role of YAP in lung cancer resistance to cisplatin

  • Authors:
    • Juan Song
    • Li‑Xia Xie
    • Xin‑Yi Zhang
    • Ping Hu
    • Mei‑Fang Long
    • Fang Xiong
    • Juan Huang
    • Xiao‑Qun Ye
  • View Affiliations

  • Published online on: July 12, 2018     https://doi.org/10.3892/ol.2018.9141
  • Pages: 3949-3954
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Abstract

Yes‑associated protein (YAP) serves a critical role in the initiation and progression of a variety of types of cancer via modulating the expression of genes involved in cell proliferation and the downregulation of apoptosis. Recent studies have suggested that YAP is responsible for the development of drug resistance and cancer metastasis and recurrence. However, the association between YAP and chemoresistance in lung cancer, particularly in lung cancer stem cells (LCSCs) remains largely unknown. In the current study, lung cancer cell spheres were established using the A549 cell line, which demonstrated stem cell properties. It was revealed that YAP was overexpressed in lung cancer spheres compared with normal A549 adherent cells and was associated with enhanced cisplatin (CDDP) resistance. Knockdown of YAP effectively sensitized the adherent A549 and tumor spheres to CDDP treatment and resulted in enhanced cell death. These results suggest that YAP serves a critical role in LCSCs drug resistance and YAP targeting could become a promising adjuvant to current the chemotherapy for lung cancer.
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September-2018
Volume 16 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Song J, Xie LX, Zhang XY, Hu P, Long MF, Xiong F, Huang J and Ye XQ: Role of YAP in lung cancer resistance to cisplatin. Oncol Lett 16: 3949-3954, 2018
APA
Song, J., Xie, L., Zhang, X., Hu, P., Long, M., Xiong, F. ... Ye, X. (2018). Role of YAP in lung cancer resistance to cisplatin. Oncology Letters, 16, 3949-3954. https://doi.org/10.3892/ol.2018.9141
MLA
Song, J., Xie, L., Zhang, X., Hu, P., Long, M., Xiong, F., Huang, J., Ye, X."Role of YAP in lung cancer resistance to cisplatin". Oncology Letters 16.3 (2018): 3949-3954.
Chicago
Song, J., Xie, L., Zhang, X., Hu, P., Long, M., Xiong, F., Huang, J., Ye, X."Role of YAP in lung cancer resistance to cisplatin". Oncology Letters 16, no. 3 (2018): 3949-3954. https://doi.org/10.3892/ol.2018.9141