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Article

IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma

  • Authors:
    • Peipei Fang
    • Luxia Xiang
    • Shanshan Huang
    • Lingxiang Jin
    • Guangyao Zhou
    • Lu Zhuge
    • Jie Li
    • Hengwei Fan
    • Lingli Zhou
    • Chenwei Pan
    • Yi Zheng
  • View Affiliations / Copyright

    Affiliations: Department of Infectious Disease, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Department of Hepatobiliary Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China, Department of Pathology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China
  • Pages: 4729-4736
    |
    Published online on: July 19, 2018
       https://doi.org/10.3892/ol.2018.9176
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Abstract

Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol‑requiring enzyme 1α (IRE1α)‑X‑box‑binding protein 1 (XBP1) signaling is the most conserved. These pathways are implicated in a variety of types of cancer, including hepatocellular carcinoma (HCC). However, the role of IRE1α‑XBP1 signaling in the development of HCC remains unclear. In the current study, reverse transcription‑quantiative polymerase chain reaction was used to analyze the expression levels of XBP1 and interleukin (IL)‑6 in human tissues and cells. ChIP and luciferase reporter assays were utilized to investigate the interaction between XBP1s and IL‑6 promoter DNA. It was revelaed that IRE1α‑XBP1 signaling promotes the proliferation of HCC cells via regulating hepatic IL‑6 expression. It was observed that the splicing levels of XBP1 and hepatic IL‑6 content were increased and positively correlated with each other in human HCC tissues (r2=0.5846, P=0.004). Ectopic expression of IRE1α or XBP1s increased IL‑6 levels in LO2 and Hep3B cells. In addition, pharmacological inhibition of IRE1α reduced the levels of IL‑6 expression and secretion through blocking the generation of XBP1s, which bound directly to the IL‑6 promoter and activated its expression. Further investigation demonstrated that IL‑6 driven by XBP1s was secreted outside of cells and activated signal transducer and activator of transcription 3 (STAT3) signaling in an autocrine/paracrine manner, to regulate the proliferation of Hep3B cells. Blockage of IL‑6‑STAT3 signaling with tocilizumab attenuated the effect of IRE1α‑XBP1 signaling in promoting Hep3B cell proliferation. In conclusion, the present study revealed that IRE1α‑XBP1 signaling promotes carcinogenesis of HCC by regulating the activation of the IL‑6‑STAT3 signaling pathway.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: Epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Taniguchi K and Karin M: IL-6 and related cytokines as the critical lynchpins between inflammation and cancer. Semin Immunol. 26:54–74. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Nakagawa H, Umemura A, Taniguchi K, Font-Burgada J, Dhar D, Ogata H, Zhong Z, Valasek MA, Seki E, Hidalgo J, et al: ER stress cooperates with hypernutrition to trigger TNF-dependent spontaneous HCC development. Cancer Cell. 26:331–343. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H and Karin M: Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 140:197–208. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G and Karin M: Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 14:156–165. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Trikha M, Corringham R, Klein B and Rossi JF: Targeted anti-interleukin-6 monoclonal antibody therapy for cancer: A review of the rationale and clinical evidence. Clin Cancer Res. 9:4653–4665. 2003.PubMed/NCBI

8 

Tilg H, Wilmer A, Vogel W, Herold M, Nölchen B, Judmaier G and Huber C: Serum levels of cytokines in chronic liver diseases. Gastroenterology. 103:264–274. 1992. View Article : Google Scholar : PubMed/NCBI

9 

Wong VW, Yu J, Cheng AS, Wong GL, Chan HY, Chu ES, Ng EK, Chan FK, Sung JJ and Chan HL: High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int J Cancer. 124:2766–2770. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Nakagawa H, Maeda S, Yoshida H, Tateishi R, Masuzaki R, Ohki T, Hayakawa Y, Kinoshita H, Yamakado M, Kato N, et al: Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: An analysis based on gender differences. Int J Cancer. 125:2264–2269. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Ron D and Walter P: Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol. 8:519–529. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Schröder M and Kaufman RJ: The mammalian unfolded protein response. Annu Rev Biochem. 74:739–789. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Walter P and Ron D: The unfolded protein response: From stress pathway to homeostatic regulation. Science. 334:1081–1086. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Yoshida H, Matsui T, Yamamoto A, Okada T and Mori K: XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell. 107:881–891. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Jiang CC, Yang F, Thorne RF, Zhu BK, Hersey P and Zhang XD: Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt. Neoplasia. 11:436–447. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, et al: Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress. Cell. 158:534–548. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Xue Z, He Y, Ye K, Gu Z, Mao Y and Qi L: A conserved structural determinant located at the interdomain region of mammalian inositol-requiring enzyme 1alpha. J Biol Chem. 286:30859–30866. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Ding BB, Yu JJ, Yu RY, Mendez LM, Shaknovich R, Zhang Y, Cattoretti G and Ye BH: Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas. Blood. 111:1515–1523. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Niu G, Bowman T, Huang M, Shivers S, Reintgen D, Daud A, Chang A, Kraker A, Jove R and Yu H: Roles of activated Src and Stat3 signaling in melanoma tumor cell growth. Oncogene. 21:7001–7010. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Lin L, Liu A, Peng Z, Lin HJ, Li PK, Li C and Lin J: STAT3 is necessary for proliferation and survival in colon cancer-initiating cells. Cancer Res. 71:7226–7237. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Chen C and Zhang X: IRE1α-XBP1 pathway promotes melanoma progression by regulating IL-6/STAT3 signaling. J Transl Med. 15:422017. View Article : Google Scholar : PubMed/NCBI

22 

Martinon F, Chen X, Lee AH and Glimcher LH: TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nat Immunol. 11:411–418. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Argemí J, Kress TR, Chang HCY, Ferrero R, Bértolo C, Moreno H, González-Aparicio M, Uriarte I, Guembe L, Segura V, et al: X-box binding protein 1 regulates unfolded protein, acute-phase, and DNA damage responses during regeneration of mouse liver. Gastroenterology. 152:1203–1216.e15. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, et al: The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat Immunol. 18:519–529. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Kanemoto S, Kondo S, Ogata M, Murakami T, Urano F and Imaizumi K: XBP1 activates the transcription of its target genes via an ACGT core sequence under ER stress. Biochem Biophys Res Commun. 331:1146–1153. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Liu Y, Shao M, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, et al: Role for the endoplasmic reticulum stress sensor IRE1α in liver regenerative responses. J Hepatol. 62:590–598. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Xu T, Yang L, Yan C, Wang X, Huang P, Zhao F, Zhao L, Zhang M, Jia W, Wang X and Liu Y: The IRE1α-XBP1 pathway regulates metabolic stress-induced compensatory proliferation of pancreatic β-cells. Cell Res. 24:1137–1140. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Thorpe JA and Schwarze SR: IRE1αlpha controls cyclin A1 expression and promotes cell proliferation through XBP-1. Cell Stress Chaperones. 15:497–508. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Lin JH, Li H, Yasumura D, Cohen HR, Zhang C, Panning B, Shokat KM, Lavail MM and Walter P: IRE1 signaling affects cell fate during the unfolded protein response. Science. 318:944–949. 2007. View Article : Google Scholar : PubMed/NCBI

30 

Lee AH, Scapa EF, Cohen DE and Glimcher LH: Regulation of hepatic lipogenesis by the transcription factor XBP1. Science. 320:1492–1496. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Shao M, Shan B, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, et al: Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s-PPARα axis signalling. Nat Commun. 5:35282014. View Article : Google Scholar : PubMed/NCBI

32 

Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO and Kaufman RJ: IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metab. 16:473–486. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Deng Y, Wang ZV, Tao C, Gao N, Holland WL, Ferdous A, Repa JJ, Liang G, Ye J, Lehrman MA, et al: The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism. J Clin Invest. 123:455–468. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB and Ozcan U: Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat Med. 17:356–365. 2011. View Article : Google Scholar : PubMed/NCBI

35 

He G and Karin M: NF-κB and STAT3 - key players in liver inflammation and cancer. Cell Res. 21:159–168. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fang P, Xiang L, Huang S, Jin L, Zhou G, Zhuge L, Li J, Fan H, Zhou L, Pan C, Pan C, et al: IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma. Oncol Lett 16: 4729-4736, 2018.
APA
Fang, P., Xiang, L., Huang, S., Jin, L., Zhou, G., Zhuge, L. ... Zheng, Y. (2018). IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma. Oncology Letters, 16, 4729-4736. https://doi.org/10.3892/ol.2018.9176
MLA
Fang, P., Xiang, L., Huang, S., Jin, L., Zhou, G., Zhuge, L., Li, J., Fan, H., Zhou, L., Pan, C., Zheng, Y."IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma". Oncology Letters 16.4 (2018): 4729-4736.
Chicago
Fang, P., Xiang, L., Huang, S., Jin, L., Zhou, G., Zhuge, L., Li, J., Fan, H., Zhou, L., Pan, C., Zheng, Y."IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 4729-4736. https://doi.org/10.3892/ol.2018.9176
Copy and paste a formatted citation
x
Spandidos Publications style
Fang P, Xiang L, Huang S, Jin L, Zhou G, Zhuge L, Li J, Fan H, Zhou L, Pan C, Pan C, et al: IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma. Oncol Lett 16: 4729-4736, 2018.
APA
Fang, P., Xiang, L., Huang, S., Jin, L., Zhou, G., Zhuge, L. ... Zheng, Y. (2018). IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma. Oncology Letters, 16, 4729-4736. https://doi.org/10.3892/ol.2018.9176
MLA
Fang, P., Xiang, L., Huang, S., Jin, L., Zhou, G., Zhuge, L., Li, J., Fan, H., Zhou, L., Pan, C., Zheng, Y."IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma". Oncology Letters 16.4 (2018): 4729-4736.
Chicago
Fang, P., Xiang, L., Huang, S., Jin, L., Zhou, G., Zhuge, L., Li, J., Fan, H., Zhou, L., Pan, C., Zheng, Y."IRE1α‑XBP1 signaling pathway regulates IL‑6 expression and promotes progression of hepatocellular carcinoma". Oncology Letters 16, no. 4 (2018): 4729-4736. https://doi.org/10.3892/ol.2018.9176
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